<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2 20190208//EN" "http://jats.nlm.nih.gov/publishing/1.2/JATS-journalpublishing1.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="research-article" dtd-version="1.2" xml:lang="en">
    <front>
        <journal-meta>
            <journal-id journal-id-type="pmc">Gates Open Res</journal-id>
            <journal-title-group>
                <journal-title>Gates Open Research</journal-title>
            </journal-title-group>
            <issn pub-type="epub">2572-4754</issn>
            <publisher>
                <publisher-name>F1000 Research Limited</publisher-name>
                <publisher-loc>London, UK</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="doi">10.12688/gatesopenres.12902.2</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Research Article</subject>
                </subj-group>
                <subj-group>
                    <subject>Articles</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Knowledge and factors influencing long acting reversible contraceptive use among women of reproductive age in Nigeria</article-title>
                <fn-group content-type="pub-status">
                    <fn>
                        <p>[version 2; peer review: 2 approved with reservations]</p>
                    </fn>
                </fn-group>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author" corresp="yes">
                    <name>
                        <surname>Bolarinwa</surname>
                        <given-names>Obasanjo Afolabi</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-9208-6408</uri>
                    <xref ref-type="corresp" rid="c1">a</xref>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Olagunju</surname>
                        <given-names>Olalekan Seun</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Software</role>
                    <uri content-type="orcid">https://orcid.org/0000-0001-8394-133X</uri>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <aff id="a1">
                    <label>1</label>Department of Demography and Social Statistics, Obafemi Awolowo University, Ile-Ife, Osun State, 1000009, Nigeria</aff>
            </contrib-group>
            <author-notes>
                <corresp id="c1">
                    <label>a</label>
                    <email xlink:href="mailto:bolarinwaobasanjo@hotmail.com">bolarinwaobasanjo@hotmail.com</email>
                </corresp>
                <fn fn-type="conflict">
                    <p>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>23</day>
                <month>4</month>
                <year>2020</year>
            </pub-date>
            <pub-date pub-type="collection">
                <year>2019</year>
            </pub-date>
            <volume>3</volume>
            <elocation-id>7</elocation-id>
            <history>
                <date date-type="accepted">
                    <day>15</day>
                    <month>4</month>
                    <year>2020</year>
                </date>
            </history>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2020 Bolarinwa OA and Olagunju OS</copyright-statement>
                <copyright-year>2020</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <self-uri content-type="pdf" xlink:href="https://gatesopenresearch.org/articles/3-7/pdf"/>
            <abstract>
                <p>
                    <bold>Background:</bold> Approximately 48% of unintended pregnancies occur as a result of contraceptive failure around the world, which is largely due to incorrect use, poor adherence and/or technology failure. Long-acting reversible contraceptive (LARC) methods have been developed to close this gap because it&#x2019;s not dependent on compliance with a pill-taking regimen; remembering to change patch or ring; or fixing an appointment with physicians. The main aim of this study is to identify the factors influencing the women associated with use of LARC and to examine the relationship between knowledge of LARC and its current use.</p>
                <p>
                    <bold>Methods:</bold> This study assessed the PMA2020 methodology and secondary dataset using female datasets from PMA 2016 (Round 3) exercise. PMA 2016 was a survey carried out in seven states of Nigeria. The target population for this study was women of reproductive age (15&#x2013;49 years) currently using contraception prior to the survey. The sample size of women meeting inclusion criteria in this study was 1927. The data were analyzed using frequency distribution, chi-square and logistic regression at 5% level of significant.</p>
                <p>
                    <bold>Results:</bold> The results showed that 21.0% of women were using traditional methods. Concerning LARC methods, the table showed that 14.8% of the sampled women were using LARC methods. Findings further showed that at both levels of analyses there is a significant relationship (P&lt;0.05 and P=0.00 for binary and multivariable logistic regression, respectively) between knowledge of LARCs and uses in this study. This means that knowledge of LARC &amp; other socio-demographic variables among women of reproductive age in Nigeria can influence the use of it.</p>
                <p>
                    <bold>Conclusions:</bold> From the result of the study we concluded that 14.8% of women using contraception were using LARC. Additionally, level of education, age of women, household wealth and number of living children were significantly associated with using LARC.</p>
            </abstract>
            <kwd-group kwd-group-type="author">
                <kwd>Knowledge</kwd>
                <kwd>Factors</kwd>
                <kwd>LARC</kwd>
                <kwd>Contraceptive use</kwd>
                <kwd>Women</kwd>
                <kwd>Reproductive age</kwd>
                <kwd>Influencing</kwd>
                <kwd>Nigeria.</kwd>
            </kwd-group>
            <funding-group>
                <award-group id="fund-1" xlink:href="http://dx.doi.org/10.13039/100000865">
                    <funding-source>Gates Foundation</funding-source>
                    <award-id>OPP1181398</award-id>
                </award-group>
                <funding-statement>This research was sponsored by The Gates Foundation (OPP1181398).</funding-statement>
                <funding-statement>
                    <italic>The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</italic>
                </funding-statement>
            </funding-group>
        </article-meta>
        <notes>
            <sec sec-type="version-changes">
                <label>Revised</label>
                <title>Amendments from Version 1</title>
                <p>Major differences are in text editing, insertion of new table and a new figure.</p>
            </sec>
        </notes>
    </front>
    <body>
        <sec sec-type="intro">
            <title>Introduction</title>
            <p>The rising use of contraception in Nigeria has given women the ability to choose the number and spacing of their children. It has also presented them with various remarkable life-saving benefits, such as reduction in maternal and infant mortality, good child spacing and better postpartum health outcomes. Recently, the expansion in choice of contraceptives available has given women the option of adopting the use of Long-acting reversible contraceptives (LARCs) which are implant and intra-uterine device contraceptive methods that are highly effective and convenient with an added advantage of being long-lasting, require little or no maintenance. It has much better compliance rates than other hormonal methods and is also cost effective. LARCs are ideal pregnancy prevention options for many women compared with shorter-term and user-dependent methods, both of which increase the risk of non-compliance related method failure
                <sup>
                    <xref ref-type="bibr" rid="ref-1">1</xref>&#x2013;
                    <xref ref-type="bibr" rid="ref-4">4</xref>
                </sup>.</p>
            <p>Long-acting devices, when initiated, provide at least 3 years of continuous pregnancy protection for women, and can give up to 10 years of protection. These devices are 99% effective because they are not subject to errors in use, unlike short-acting methods
                <sup>
                    <xref ref-type="bibr" rid="ref-2">2</xref>
                </sup>. Also LARC methods have the ability to reduce the gap between &#x201c;typical use&#x201d; and perfect use&#x201d; failure rates
                <sup>
                    <xref ref-type="bibr" rid="ref-1">1</xref>
                </sup>. Approximately 48% of unintended pregnancies occur as a result of contraceptive failure around the world
                <sup>
                    <xref ref-type="bibr" rid="ref-5">5</xref>
                </sup>, which is largely due to incorrect use, poor adherence and/or technology failure. This can be avoided with the use of LARC methods, because they are not dependent on compliance with a pill-taking regimen, remembering to change a patch or ring, or arranging an appointment with physicians
                <sup>
                    <xref ref-type="bibr" rid="ref-6">6</xref>,
                    <xref ref-type="bibr" rid="ref-7">7</xref>
                </sup>.</p>
            <p>Several studies have established that women in sub-Saharan Africa are often unable to obtain or use modern contraception, particularly the long acting methods, for many reasons associated with both supply and demand side
                <sup>
                    <xref ref-type="bibr" rid="ref-8">8</xref>,
                    <xref ref-type="bibr" rid="ref-9">9</xref>
                </sup>. Nigeria is not particularly exempted with Long Acting Contraceptive Prevalent use of 3.1%
                <sup>
                    <xref ref-type="bibr" rid="ref-10">10</xref>
                </sup>.</p>
            <p>Nigeria&#x2019;s total fertility rate (5.5) is one of the lowest in sub-Saharan Africa and globally. This is due largely to her high unmet need for family planning of (21.8%). Use of contraception is relatively low (17.1%) and this also reflected in the number of women that subscribed to LARC despite being the most cost-effective contraceptives. In Nigeria, knowledge about LARC in terms of intrauterine device (IUD) and implant shows that 36.8% of women have knowledge of IUD and 49.5% of implants
                <sup>
                    <xref ref-type="bibr" rid="ref-11">11</xref>,
                    <xref ref-type="bibr" rid="ref-12">12</xref>
                </sup> which is also low.</p>
            <p>Despite the efficacy and safety of LARC, the use is not widespread among women of reproductive age in Nigeria. Hence, this paper examined the relationship between women&#x2019;s knowledge of LARC and factors influencing the use of LARC among women of reproductive age in Nigeria in order to guide policy makers&#x2019; decisions.</p>
            <p>This research paper sought to identify the relationship between knowledge and factors influencing the use of LARC among women of reproductive age in Nigeria.</p>
        </sec>
        <sec sec-type="intro">
            <title>Methods</title>
            <sec>
                <title>Data source</title>
                <p>The study employed secondary data and methodology from Performance Monitoring and Accountability (PMA) 2016 dataset
                    <sup>
                        <xref ref-type="bibr" rid="ref-12">12</xref>,
                        <xref ref-type="bibr" rid="ref-13">13</xref>
                    </sup>. PMA 2016 was a cross sectional survey carried out in 7 states of Nigeria, Anambra, Kaduna, Kano, Lagos Nasarawa, Rivers and Taraba States between the 4
                    <sup>th</sup> day of May to the 31
                    <sup>st</sup> day of June, 2016. The survey used aboriginal enumerators who were familiar with the enumeration areas and had a good command of the local language. A multistage sampling technique was employed, first to select enumeration areas (EAs) in each local government (LG) of the state, and to randomly select households for an interview in each selected EAs. All females of reproductive age (15&#x2013;49 years) living within the selected household were administered a female questionnaire by the enumerators. Information recorded on the questionnaires included the eligible female&#x2019;s background information, birth history, fertility preference, use of family planning methods and their reproductive health information among others. A total of 11,177 women were interviewed. The questionnaires used are available on OSF
                    <sup>
                        <xref ref-type="bibr" rid="ref-14">14</xref>
                    </sup>.</p>
            </sec>
            <sec>
                <title>Scope of study</title>
                <p>This study was limited to the PMA2020 secondary dataset using female datasets from PMA 2016 (Round 3) exercise
                    <sup>
                        <xref ref-type="bibr" rid="ref-12">12</xref>
                    </sup>. It is expected to provide further insight into factors contributing to use of long acting contraception in Nigeria. The target population for this study was women of reproductive age (15&#x2013;49) who are currently using contraception prior to the survey. Accordingly, for women who met the inclusion criteria, the sample size was 1927.</p>
            </sec>
            <sec>
                <title>Operational definitions and study variables</title>
                <p>In this study, the primary outcome of interest was LARC use among current contraceptive users (This is defined as women of reproductive age (15&#x2013;49 years) that are currently using contraception or whose partner are using at the time of the survey). The study focused specifically on contraceptive users rather than all of those at risk for unintended pregnancy. Current use of a LARC method is defined here as use of the contraceptive implant or the IUD during the month of the interview.</p>
                <p>Knowledge of LARC was assessed by whether respondent have heard of implant or IUD. Respondents were considered as having knowledge if they responded &#x201c;Yes&#x201d; to the question &#x201c;Have you ever heard of implant or IUD&#x201d; at the time of interview. Source of information about family planning was also included in the study.</p>
                <p>In order to assess women&#x2019;s demographic characteristics likely to influence LARC use, selected demographic characteristics that are theoretically related to use of LARC were included in the analyses. These include women&#x2019;s level of education, household wealth index, number of births at first use of contraceptive, place of residence, age and marital status.</p>
                <p>To answer the stated objectives, we first present frequency distribution of all the variables used in the study. Pattern of LARC use was assessed by the proportion of all contraceptive users using LARC methods by selected demographic characteristics. Knowledge of LARC was cross tabulated by use of LARC to show the relationship between the two variables and chi-square test was used to show this relationship. Lastly, binary logistic regression was used to estimate odd ratios adjusting for demographic factors influencing the use of LARC.</p>
            </sec>
            <sec>
                <title>Data processing and analysis</title>
                <p>Data was exported to Stata version 14 for analysis. Descriptive statistics, including frequencies and proportions were used to summarize the variables. Binary logistic regression was used. adjusted odd ratios (AOR) with 95% confidence interval was estimated to show the strengths of associations. Finally, a p-value of less than 0.05 in the multivariable logistic regression analysis was used to identify variables significantly associated with long acting and reversible family planning method utilization.</p>
            </sec>
        </sec>
        <sec sec-type="results">
            <title>Results</title>
            <p>
                <xref ref-type="table" rid="T1">Table 1</xref> shows the distribution of respondents that are currently using of contraception by selected socio-demographic characteristics. A total of 1,927 females were found to be currently using of contraception in the study. The mean age of respondents was 31.3 years and more than 40% of the current users fell within the age range of 25&#x2013;34 years. Concerning the level of education, almost half (49.7%) of females had attended secondary education and whilst 24.1% had higher education. Marital status shows that majority (76.6%) of the respondents were currently married at the time of interview. More than half (59%) of the respondents reside in urban areas while 41% reside in rural areas. Regarding wealth index, the table shows that 43.1% were from rich households, 35.6% from poor household and 21.3% were from middle household. More than half (52.6%) of the respondents had 1&#x2013;4 children before they started using of contraception. Raw data are available on OSF
                <sup>
                    <xref ref-type="bibr" rid="ref-14">14</xref>
                </sup>.</p>
            <table-wrap id="T1" orientation="portrait" position="anchor">
                <label>Table 1. </label>
                <caption>
                    <title>Socio-demographic characteristics of respondents.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="1">Variables</th>
                            <th align="center" colspan="1" rowspan="1">Percentage of
                                <break/>respondents (N=1927)</th>
                        </tr>
                        <tr>
                            <th align="left" colspan="1" rowspan="1">Age group</th>
                            <th colspan="1" rowspan="1"/>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">15&#x2013;24</td>
                            <td align="center" colspan="1" rowspan="1">22.4</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">25&#x2013;34</td>
                            <td align="center" colspan="1" rowspan="1">41.0</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">35+</td>
                            <td align="center" colspan="1" rowspan="1">36.6</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">
                                <bold>Mean (SD)</bold>
                            </td>
                            <td align="center" colspan="1" rowspan="1">
                                <bold>31.3 (7.9)</bold>
                            </td>
                        </tr>
                        <tr>
                            <th align="left" colspan="1" rowspan="1">Highest level of education</th>
                            <th colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Never attended</td>
                            <td align="center" colspan="1" rowspan="1">9.1</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Primary</td>
                            <td align="center" colspan="1" rowspan="1">17.1</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Secondary</td>
                            <td align="center" colspan="1" rowspan="1">49.7</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Higher</td>
                            <td align="center" colspan="1" rowspan="1">24.1</td>
                        </tr>
                        <tr>
                            <th align="left" colspan="1" rowspan="1">Marital status</th>
                            <th colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Currently married</td>
                            <td align="center" colspan="1" rowspan="1">76.6</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Divorced or separated</td>
                            <td align="center" colspan="1" rowspan="1">2.4</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Widow</td>
                            <td align="center" colspan="1" rowspan="1">1.7</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Never married</td>
                            <td align="center" colspan="1" rowspan="1">19.3</td>
                        </tr>
                        <tr>
                            <th align="left" colspan="1" rowspan="1">Place of residence</th>
                            <th colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Urban</td>
                            <td align="center" colspan="1" rowspan="1">59.0</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Rural</td>
                            <td align="center" colspan="1" rowspan="1">41.0</td>
                        </tr>
                        <tr>
                            <th align="left" colspan="1" rowspan="1">Wealth index</th>
                            <th colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Poor</td>
                            <td align="center" colspan="1" rowspan="1">35.6</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Middle</td>
                            <td align="center" colspan="1" rowspan="1">21.3</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Rich</td>
                            <td align="center" colspan="1" rowspan="1">43.1</td>
                        </tr>
                        <tr>
                            <th align="left" colspan="1" rowspan="1">Number of children at first
                                <break/>use of family planning</th>
                            <th colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">None</td>
                            <td align="center" colspan="1" rowspan="1">31.2</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">1&#x2013;4</td>
                            <td align="center" colspan="1" rowspan="1">52.6</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">5+</td>
                            <td align="center" colspan="1" rowspan="1">16.2</td>
                        </tr>
                    </tbody>
                </table>
            </table-wrap>
            <p>The method mix of the respondents and percentage distribution is shown in 
                <xref ref-type="fig" rid="f1">Figure 1</xref>. Respondents included those who were married to or living with a man at the time of the survey and were currently using contraception.</p>
            <fig fig-type="figure" id="f1" orientation="portrait" position="float">
                <label>Figure 1. </label>
                <caption>
                    <title>Method Mix of current user.</title>
                </caption>
                <graphic orientation="portrait" position="float" xlink:href="https://gatesopenresearch-files.f1000.com/manuscripts/14313/6dedfd05-63c5-4bed-a7b7-5fc284a9f257_figure1.gif"/>
            </fig>
            <p>
                <xref ref-type="table" rid="T2">Table 2</xref>  presents the confidence interval showing respondents rate of using LARC. A total observation of 1927 were considered with 0.15 mean, 0.0081 standard error and confidence interval of 0.0081 - 0.1638</p>
            <table-wrap id="T2" orientation="portrait" position="anchor">
                <label>Table 2. </label>
                <caption>
                    <title>Use of LARC with their 95% Confidence intervals.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="1">Variable</th>
                            <th align="left" colspan="1" rowspan="1">Observation</th>
                            <th align="left" colspan="1" rowspan="1">Mean</th>
                            <th align="left" colspan="1" rowspan="1">Std.Err.</th>
                            <th align="right" colspan="1" rowspan="1">95% CI</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td colspan="1" rowspan="1">LARC use</td>
                            <td colspan="1" rowspan="1">1927</td>
                            <td colspan="1" rowspan="1">0.15</td>
                            <td colspan="1" rowspan="1">0.0081</td>
                            <td align="right" colspan="1" rowspan="1">0.1320 &#x2013; 0.1638</td>
                        </tr>
                    </tbody>
                </table>
            </table-wrap>
            <p>
                <xref ref-type="table" rid="T3">Table 3</xref> presents respondent&#x2019;s contraceptives awareness and knowledge of LARC methods. The table shows that 28.5% read about family planning in newspaper/magazine, 49.7% heard about it on television and 67.2% heard on radio. Concerning awareness at health facility and from health worker, 53.6% of the respondents reported that they were talked to about family planning at the health facility and only 18.5% heard about family planning when visited by health worker in the last 12 months. Knowledge about LARC shows that 70.3% of women in the study had knowledge of the contraceptive implant and 55.5% female had knowledge of the IUD.</p>
            <table-wrap id="T3" orientation="portrait" position="anchor">
                <label>Table 3. </label>
                <caption>
                    <title>Awareness of contraceptive methods and knowledge of long-acting contraceptive methods.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="1">Variables</th>
                            <th align="center" colspan="1" rowspan="1">Percentage of
                                <break/>respondents
                                <break/>(N=1927)</th>
                        </tr>
                        <tr>
                            <th align="left" colspan="1" rowspan="1">Read about FP in newspaper/magazine</th>
                            <th colspan="1" rowspan="1"/>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">No</td>
                            <td align="center" colspan="1" rowspan="1">71.5</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Yes</td>
                            <td align="center" colspan="1" rowspan="1">28.5</td>
                        </tr>
                        <tr>
                            <th align="left" colspan="1" rowspan="1">Heard about FP on television</th>
                            <th colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">No</td>
                            <td align="center" colspan="1" rowspan="1">50.3</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Yes</td>
                            <td align="center" colspan="1" rowspan="1">49.7</td>
                        </tr>
                        <tr>
                            <th align="left" colspan="1" rowspan="1">Heard about FP on radio</th>
                            <th colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">No</td>
                            <td align="center" colspan="1" rowspan="1">32.8</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Yes</td>
                            <td align="center" colspan="1" rowspan="1">67.2</td>
                        </tr>
                        <tr>
                            <th align="left" colspan="1" rowspan="1">Talked to about FP at health facility</th>
                            <th colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">No</td>
                            <td align="center" colspan="1" rowspan="1">46.4</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Yes</td>
                            <td align="center" colspan="1" rowspan="1">53.6</td>
                        </tr>
                        <tr>
                            <th align="left" colspan="1" rowspan="1">Visited by health worker about FP
                                <break/>last 12 months</th>
                            <th colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">No</td>
                            <td align="center" colspan="1" rowspan="1">81.5</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Yes</td>
                            <td align="center" colspan="1" rowspan="1">18.5</td>
                        </tr>
                        <tr>
                            <th align="left" colspan="1" rowspan="1">Ever heard of implants</th>
                            <th colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">No</td>
                            <td align="center" colspan="1" rowspan="1">29.7</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Yes</td>
                            <td align="center" colspan="1" rowspan="1">70.3</td>
                        </tr>
                        <tr>
                            <th align="left" colspan="1" rowspan="1">Ever heard of intrauterine device</th>
                            <th colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">No</td>
                            <td align="center" colspan="1" rowspan="1">44.5</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Yes</td>
                            <td align="center" colspan="1" rowspan="1">55.5</td>
                        </tr>
                    </tbody>
                </table>
                <table-wrap-foot>
                    <fn>
                        <p>FP, family planning.</p>
                    </fn>
                </table-wrap-foot>
            </table-wrap>
            <p>
                <xref ref-type="table" rid="T4">Table 4</xref> presents practice of contraceptives among female who are currently using any method of contraception. The table shows that (76.5%) female that are currently using any method of contraception were using modern contraceptives (e.g. condoms, hormonal pill), and 14.8% of respondents were using LARC.</p>
            <table-wrap id="T4" orientation="portrait" position="anchor">
                <label>Table 4. </label>
                <caption>
                    <title>Contraceptive use.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="1">Variables</th>
                            <th align="center" colspan="1" rowspan="1">Percentage of
                                <break/>respondents (N=1927)</th>
                        </tr>
                        <tr>
                            <th align="left" colspan="1" rowspan="1">Current use of modern
                                <break/>contraceptive method</th>
                            <th colspan="1" rowspan="1"/>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">No</td>
                            <td align="center" colspan="1" rowspan="1">23.5</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Yes</td>
                            <td align="center" colspan="1" rowspan="1">76.5</td>
                        </tr>
                        <tr>
                            <th align="left" colspan="1" rowspan="1">Current use of traditional
                                <break/>contraceptive method</th>
                            <th colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">No</td>
                            <td align="center" colspan="1" rowspan="1">79.0</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Yes</td>
                            <td align="center" colspan="1" rowspan="1">21.0</td>
                        </tr>
                        <tr>
                            <th align="left" colspan="1" rowspan="1">Current use of long acting
                                <break/>reversible contraceptive method</th>
                            <th colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">No</td>
                            <td align="center" colspan="1" rowspan="1">85.2</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Yes</td>
                            <td align="center" colspan="1" rowspan="1">14.8</td>
                        </tr>
                    </tbody>
                </table>
            </table-wrap>
            <p>
                <xref ref-type="table" rid="T5">Table 5</xref> presents pattern of LARC use among current user of contraceptive by selected socio-demographic characteristics. The table showed that LARC use increases as the respondent&#x2019;s reproductive age increases. More women who reside in urban areas were using LARCs compared to those in rural areas. More women with secondary education used LARC methods compared to women with no education, primary and higher education. Marital status shows that married women prefer LARC compared to divorced/separated, widow and never married. With respect to the household wealth index, the table shows that more women from poor households subscribed to LARC method compared to women from middle and rich household. Lastly, number of children at the time respondent started using contraceptive shows that more women that had 1&#x2013;4 children subscribed to LARC methods compare to women with no child and women with more than four children.</p>
            <table-wrap id="T5" orientation="portrait" position="anchor">
                <label>Table 5. </label>
                <caption>
                    <title>Pattern of use (long-acting reversible contraceptive method).</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="1">Variables</th>
                            <th align="center" colspan="1" rowspan="1">Percentage of
                                <break/>respondents (N=285)</th>
                        </tr>
                        <tr>
                            <th align="left" colspan="1" rowspan="1">Age group</th>
                            <th colspan="1" rowspan="1"/>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">15&#x2013;24</td>
                            <td align="center" colspan="1" rowspan="1">9.8</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">25&#x2013;34</td>
                            <td align="center" colspan="1" rowspan="1">44.6</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">35+</td>
                            <td align="center" colspan="1" rowspan="1">45.6</td>
                        </tr>
                        <tr>
                            <th align="left" colspan="1" rowspan="1">Place of residence</th>
                            <th colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Urban</td>
                            <td align="center" colspan="1" rowspan="1">51.6</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Rural</td>
                            <td align="center" colspan="1" rowspan="1">48.4</td>
                        </tr>
                        <tr>
                            <th align="left" colspan="1" rowspan="1">Highest level of education</th>
                            <th colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Never attended</td>
                            <td align="center" colspan="1" rowspan="1">8.8</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Primary</td>
                            <td align="center" colspan="1" rowspan="1">20.0</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Secondary</td>
                            <td align="center" colspan="1" rowspan="1">48.4</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Higher</td>
                            <td align="center" colspan="1" rowspan="1">22.8</td>
                        </tr>
                        <tr>
                            <th align="left" colspan="1" rowspan="1">Marital status</th>
                            <th colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Currently married</td>
                            <td align="center" colspan="1" rowspan="1">93.7</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Divorced or separated</td>
                            <td align="center" colspan="1" rowspan="1">2.1</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Widow</td>
                            <td align="center" colspan="1" rowspan="1">2.5</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Never married</td>
                            <td align="center" colspan="1" rowspan="1">1.7</td>
                        </tr>
                        <tr>
                            <th align="left" colspan="1" rowspan="1">Household Wealth index</th>
                            <th colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Poor</td>
                            <td align="center" colspan="1" rowspan="1">43.5</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Middle</td>
                            <td align="center" colspan="1" rowspan="1">18.3</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Rich</td>
                            <td align="center" colspan="1" rowspan="1">38.2</td>
                        </tr>
                        <tr>
                            <th align="left" colspan="1" rowspan="1">Number of children at first use of
                                <break/>family planning</th>
                            <th colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">None</td>
                            <td align="center" colspan="1" rowspan="1">6.0</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">1&#x2013;4</td>
                            <td align="center" colspan="1" rowspan="1">66.3</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">5+</td>
                            <td align="center" colspan="1" rowspan="1">27.7</td>
                        </tr>
                    </tbody>
                </table>
            </table-wrap>
            <p>
                <xref ref-type="table" rid="T6">Table 6</xref> presents the association between knowledge of LARC and use of LARC methods among women that are currently using contraception. The table showed that at both levels of analyses (binary and multivariable logistic regression) there is a significant relationship (P&lt;0.05 and P=0.00, respectively) between knowledge of LARC and it uses in this study. This means that the use of LARC can be influenced by knowledge of it among women of reproductive age in Nigeria.</p>
            <table-wrap id="T6" orientation="portrait" position="anchor">
                <label>Table 6. </label>
                <caption>
                    <title>Association between knowledge and use of long-acting reversible contraceptives (LARCs).</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="1">Variables</th>
                            <th align="center" colspan="3" rowspan="1">Use of LARCs</th>
                        </tr>
                        <tr>
                            <th align="left" colspan="1" rowspan="1">Ever heard of
                                <break/>implant</th>
                            <th align="left" colspan="1" rowspan="1">No, %
                                <break/>(n=1,642)</th>
                            <th align="left" colspan="1" rowspan="1">Yes, %
                                <break/>(n=285)</th>
                            <th align="left" colspan="1" rowspan="1">Total, %
                                <break/>(N=1,927)</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">No</td>
                            <td align="center" colspan="1" rowspan="1">34.4</td>
                            <td align="center" colspan="1" rowspan="1">3.2</td>
                            <td align="center" colspan="1" rowspan="1">29.7</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Yes</td>
                            <td align="center" colspan="1" rowspan="1">65.6</td>
                            <td align="center" colspan="1" rowspan="1">96.8</td>
                            <td align="center" colspan="1" rowspan="1">70.3</td>
                        </tr>
                        <tr>
                            <td colspan="1" rowspan="1"/>
                            <td align="center" colspan="3" rowspan="1">
                                <bold>X
                                    <sup>2</sup>=113.1, P=0.000
                                    <xref ref-type="other" rid="tfn1">*</xref>
                                </bold>
                            </td>
                        </tr>
                        <tr>
                            <th align="left" colspan="1" rowspan="1">Ever heard of
                                <break/>IUD</th>
                            <th colspan="1" rowspan="1"/>
                            <th colspan="1" rowspan="1"/>
                            <th colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">No</td>
                            <td align="center" colspan="1" rowspan="1">47.0</td>
                            <td align="center" colspan="1" rowspan="1">30.2</td>
                            <td align="center" colspan="1" rowspan="1">44.5</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Yes</td>
                            <td align="center" colspan="1" rowspan="1">53.0</td>
                            <td align="center" colspan="1" rowspan="1">69.8</td>
                            <td align="center" colspan="1" rowspan="1">55.5</td>
                        </tr>
                        <tr>
                            <td colspan="1" rowspan="1"/>
                            <td align="center" colspan="3" rowspan="1">
                                <bold>X
                                    <sup>2</sup>=27.9, P=0.000
                                    <xref ref-type="other" rid="tfn1">*</xref>
                                </bold>
                            </td>
                        </tr>
                    </tbody>
                </table>
                <table-wrap-foot>
                    <fn>
                        <p id="tfn1">*Significant at P &lt; 0.05. IUD, intrauterine device.</p>
                    </fn>
                </table-wrap-foot>
            </table-wrap>
            <p>Logistic regression was employed to assess the net effect of selected variable theoretically related to use of LARC methods in 
                <xref ref-type="table" rid="T7">Table 7</xref>. The result of logistic regression showed that women who were 25 years and above, women with secondary and higher education, currently married and widow, women from rich household and women with one or more children were significantly associated with use of LARC methods.</p>
            <table-wrap id="T7" orientation="portrait" position="anchor">
                <label>Table 7. </label>
                <caption>
                    <title>Factors influencing use of long acting reversible contraceptive method.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="1">Variables</th>
                            <th align="center" colspan="1" rowspan="1">Odds
                                <break/>ratio</th>
                            <th align="center" colspan="1" rowspan="1">P-value</th>
                            <th align="center" colspan="1" rowspan="1">Confidence interval</th>
                        </tr>
                        <tr>
                            <th align="left" colspan="4" rowspan="1">Age group (RC=15&#x2013;24)</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">25&#x2013;34</td>
                            <td align="center" colspan="1" rowspan="1">1.67</td>
                            <td align="center" colspan="1" rowspan="1">0.05</td>
                            <td align="center" colspan="1" rowspan="1">0.9864-2.8171</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">35+</td>
                            <td align="center" colspan="1" rowspan="1">1.73</td>
                            <td align="center" colspan="1" rowspan="1">0.05</td>
                            <td align="center" colspan="1" rowspan="1">0.9849-3.0308</td>
                        </tr>
                        <tr>
                            <th align="left" colspan="4" rowspan="1">Place of residence (RC=Rural)</th>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Urban</td>
                            <td align="center" colspan="1" rowspan="1">0.92</td>
                            <td align="center" colspan="1" rowspan="1">0.70</td>
                            <td align="center" colspan="1" rowspan="1">0.6088-1.3919</td>
                        </tr>
                        <tr>
                            <th align="left" colspan="4" rowspan="1">Highest level of education (RC=Never attended)</th>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Primary</td>
                            <td align="center" colspan="1" rowspan="1">1.68</td>
                            <td align="center" colspan="1" rowspan="1">0.11</td>
                            <td align="center" colspan="1" rowspan="1">0.8826-3.2143</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Secondary</td>
                            <td align="center" colspan="1" rowspan="1">2.64</td>
                            <td align="center" colspan="1" rowspan="1">0.00</td>
                            <td align="center" colspan="1" rowspan="1">1.4122-4.9475</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Higher</td>
                            <td align="center" colspan="1" rowspan="1">3.30</td>
                            <td align="center" colspan="1" rowspan="1">0.00</td>
                            <td align="center" colspan="1" rowspan="1">1.5973-6.8293</td>
                        </tr>
                        <tr>
                            <th align="left" colspan="4" rowspan="1">Marital status (RC=Never married)</th>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Currently married</td>
                            <td align="center" colspan="1" rowspan="1">4.61</td>
                            <td align="center" colspan="1" rowspan="1">0.01</td>
                            <td align="center" colspan="1" rowspan="1">1.3566-15.6591</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Divorced/separated</td>
                            <td align="center" colspan="1" rowspan="1">2.41</td>
                            <td align="center" colspan="1" rowspan="1">0.32</td>
                            <td align="center" colspan="1" rowspan="1">0.4298-13.5370</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Widow</td>
                            <td align="center" colspan="1" rowspan="1">7.16</td>
                            <td align="center" colspan="1" rowspan="1">0.01</td>
                            <td align="center" colspan="1" rowspan="1">1.4163-36.2025</td>
                        </tr>
                        <tr>
                            <th align="left" colspan="4" rowspan="1">Household wealth (RC=Poor)</th>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Middle</td>
                            <td align="center" colspan="1" rowspan="1">0.88</td>
                            <td align="center" colspan="1" rowspan="1">0.61</td>
                            <td align="center" colspan="1" rowspan="1">0.5327-1.4458</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Rich</td>
                            <td align="center" colspan="1" rowspan="1">0.57</td>
                            <td align="center" colspan="1" rowspan="1">0.03</td>
                            <td align="center" colspan="1" rowspan="1">0.3432-0.9442</td>
                        </tr>
                        <tr>
                            <th align="left" colspan="4" rowspan="1">Number of children at first use of family planning
                                <break/>(RC=None)</th>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">1&#x2013;4</td>
                            <td align="center" colspan="1" rowspan="1">4.28</td>
                            <td align="center" colspan="1" rowspan="1">0.00</td>
                            <td align="center" colspan="1" rowspan="1">2.2500-8.1412</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">5+</td>
                            <td align="center" colspan="1" rowspan="1">6.08</td>
                            <td align="center" colspan="1" rowspan="1">0.00</td>
                            <td align="center" colspan="1" rowspan="1">2.9560-12.5079</td>
                        </tr>
                        <tr>
                            <th align="left" colspan="4" rowspan="1">Family planning discussion at facility (RC=No)</th>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Yes</td>
                            <td align="center" colspan="1" rowspan="1">1.38</td>
                            <td align="center" colspan="1" rowspan="1">0.06</td>
                            <td align="center" colspan="1" rowspan="1">0.9832-1.9499</td>
                        </tr>
                        <tr>
                            <th align="left" colspan="4" rowspan="1">Visited by health worker (RC=No)</th>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">Yes</td>
                            <td align="center" colspan="1" rowspan="1">0.82</td>
                            <td align="center" colspan="1" rowspan="1">0.32</td>
                            <td align="center" colspan="1" rowspan="1">0.5617-1.2041</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1">
                                <bold>Constant</bold>
                            </td>
                            <td align="center" colspan="1" rowspan="1">
                                <bold>0.00</bold>
                            </td>
                            <td align="center" colspan="1" rowspan="1">
                                <bold>0.00</bold>
                            </td>
                            <td align="center" colspan="1" rowspan="1">
                                <bold>0.0011-0.0177</bold>
                            </td>
                        </tr>
                    </tbody>
                </table>
                <table-wrap-foot>
                    <fn>
                        <p>
                            <bold>RC, recode.</bold>
                        </p>
                    </fn>
                </table-wrap-foot>
            </table-wrap>
            <p>Women who fall between the ages of 25 and 34 years were 1.67 times more likely to use LARC methods than those who aged 15&#x2013;24 years, and those women that 35 years and above were 1.73 times more likely to use LARC methods than those aged 15&#x2013;24 years.</p>
            <p>Level of education shows that women with secondary school education were 2.64 times more likely to use LARC methods than those that never attended school and those women with higher education were 3.30 times more likely to use LARC methods than those that never attended school in the study. Concerning marital status, the results show that married women were 4.61 times more likely to use LARC methods than those that never married and widowed women were 7.16 times more likely to use LARC methods than those that never married.</p>
            <p>With respect to household wealth index, women from rich households were 0.57 times less likely to use LARC methods than women from poor households. In addition, women with 1&#x2013;4 children at the time of contraceptive use were 4.28 times more likely to use LARC methods than women with no child and women with more than 4 children at the time of contraceptive use were 6.08 times more likely to use LARC methods than women with no child. Lastly, women who heard about family planning at health facility were 1.38 times more likely to use LARC methods than those that heard it elsewhere.</p>
        </sec>
        <sec sec-type="discussion">
            <title>Discussion</title>
            <p>This paper assessed knowledge of LARC and factors influencing the use of LARC among women that are currently using contraception in Nigeria. The study showed that LARCs were largely under-used among women that are currently using any contraception. To properly harness socio-economic opportunities and better child spacing the low use of LARC should be tackled because of its integral benefit of meeting women&#x2019;s reproductive needs in a context where woman are redefining their reproductive life style
                <sup>
                    <xref ref-type="bibr" rid="ref-4">4</xref>,
                    <xref ref-type="bibr" rid="ref-15">15</xref>
                </sup>.</p>
            <p>This study shows that there was an association between women&#x2019;s knowledge of LARCs and use of LARCs among women that are currently using contraception. This is because women&#x2019;s knowledge about the efficacy and safety of LARC methods may strongly influence both the selection and decision to continue to use the selected method over time. These findings were in line with previous studies that say women will opt for LARC methods as their contraceptive method of choice when they have knowledge of the method
                <sup>
                    <xref ref-type="bibr" rid="ref-3">3</xref>,
                    <xref ref-type="bibr" rid="ref-6">6</xref>,
                    <xref ref-type="bibr" rid="ref-7">7</xref>,
                    <xref ref-type="bibr" rid="ref-16">16</xref>&#x2013;
                    <xref ref-type="bibr" rid="ref-20">20</xref>
                </sup>. Another study also affirmed that women reproductive life plans are being altered as result of misinformation and this prompt woman to adopt methods not suitable for themselves
                <sup>
                    <xref ref-type="bibr" rid="ref-21">21</xref>
                </sup>.</p>
            <p>In addition, level of education was found to be associated with the use of LARC. The possibility of women with atleast secondary school education to control her reproductive need is very high. The higher the education of women the higher the propensity that they will adopt the use of LARC. Previous studies also corroborate this point that better educated women have access to information on modern contraceptive which may trigger their interest in the use of LARC
                <sup>
                    <xref ref-type="bibr" rid="ref-6">6</xref>,
                    <xref ref-type="bibr" rid="ref-18">18</xref>,
                    <xref ref-type="bibr" rid="ref-19">19</xref>,
                    <xref ref-type="bibr" rid="ref-22">22</xref>&#x2013;
                    <xref ref-type="bibr" rid="ref-26">26</xref>
                </sup>.</p>
            <p>Women aged 25 years and above were more likely to use LARC methods as compared to women aged 15&#x2013;24 years. This result is in line with previous studies, which reported that age of mothers was found to be associated with the use of LARC because the prevalence of LARC use increased with age
                <sup>
                    <xref ref-type="bibr" rid="ref-3">3</xref>,
                    <xref ref-type="bibr" rid="ref-4">4</xref>,
                    <xref ref-type="bibr" rid="ref-23">23</xref>,
                    <xref ref-type="bibr" rid="ref-24">24</xref>,
                    <xref ref-type="bibr" rid="ref-26">26</xref>
                </sup>.</p>
            <p>Number of living children at the time of contraceptive use was significantly associated with LARC use. Suggesting that women wanted to space or limit childbirth as the number of surviving children increases. The higher the number of living children the higher the possibility of adopting LARC. The desire to limit the number of children will automatically come to play when women believe they have sufficient numbers of children so rather than adopting short-lasting, long-lasting methods will be preferred
                <sup>
                    <xref ref-type="bibr" rid="ref-4">4</xref>,
                    <xref ref-type="bibr" rid="ref-22">22</xref>,
                    <xref ref-type="bibr" rid="ref-23">23</xref>,
                    <xref ref-type="bibr" rid="ref-27">27</xref>
                </sup>.</p>
            <p>Furthermore, women from rich households were less likely to use LARCs. This is in contrary with other studies, which found that household wealth has a positive association with the use and wealthier women were more likely to use LARC than poorer women
                <sup>
                    <xref ref-type="bibr" rid="ref-4">4</xref>,
                    <xref ref-type="bibr" rid="ref-23">23</xref>,
                    <xref ref-type="bibr" rid="ref-24">24</xref>
                </sup>.</p>
            <p>Lastly, the study found that married women were more likely to use LARC methods. This is consistent with previous studies that showed that married women have good attitudes towards using LARC methods
                <sup>
                    <xref ref-type="bibr" rid="ref-17">17</xref>,
                    <xref ref-type="bibr" rid="ref-24">24</xref>,
                    <xref ref-type="bibr" rid="ref-28">28</xref>
                </sup>.</p>
            <sec>
                <title>Limitations</title>
                <p>This study was conducted among women of reproductive age who are currently using contraception, which might not reflect a holistic view of all women of reproductive age in Nigeria. In addition, the cross-sectional design used to collect the data comes with major limitations allowing us with mere hypotheses than real cause effect relationships.</p>
            </sec>
            <sec>
                <title>Future suggestions</title>
                <p>The study showed that LARCs were largely under-used among women that are currently using contraception in Nigeria. To properly harness socio-economic opportunities and better child spacing, the low use of LARC should be tackled because of its integral benefit of meeting women&#x2019;s reproductive needs in a context where women are redefining their reproductive life style. Therefore, women with lower educational level, high wealth index, and higher number of living children should be targeted by program strategies to control childbearing. Also, there is need for a communication strategy that would provide correct information about LARC safety and effectiveness among women of reproductive age. Lastly, when discussing contraception with women, health care practitioners should discuss the risks and benefits of LARCs with women of all ages and recommend them as a first line method.</p>
            </sec>
        </sec>
        <sec sec-type="conclusions">
            <title>Conclusions</title>
            <p>In conclusion, findings from this study showed that 14.8% of women in Nigeria that are currently using contraception were using LARC. Additionally, level of education, age of women, household wealth and number of living children as at the time of contraceptive use were significantly associated with the use of LARC. Also, knowledge of LARC was significantly associated with LARC use. To effectively control the childbearing in Nigeria women with lower education, high wealth index and high number of living children should be the target audience among the women of reproductive age in Nigeria. Also, there is need for a communication strategy that would provide correct information about LARC safety and effectiveness among women of reproductive age. Lastly, when discussing contraception with women, health care practitioners should discuss the risks and benefits of LARC with women of all ages and recommend them as a first-line method.</p>
        </sec>
        <sec>
            <title>Data availability</title>
            <sec>
                <title>Underlying data</title>
                <p>Raw data associated with this study are available on OSF. DOI: 
                    <ext-link ext-link-type="uri" xlink:href="https://dx.doi.org/10.17605/OSF.IO/C5YGV">https://doi.org/10.17605/OSF.IO/C5YGV</ext-link>
                    <sup>
                        <xref ref-type="bibr" rid="ref-14">14</xref>
                    </sup>.</p>
            </sec>
            <sec>
                <title>Extended data</title>
                <p>Questionnaires used in this study are available on OSF. DOI: 
                    <ext-link ext-link-type="uri" xlink:href="https://dx.doi.org/10.17605/OSF.IO/C5YGV">https://doi.org/10.17605/OSF.IO/C5YGV</ext-link>
                    <sup>
                        <xref ref-type="bibr" rid="ref-14">14</xref>
                    </sup>.</p>
                <p>Data are available under the terms of the 
                    <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">Creative Commons Zero "No rights reserved" data waiver</ext-link> (CC0 1.0 Public domain dedication).</p>
            </sec>
        </sec>
    </body>
    <back>
        <ref-list>
            <ref id="ref-1">
                <label>1</label>
                <mixed-citation publication-type="journal">
                    <article-title>Adolescents and Long-Acting Reversible Contraception: Implants and Intrauterine Devices.</article-title>ACOG Committee Decision No. 539.<year>2012</year>.
                    <ext-link ext-link-type="uri" xlink:href="https://www.acog.org/Clinical-Guidance-and-Publications/Committee-Opinions/Committee-on-Adolescent-Health-Care/Adolescents-and-Long-Acting-Reversible-Contraception?IsMobileSet=false">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref-2">
                <label>2</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Stoddard</surname>
                            <given-names>A</given-names>
                        </name>

                        <name name-style="western">
                            <surname>McNicholas</surname>
                            <given-names>C</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Peipert</surname>
                            <given-names>JF</given-names>
                        </name>
</person-group>:
                    <article-title>Efficacy and safety of long-acting reversible contraception.</article-title>
                    <source>

                        <italic toggle="yes">Drugs.</italic>
</source>
                    <year>2011</year>;<volume>71</volume>(<issue>8</issue>):<fpage>969</fpage>&#x2013;<lpage>980</lpage>.
                    <pub-id pub-id-type="pmid">21668037</pub-id>
                    <pub-id pub-id-type="doi">10.2165/11591290-000000000-00000</pub-id>
                    <pub-id pub-id-type="pmcid">3662967</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref-3">
                <label>3</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Branum</surname>
                            <given-names>AM</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Jones</surname>
                            <given-names>J</given-names>
                        </name>
</person-group>:
                    <article-title>Trends in long-acting reversible contraception use among U.S. women aged 15-44.</article-title>
                    <source>

                        <italic toggle="yes">NCHS Data Brief.</italic>
</source>
                    <year>2015</year>; (<issue>188</issue>):<fpage>1</fpage>&#x2013;<lpage>8</lpage>.
                    <pub-id pub-id-type="pmid">25714042</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref-4">
                <label>4</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Moreau</surname>
                            <given-names>C</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Bohet</surname>
                            <given-names>A</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Hassoun</surname>
                            <given-names>D</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Trends and determinants of use of long-acting reversible contraception use among young women in France: results from three national surveys conducted between 2000 and 2010.</article-title>
                    <source>

                        <italic toggle="yes">Fertil Steril.</italic>
</source>
                    <year>2013</year>;<volume>100</volume>(<issue>2</issue>):<fpage>451</fpage>&#x2013;<lpage>8</lpage>.
                    <pub-id pub-id-type="pmid">23663994</pub-id>
                    <pub-id pub-id-type="doi">10.1016/j.fertnstert.2013.04.002</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref-5">
                <label>5</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Bradley</surname>
                            <given-names>SEK</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Croft</surname>
                            <given-names>TN</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Rutstein</surname>
                            <given-names>SP</given-names>
                        </name>
</person-group>:
                    <article-title>The Impact of Contraceptive Failure on Unintended Births and Induced Abortions: Estimates and Strategies for Reduction.</article-title>DHS Analytical Studies No. 22. Calverton, Maryland, USA: ICF Macro.<year>2011</year>.
                    <ext-link ext-link-type="uri" xlink:href="https://dhsprogram.com/pubs/pdf/AS22/AS22.pdf">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref-6">
                <label>6</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Zenebe</surname>
                            <given-names>CB</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Adefris</surname>
                            <given-names>M</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Yenit</surname>
                            <given-names>MK</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Factors associated with utilization of long-acting and permanent contraceptive methods among women who have decided not to have more children in Gondar city.</article-title>
                    <source>

                        <italic toggle="yes">BMC Womens Health.</italic>
</source>
                    <year>2017</year>;<volume>17</volume>(<issue>1</issue>):<fpage>75</fpage>.
                    <pub-id pub-id-type="pmid">28877687</pub-id>
                    <pub-id pub-id-type="doi">10.1186/s12905-017-0432-9</pub-id>
                    <pub-id pub-id-type="pmcid">5588745</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref-7">
                <label>7</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Belayneh</surname>
                            <given-names>F</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Abreha</surname>
                            <given-names>S</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Meskele</surname>
                            <given-names>M</given-names>
                        </name>
</person-group>:
                    <article-title>Knowledge, Attitude and Factors Associated with the Use of Long Acting and Permanent Contraceptive Methods among Women of Reproductive Age in Gesuba Town, Southern Ethiopia.</article-title>
                    <source>

                        <italic toggle="yes">Journal of Biology, Agriculture and Healthcare.</italic>
</source>
                    <year>2015</year>;<volume>5</volume>(<issue>21</issue>).</mixed-citation>
            </ref>
            <ref id="ref-8">
                <label>8</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Adedini</surname>
                            <given-names>SA</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Omisakin</surname>
                            <given-names>OA</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Somefun</surname>
                            <given-names>OD</given-names>
                        </name>
</person-group>:
                    <article-title>Trends, patterns and determinants of long-acting reversible methods of contraception among women in sub-Saharan Africa.</article-title>
                    <source>

                        <italic toggle="yes">PLoS One.</italic>
</source>
                    <year>2019</year>;<volume>14</volume>(<issue>6</issue>):<fpage>e0217574</fpage>.
                    <pub-id pub-id-type="pmid">31163050</pub-id>
                    <pub-id pub-id-type="doi">10.1371/journal.pone.0217574</pub-id>
                    <pub-id pub-id-type="pmcid">6548375</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref-9">
                <label>9</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Skiles</surname>
                            <given-names>MP</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Cunningham</surname>
                            <given-names>M</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Inglis</surname>
                            <given-names>A</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>The effect of access to contraceptive services on injectable use and demand for family planning in Malawi.</article-title>
                    <source>

                        <italic toggle="yes">Int Perspect Sex Reprod Health.</italic>
</source>
                    <year>2015</year>;<volume>41</volume>(<issue>1</issue>):<fpage>20</fpage>&#x2013;<lpage>30</lpage>.
                    <pub-id pub-id-type="pmid">25856234</pub-id>
                    <pub-id pub-id-type="doi">10.1363/4102015</pub-id>
                    <pub-id pub-id-type="pmcid">4863240</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref-10">
                <label>10</label>
                <mixed-citation publication-type="journal">
                    <article-title>Nigeria Demographic and Health Survey</article-title>.<year>2018</year>.
                    <ext-link ext-link-type="uri" xlink:href="https://www.dhsprogram.com/pubs/pdf/FR359/FR359.pdf">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref-11">
                <label>11</label>
                <mixed-citation publication-type="journal">
                    <article-title>Nigeria Demographic and Health Survey</article-title>.<year>2013</year>.
                    <ext-link ext-link-type="uri" xlink:href="https://dhsprogram.com/pubs/pdf/fr293/fr293.pdf">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref-12">
                <label>12</label>
                <mixed-citation publication-type="journal">
                    <article-title>Performance, Monitoring and Accountability 2020 (PMA2020) Project, Obafemi Awolowo University, Ile Ife and Bayero University, Kano. 2016</article-title>. Nigeria. Baltimore, MD PMA2020, Bill &amp; Melinda Gates Institute for Population and Reproductive Health, Johns Hopkins Bloomberg School of Public Health. (PMA 2016).
                    <ext-link ext-link-type="uri" xlink:href="https://www.pma2020.org/sites/default/files/PMA2020_Progress_Report_2017_DIGITAL-2017.01.23.pdf">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref-13">
                <label>13</label>
                <mixed-citation publication-type="journal">
                    <article-title>PMA2020 Nigeria methodology</article-title>.
                    <ext-link ext-link-type="uri" xlink:href="https://www.pmadata.org/data/survey-methodology">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref-14">
                <label>14</label>
                <mixed-citation publication-type="data">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Bolarinwa</surname>
                            <given-names>OA</given-names>
                        </name>
</person-group>:
                    <article-title>Knowledge and factors influencing long acting reversible contraceptive use among women of reproductive age in Nigeria</article-title>.<year>2019</year>.
                    <ext-link ext-link-type="uri" xlink:href="http://www.doi.org/10.17605/OSF.IO/C5YGV">http://www.doi.org/10.17605/OSF.IO/C5YGV</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref-15">
                <label>15</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Kavanaugh</surname>
                            <given-names>ML</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Jerman</surname>
                            <given-names>J</given-names>
                        </name>

                        <name name-style="western">
                            <surname> Finer</surname>
                            <given-names>LB</given-names>
                        </name>
</person-group>:
                    <article-title>Changes in Use of Long-Acting Reversible Contraceptive Methods among U.S. Women, 2009-2012.</article-title>
                    <source>

                        <italic toggle="yes">Obstet Gynecol.</italic>
</source>
                    <year>2015</year>;<volume>126</volume>(<issue>5</issue>):<fpage>917</fpage>&#x2013;<fpage>927</fpage>.
                    <pub-id pub-id-type="pmid">26444110</pub-id>
                    <pub-id pub-id-type="doi">10.1097/AOG.0000000000001094</pub-id>
                    <pub-id pub-id-type="pmcid">4946164</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref-16">
                <label>16</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Biza</surname>
                            <given-names>N</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Abdu</surname>
                            <given-names>M</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Reddy</surname>
                            <given-names>PS</given-names>
                        </name>
</person-group>:
                    <article-title>Long acting reversible contraceptive use and associated factors among contraceptive users in Amhara region, Ethiopia. A community based cross sectional study.</article-title>
                    <source>

                        <italic toggle="yes">Medico Research Chronicles.</italic>
</source>
                    <year>2016</year>.</mixed-citation>
            </ref>
            <ref id="ref-17">
                <label>17</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Anguzu</surname>
                            <given-names>R</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Tweheyo</surname>
                            <given-names>R</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Sekandi</surname>
                            <given-names>JN</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Knowledge and attitudes towards use of long acting reversible contraceptives among women of reproductive age in Lubaga division, Kampala district, Uganda.</article-title>
                    <source>

                        <italic toggle="yes">BMC Res Notes.</italic>
</source>
                    <year>2014</year>;<volume>7</volume>:<fpage>153</fpage>.
                    <pub-id pub-id-type="pmid">24636154</pub-id>
                    <pub-id pub-id-type="doi">10.1186/1756-0500-7-153</pub-id>
                    <pub-id pub-id-type="pmcid">3985592</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref-18">
                <label>18</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Desta</surname>
                            <given-names>SA</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Worku</surname>
                            <given-names>A</given-names>
                        </name>
</person-group>:
                    <article-title>Usage of Long Acting Reversible Contraceptive Methods among Women Who Want No More Children, In-Depth Analysis of the Ethiopian Demographic and Health Survey 2005.</article-title>
                    <source>

                        <italic toggle="yes">Science Journal of Public Health.</italic>
</source>
                    <year>2017</year>;<volume>5</volume>(<issue>6</issue>):<fpage>428</fpage>&#x2013;<lpage>439</lpage>.
                    <pub-id pub-id-type="doi">10.11648/j.sjph.20170506.14</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref-19">
                <label>19</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Getinet</surname>
                            <given-names>S</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Abdrahman</surname>
                            <given-names>MA</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Kemaw</surname>
                            <given-names>N</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Long Acting Contraceptive Method Utilization and Associated Factors among Reproductive Age Women in Arba Minch Town, Ethiopia.</article-title>
                    <source>

                        <italic toggle="yes">Greener Journal of Epidemiology and Public Health.</italic>
</source>
                    <year>2014</year>;<volume>2</volume>(<issue>1</issue>):<fpage>023</fpage>&#x2013;<lpage>031</lpage>.
                    <ext-link ext-link-type="uri" xlink:href="http://gjournals.org/GJEPH/Publication/2014/July/PDF/070514294%20Shegaw%20et%20al.pdf">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref-20">
                <label>20</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Tamrie</surname>
                            <given-names>YE</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Hanna</surname>
                            <given-names>EG</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Argaw</surname>
                            <given-names>MD</given-names>
                        </name>
</person-group>:
                    <article-title>Determinants of Long Acting Reversible Contraception Method Use among Mothers in Extended Postpartum Period, Durame Town, Southern Ethiopia: A Cross Sectional Community Based Survey.</article-title>
                    <source>

                        <italic toggle="yes">Health.</italic>
</source>
                    <year>2015</year>;<volume>7</volume>(<issue>10</issue>):<fpage>1315</fpage>&#x2013;<lpage>1326</lpage>.
                    <pub-id pub-id-type="doi">10.4236/health.2015.710146</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref-21">
                <label>21</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Kakaiya</surname>
                            <given-names>R</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Lopez</surname>
                            <given-names>LL</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Nelson</surname>
                            <given-names>AL</given-names>
                        </name>
</person-group>:
                    <article-title>Women&#x2019;s perceptions of contraceptive efficacy and safety.</article-title>
                    <source>

                        <italic toggle="yes">Contracept Reprod Med.</italic>
</source>
                    <year>2017</year>;<volume>2</volume>:<fpage>19</fpage>.
                    <pub-id pub-id-type="pmid">29201424</pub-id>
                    <pub-id pub-id-type="doi">10.1186/s40834-017-0046-5</pub-id>
                    <pub-id pub-id-type="pmcid">5683240</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref-22">
                <label>22</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Bikorimana</surname>
                            <given-names>E</given-names>
                        </name>
</person-group>:
                    <article-title>Barriers to the use of Long acting contraception methods among married women of reproductive age in Kicukiro District, Rwanda.</article-title>
                    <source>

                        <italic toggle="yes">International Journal of Scientific and Research Publications.</italic>
</source>
                    <year>2015</year>;<volume>5</volume>(<issue>12</issue>).
                    <ext-link ext-link-type="uri" xlink:href="http://www.ijsrp.org/research-paper-1215/ijsrp-p4878.pdf">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref-23">
                <label>23</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Azmoude</surname>
                            <given-names>E</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Behnam</surname>
                            <given-names>H</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Barati-Far</surname>
                            <given-names>S</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Factors Affecting the Use of Long-Acting and Permanent Contraceptive Methods Among Married Women of Reproductive Age in East of Iran.</article-title>
                    <source>

                        <italic toggle="yes">Women&#x2019;s Health Bull.</italic>
</source>
                    <year>2017</year>.
                    <ext-link ext-link-type="uri" xlink:href="https://neoscriber.org/cdn/dl/e786c496-5e53-11e7-9ce8-2f554793bbf3">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref-24">
                <label>24</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Coombe</surname>
                            <given-names>J</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Harris</surname>
                            <given-names>ML</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Loxton</surname>
                            <given-names>D</given-names>
                        </name>
</person-group>:
                    <article-title>Who uses long-acting reversible contraception? Profile of LARC users in the CUPID cohort.</article-title>
                    <source>

                        <italic toggle="yes">Sex Reprod Healthc.</italic>
</source>
                    <year>2017</year>;<volume>11</volume>;<fpage>19</fpage>&#x2013;<lpage>24</lpage>.
                    <pub-id pub-id-type="pmid">28159123</pub-id>
                    <pub-id pub-id-type="doi">10.1016/j.srhc.2016.09.003</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref-25">
                <label>25</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Adako</surname>
                            <given-names>O</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Okunfulure</surname>
                            <given-names>FO</given-names>
                        </name>
</person-group>:
                    <article-title>Demand for Long Acting Reversible Contraceptives and Associated Factors among Women Accessing Family Planning Service in ARFH Model Clinic Ibadan, South West Nigeria.</article-title>
                    <source>

                        <italic toggle="yes">Adv Practice Nurs.</italic>
</source>
                    <year>2016</year>;<volume>1</volume>:<fpage>117</fpage>.
                    <pub-id pub-id-type="doi">10.4172/2573-0347.1000117</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref-26">
                <label>26</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Gudaynhe</surname>
                            <given-names>SW</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Zegeye</surname>
                            <given-names>DT</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Asmamaw</surname>
                            <given-names>T</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Factors Affecting the use of Long-Acting Reversible Contraceptive Methods among Married Women in Debre Markos Town, Northwest Ethiopia.</article-title>
                    <source>

                        <italic toggle="yes">Global Journal of Medical Research: Gynecology and Obstetrics.</italic>
</source>
                    <year>2014</year>;<volume>14</volume>(<issue>5</issue>): Version 1.0 (2014).
                    <ext-link ext-link-type="uri" xlink:href="https://medicalresearchjournal.org/index.php/GJMR/article/view/783/696">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref-27">
                <label>27</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Dassah</surname>
                            <given-names>ET</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Odoi</surname>
                            <given-names>AT</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Owusu-Asubonteng</surname>
                            <given-names>G</given-names>
                        </name>
</person-group>:
                    <article-title>Prevalence and factors predictive of long-acting reversible contraceptive use in a tertiary hospital in urban Ghana.</article-title>
                    <source>

                        <italic toggle="yes">Eur J Contracept Reprod Health Care.</italic>
</source>
                    <year>2013</year>;<volume>18</volume>(<issue>4</issue>):<fpage>293</fpage>&#x2013;<lpage>9</lpage>.
                    <pub-id pub-id-type="pmid">23650905</pub-id>
                    <pub-id pub-id-type="doi">10.3109/13625187.2013.790951</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref-28">
                <label>28</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>White</surname>
                            <given-names>K</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Hopkins</surname>
                            <given-names>K</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Potter</surname>
                            <given-names>JE</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Knowledge and attitudes about long-acting reversible contraception among Latina women who desire sterilization.</article-title>
                    <source>

                        <italic toggle="yes">Womens Health Issues.</italic>
</source>
                    <year>2013</year>;<volume>23</volume>(<issue>4</issue>):<fpage>e257</fpage>&#x2013;<lpage>e263</lpage>.
                    <pub-id pub-id-type="pmid">23816156</pub-id>
                    <pub-id pub-id-type="doi">10.1016/j.whi.2013.05.001</pub-id>
                    <pub-id pub-id-type="pmcid">3707629</pub-id>
                </mixed-citation>
            </ref>
        </ref-list>
    </back>
    <sub-article article-type="reviewer-report" id="report28811">
        <front-stub>
            <article-id pub-id-type="doi">10.21956/gatesopenres.14313.r28811</article-id>
            <title-group>
                <article-title>Reviewer response for version 2</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Anguzu</surname>
                        <given-names>Ronald</given-names>
                    </name>
                    <xref ref-type="aff" rid="r28811a1">1</xref>
                    <role>Referee</role>
                </contrib>
                <aff id="r28811a1">
                    <label>1</label>Public and Community Health Program, Institute for Health and Equity, Medical College of Wisconsin&#x00a0;(MCW), Milwaukee, WI, USA</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>12</day>
                <month>5</month>
                <year>2020</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2020 Anguzu R</copyright-statement>
                <copyright-year>2020</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport28811" related-article-type="peer-reviewed-article" xlink:href="10.12688/gatesopenres.12902.2"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>This article is important in the field of prevention of unintended pregnancies as a public health problem both globally and specifically in Nigeria as the authors demonstrated. Implementation efforts to increase utility of long-acting reversible contraception is being encouraged.</p>
            <p> 
                <bold>Abstract</bold>
            </p>
            <p> Several grammatical errors need to be addressed throughout the manuscript and abstract. Some examples include; 
                <list list-type="order">
                    <list-item>
                        <p>The main aim of this study is to identify the factors 
                            <bold>influencing the women</bold> associated with use of LARC and to examine the relationship between knowledge of LARC and its current use.</p>
                    </list-item>
                    <list-item>
                        <p>Findings further showed that at both levels of analyses there is a significant relationship (P&lt;0.05 and P=0.00 for binary and multivariable logistic regression, respectively) between knowledge of 
                            <bold>LARCs and uses in this study</bold>.</p>
                    </list-item>
                    <list-item>
                        <p>Also, the authors should minimize or avoid use of &#x201c;it&#x201d; and instead describe it as &#x201c;LARCs) as was described in the statement; &#x201c;This means that knowledge of LARC &amp; other socio-demographic variables among women of reproductive age in Nigeria can influence the use of 
                            <bold>it.</bold>&#x201d;</p>
                    </list-item>
                </list> &#x00a0;The authors should specify which &#x201c;other socio-demographics&#x201d; to describe in the abstract that are associated with LARC use.</p>
            <p> Revise they conclusion into a total of 2-3 sentences to include the implications of this study on practice, policy and/or research. The authors described the implications in the conclusion of the main manuscript and so should do the same in the abstract</p>
            <p> 
                <bold>Main manuscript/document</bold>
            </p>
            <p> 
                <bold>Introduction</bold>
            </p>
            <p> In the this section, include a citation for the sentence, &#x201c;Recently, the expansion in choice of contraceptives available has given women the option of adopting the use of Long-acting reversible contraceptives (LARCs) which are implant and intrauterine device contraceptive methods that are highly effective and convenient with an added advantage of being long-lasting,</p>
            <p> require little or no maintenance.</p>
            <p> 
                <bold>Results</bold>
            </p>
            <p> Table 2 is unusually brief with a single row of results. The authors should include the 14.8% prevalence of LARC users (frequency and 95%CI too in order to fit the columns titles already created)</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Yes</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Yes</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Yes</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Yes</p>
            <p>Reviewer Expertise:</p>
            <p>Reproductive health epidemiology, Global Health and mixed methods research</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
        <sub-article article-type="response" id="comment3318-28811">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Bolarinwa</surname>
                            <given-names>Obasanjo</given-names>
                        </name>
                        <aff>Obafemi Awolowo University, Nigeria</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>None</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>16</day>
                    <month>5</month>
                    <year>2020</year>
                </pub-date>
            </front-stub>
            <body>
                <p>Hello,</p>
                <p> </p>
                <p> Thanks for this awesome review, please find below my replies bolded.</p>
                <p> </p>
                <p> Abstract 
                    <list list-type="bullet">
                        <list-item>
                            <p>
                                <bold>Several grammatical errors need to be addressed throughout the manuscript and abstract. Some</bold>
                            </p>
                        </list-item>
                    </list> examples include; 
                    <list list-type="order">
                        <list-item>
                            <p>The main aim of this study is to identify the factors 
                                <bold>influencing the women</bold> associated with use of LARC and to examine the relationship between knowledge of LARC and its current use. - 
                                <bold>All grammatical error has been corrected.</bold>
                            </p>
                        </list-item>
                        <list-item>
                            <p>Findings further showed that at both levels of analyses there is a significant relationship (P&lt;0.05 and P=0.00 for binary and multivariable logistic regression, respectively) between knowledge of 
                                <bold>LARCs and uses in this study</bold>. - 
                                <bold>All grammatical error has been corrected.</bold>
                            </p>
                        </list-item>
                        <list-item>
                            <p>Also, the authors should minimize or avoid use of &#x201c;it&#x201d; and instead describe it as &#x201c;LARCs) as was described in the statement; &#x201c;This means that knowledge of LARC &amp; other socio-demographic variables among women of reproductive age in Nigeria can influence the use of it.&#x201d; &#x2013; 
                                <bold>All grammatical error has been corrected.</bold>
                            </p>
                        </list-item>
                    </list> The authors should specify which &#x201c;other socio-demographics&#x201d; to describe in the abstract that are associated with LARC use. &#x2013; 
                    <bold>All socio-demographic factors associated has been listed out, there are no &#x201c;other&#x201d; socio-demographic factors</bold>.</p>
                <p> Revise they conclusion into a total of 2-3 sentences to include the implications of this study on practice, policy and/or research. The authors described the implications in the conclusion of the main manuscript and so should do the same in the abstract. &#x2013; 
                    <bold>This has been included</bold>
                </p>
                <p> 
                    <bold>Main manuscript/document</bold>
                </p>
                <p> Introduction</p>
                <p> In the this section, include a citation for the sentence, &#x201c;Recently, the expansion in choice of contraceptives available has given women the option of adopting the use of Long-acting reversible contraceptives available has given women the option of adopting the use of Long-acting reversible contraceptives (LARCs) which are implant and intrauterine device contraceptive methods that are highly effective and convenient with an added advantage of being long-lasting, require little or no maintenance. 
                    <bold>&#x2013; The reference is the second on the reference list. &#x201c;
                        <italic>Stoddard A, McNicholas C, Peipert JF: Efficacy and safety of long-acting reversible contraception. Drugs. 2011;71(8):969&#x2013;980. 21668037 10.2165/11591290-000000000-00000 3662967</italic>&#x201d; All these references have been listed as 1-4 at the end of the first paragraph, citing &#x201c;2&#x201d; at the end of this sentence will distort the referencing style.</bold>
                </p>
                <p> Results</p>
                <p> Table 2 is unusually brief with a single row of results. The authors should include the 14.8% prevalence of LARC users (frequency and 95%CI too in order to fit the columns titles already created). &#x2013; 
                    <bold>This has been included.</bold>
                </p>
            </body>
        </sub-article>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report27839">
        <front-stub>
            <article-id pub-id-type="doi">10.21956/gatesopenres.13998.r27839</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Ajong</surname>
                        <given-names>Atem Bethel</given-names>
                    </name>
                    <xref ref-type="aff" rid="r27839a2">2</xref>
                    <xref ref-type="aff" rid="r27839a3">3</xref>
                    <xref ref-type="aff" rid="r27839a4">4</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-5513-2110</uri>
                </contrib>
                <contrib contrib-type="author">
                    <name>
                        <surname>Yakum</surname>
                        <given-names>Martin Ndinakie</given-names>
                    </name>
                    <xref ref-type="aff" rid="r27839a1">1</xref>
                    <role>Co-referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0003-3149-2020</uri>
                </contrib>
                <aff id="r27839a1">
                    <label>1</label>Medecins Sans Frontieres-Spain (MSF-OCBA), Maiduguri, Nigeria</aff>
                <aff id="r27839a2">
                    <label>2</label>Department of mother and child health, Kekem District Hospital, West Region, Cameroon</aff>
                <aff id="r27839a3">
                    <label>3</label>Department of Obstetrics and Gynaecology, Faculty of Medicine and Biomedical Sciences, University of Yaound&#x00e9; I, Yaound&#x00e9;, Cameroon</aff>
                <aff id="r27839a4">
                    <label>4</label>Department of Biochemistry, University of Dschang, West Region, Cameroon</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>30</day>
                <month>9</month>
                <year>2019</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2019 Yakum MN and Ajong AB</copyright-statement>
                <copyright-year>2019</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport27839" related-article-type="peer-reviewed-article" xlink:href="10.12688/gatesopenres.12902.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>The authors address contraceptive use; a very important pillar in reproductive health. They focus on long acting reversible contraception among current contraceptive users. As already stated by the authors, long acting reversible contraceptives (LARC) are associated with higher contraceptive efficacy (less than 1 % failure rates) and higher rates of contraceptive continuity. Its contribution in shifting the contraceptive method mix to an ideal position in every population is significant and therefore a knowledge of some factors that can influence their uptake is vital.</p>
            <p> </p>
            <p> The authors evaluate the knowledge of reproductive age women on LARCs and go further to identify some factors associated to LARC use. Globally the manuscript is well drafted with presented results responding only partially to the set objectives.</p>
            <p> </p>
            <p> One key word in the title of the paper is knowledge but it is unclear if actually the knowledge was evaluated. Having heard of something does not necessary mean you know about it. We must be a little careful; using something gives you the opportunity to know about it. We are of the belief that use can influence knowledge and knowledge can also influence use. For example, you cannot be using IUD and say that you have never heard of it. The key question is what did you know about it before deciding to use? Also, &#x201c;reproductive age&#x201d; features as a key word in the title when the study was carried out among contraceptive users. From these analyses, we think the title of the paper should be changed because of its misleading nature. &#x201c;Factors influencing adoption of LARCs among contraceptive users in Nigeria&#x201d; is a possible title.</p>
            <p> </p>
            <p> The write up still requires serious English editing and corrections for a scientific paper (it should probably be edited by a native English speaker). Further statistical analyses are indispensable. Our comments are presented below section wise.</p>
            <p> </p>
            <p> 
                <bold>Abstract</bold>
            </p>
            <p> Please correct the English thoroughly and make sure the tenses are adapted.</p>
            <p> </p>
            <p> The very first statement of the abstract is unclear and seems to contradict science unless my reading and understanding is not that of the authors. Reading the statement as it is gives a wrong understanding to the reader. One will think the authors are suggesting a global contraceptive failure rate of 48%. Or do the authors mean &#x201c;48% of unintended pregnancy that occur in contraceptive user is due to human error&#x201d;. Please totally rephrase to ease understanding. In addition the references used to state this rate down in your background (ref 5 and 6 are not adapted and have nothing to do with the declarations), please verify and correct.</p>
            <p> </p>
            <p> Please try to reformulate the objective of the study and in doing so replace the word &#x201c;examine&#x201d; which does not seem adapted for this purpose.</p>
            <p> </p>
            <p> In the method section, please try to include the survey type used to collect this data, include the threshold of significance of the p-value for the identification of the different factors associated with LARCs.</p>
            <p> </p>
            <p> In the result section, one will want to see at least the mean age and the marital status of the considered population. In addition, you start by presenting the rate of use of traditional methods of contraception which responds to no set objective.</p>
            <p> </p>
            <p> Major findings like the rate of use of LARCs should be presented with their 95% Confidence intervals.</p>
            <p> </p>
            <p> Still in your results, you state &#x201c;findings further revealed&#x2026;&#x201d; please avoid using this word revealed.</p>
            <p> </p>
            <p> Concerning your conclusions, you state &#x201c;This study concludes&#x2026;.&#x201d; Please reformulate. You are the one concluding from the results of the study, not the study concluding. In addition, there is serious discordance between your results presented on the abstract and the conclusions. According to your results, LARC use is influenced by the level of knowledge of the women on LARCs but in your conclusion, you state that LARC use is affected by level of education, age of women, &#x2026;after controlling for confounders which we don&#x2019;t know yet. Please correct accordingly</p>
            <p> </p>
            <p> 
                <bold>Introduction</bold>
            </p>
            <p> Please edit and strengthen the English in this section.</p>
            <p> </p>
            <p> Please reformulate the first sentence of paragraph one. It is not the rising use of contraception that is giving women the ability to choose, but the fact that modern contraception is becoming more and more available and accessible cost to the population.</p>
            <p> </p>
            <p> Paragraph 2. The authors state &#x201c;Also LARC methods have the ability to bridge the gap between &#x201c;typical use&#x201d; and perfect use&#x201d; failure rates&#x201d; Does the use of LARCs reduce or bridge the gap? The word bridge is confusing and makes the reader to wonder on the really message the authors wish to pass out here. Most importantly, the sentence just after the above mentioned sentence (the rest of the whole paragraph) should be reformulated and adequately referenced.</p>
            <p> </p>
            <p> Paragraph 4. The authors state &#x201c;despite the level of awareness...&#x201d;. I wish to remind the authors that the presented awareness rates of the IUD and implants are already low.</p>
            <p> </p>
            <p> Some background information is lacking. What was the rate of LARC use in Nigeria according the NDHS data? What are some factors that have been identified in Nigeria, and sub-Saharan African or in Africa as a whole to influence the use of LARCs? What about the availability and accessibility of these methods in the study populations? Are they available and trained providers to administer these methods? Please complete this information because it might help understand your findings.</p>
            <p> </p>
            <p> Your last paragraph should be totally reformulated and made clearer.</p>
            <p> </p>
            <p> 
                <bold>Methods</bold>
            </p>
            <p> Is there a possibility to cite the methodology used? If yes, it will be better to cite the protocol if it was published.</p>
            <p> </p>
            <p> What do the authors mean by a weighted sample size? Why a weighted sample size? Detailed information on how the weighted sample size was obtained is indispensable.</p>
            <p> </p>
            <p> The authors should provide a definition for a current contraceptive user in this study. Because this definition affects the contraceptive method mix. For instance, a condom user who did not engage in sexual activity for a month before the study and therefore did not use a condom; where was she placed? Please a precise definition for a current user is needed.</p>
            <p> </p>
            <p> The data analysis section is too scanty and difficult to follow. Binary logistic regression generates ORs which are adjusted (AOR) following multiple logistic regression
                <sup>
                    <xref ref-type="bibr" rid="rep-ref-27839-1">1</xref>
                </sup>. What was the threshold of significance for both level of analyses. What criteria did you use to include variables in the multiple logistic regression model? What were the confounders you mentioned in your abstract? What criteria did you used to consider a variable a confounder? Please be more explicit
                <sup>
                    <xref ref-type="bibr" rid="rep-ref-27839-2">2</xref>
                </sup>.</p>
            <p> </p>
            <p> In addition, as already stated above, analysis of the association of knowledge and use of LARCs is meaningless when the element of knowledge is just &#x201c;have heard of it&#x201d;. What do we expect? To say that some women are using and have not heard of it? We really need to know what they know about each method or LARCs as a whole and it will be ideal to try to rather know what they knew about it before initiation of use. Also, the sources of information on the LARCs are good but we have to also know &#x201c;when&#x201d;. For example, if you start using something, you can want to know more about it and when you know more by reading through the newspaper, the information you get can rather affect adherence or discontinuation.</p>
            <p> 
                <bold>Results</bold>
            </p>
            <p> Please replace &#x201c;women currently using any method of contraception or family planning&#x201d; with women currently using contraception all through your text.</p>
            <p> </p>
            <p> Please reformulate the sentence presenting the level of education of the participants in paragraph 1. One has the impression that those who are considered in higher education are from the proportion in secondary education, of which it is not the case.</p>
            <p> </p>
            <p> Please what definition do you give to married here? Do you include only legally married or in this group we have women in consensual unions? Please be precise.</p>
            <p> </p>
            <p> I think if data on the full contraceptive method mix was available and presented here, it would make this a better manuscript. Please present this data before you focus on LARCs. In the proportion considered to be using LARCs, why was precise data on the IUCD and the implant not included? In addition add a 95% CI to the LARC rate.</p>
            <p> </p>
            <p> Paragraph 5 from Table 5. Please include how knowledge affects use of LARCs; that is, the direction of association. The last sentence of this paragraph declaring that use of LARCs sole depends on knowledge should be taken off. If this is even true then there is no essence of testing for the other factors presented below. Or are the authors suggesting that all the other factors I see below are confounders?</p>
            <p> </p>
            <p> The factors presented in this paper were evaluated by simple logistic regression with no confounders defined. The level of education of the participants can affect their wealth index, their number of children, family planning discussion and their likelihood to visit a health worker. Each of the considered factors should logically be controlled for other possible factors. Without this, this section is of no significant importance to the write-up.</p>
            <p> </p>
            <p> 
                <bold>Discussion</bold>
            </p>
            <p> The whole discussion section has to be retaken. It seems more like a repetition of already presented results than analytically putting findings into context. Please do correct this section.</p>
            <p> </p>
            <p> 
                <bold>Limitations</bold>
            </p>
            <p> Major limitations associated to this study have not been addressed. Method and design liked limitations have totally been left out. The cross sectional design used to collect the data comes with major limitations allowing us with mere hypotheses than real cause effect relationships. In addition, associations might just have been temporary.</p>
            <p> </p>
            <p> 
                <bold>Future suggestions</bold>
            </p>
            <p> Your first two sentences are a repetition. Please correct.</p>
            <p> </p>
            <p> 
                <bold>Conclusions</bold>
            </p>
            <p> The very first sentence of the conclusion has a problem. Please read carefully and correct.</p>
            <p> The second sentence is not correct. No confounders were controlled in the statistical analysis. All the presented factors need to be reviewed after reanalysis.</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Partly</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Partly</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Partly</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Reviewer Expertise:</p>
            <p>Reproductive Health, Public Health and Epidemiology, Clinical Medicine, Clinical Biochemistry.</p>
            <p>We confirm that we have read this submission and believe that we have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however we have significant reservations, as outlined above.</p>
        </body>
        <back>
            <ref-list>
                <title>References</title>
                <ref id="rep-ref-27839-1">
                    <label>1</label>
                    <mixed-citation publication-type="journal">
                        <person-group person-group-type="author"/>:
                        <article-title>Model building strategy for logistic regression: purposeful selection.</article-title>
                        <source>
                            <italic>Ann Transl Med</italic>
                        </source>.<year>2016</year>;<volume>4</volume>(<issue>6</issue>) :
                        <elocation-id>10.21037/atm.2016.02.15</elocation-id>
                        <fpage>111</fpage>
                        <pub-id pub-id-type="pmid">27127764</pub-id>
                        <pub-id pub-id-type="doi">10.21037/atm.2016.02.15</pub-id>
                    </mixed-citation>
                </ref>
                <ref id="rep-ref-27839-2">
                    <label>2</label>
                    <mixed-citation publication-type="journal">
                        <person-group person-group-type="author"/>:
                        <article-title>Controlling for continuous confounders in epidemiologic research.</article-title>
                        <source>
                            <italic>Epidemiology</italic>
                        </source>.<year>1997</year>;<volume>8</volume>(<issue>4</issue>) :<fpage>429</fpage>-<lpage>34</lpage>
                        <pub-id pub-id-type="pmid">9209859</pub-id>
                    </mixed-citation>
                </ref>
            </ref-list>
        </back>
        <sub-article article-type="response" id="comment3308-27839">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Bolarinwa</surname>
                            <given-names>Obasanjo</given-names>
                        </name>
                        <aff>Obafemi Awolowo University, Nigeria</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>None</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>9</day>
                    <month>4</month>
                    <year>2020</year>
                </pub-date>
            </front-stub>
            <body>
                <p>Reply to comments</p>
                <p> The authors evaluate the knowledge of reproductive age women on LARCs and go further to identify some factors associated to LARC use. Globally the manuscript is well drafted with &#x201c;presented results responding only partially to the set objectives.&#x201d;</p>
                <p> &#x00a0; 
                    <list list-type="order">
                        <list-item>
                            <p>&#x201c;One key word in the title of the paper is knowledge but it is unclear if the knowledge was Evaluated&#x201d;- 
                                <bold>We used ever &#x201c;HEARD&#x201d; as a proxy to Knowledge</bold>
                            </p>
                        </list-item>
                    </list> &#x00a0; 
                    <list list-type="order">
                        <list-item>
                            <p>Abstract &#x2013; &#x201c;The very first statement of the abstract is unclear and seems to contradict science unless my reading and understanding is not that of the authors. Reading the statement as it is gives a wrong understanding to the reader. One will think the authors are suggesting a global contraceptive failure rate of 48%. Or do the authors mean &#x201c;48% of unintended pregnancy that occur in contraceptive user is due to human error&#x201d;. Please totally rephrase to ease understanding. In addition the references used to state this rate down in your background (ref 5 and 6 are not adapted and have nothing to do with the declarations), please verify and correct&#x201d;. Accepted
                                <bold> &#x2013; Abstract &amp; Intro &#x2013; Reference added.</bold>
                            </p>
                        </list-item>
                    </list> &#x00a0; 
                    <list list-type="order">
                        <list-item>
                            <p>&#x201c;Please try to reformulate the objective of the study and in doing so replace the word &#x201c;examine&#x201d; which does not seem adapted for this purpose&#x201d;. 
                                <bold>Accepted &#x2013; Changed the word examine in the objective to identify and re-arranged.</bold>
                            </p>
                        </list-item>
                    </list> &#x00a0; 
                    <list list-type="order">
                        <list-item>
                            <p>&#x201c;In the method section, please try to include the survey type used to collect this data, include the threshold of significance of the p-value for the identification of the different factors associated with LARCs&#x201d; .
                                <bold>Accepted- In the method section survey type included.</bold>
                            </p>
                        </list-item>
                    </list> &#x00a0; 
                    <list list-type="order">
                        <list-item>
                            <p>&#x201c;In the result section, one will want to see at least the mean age and the marital status of the considered population. In addition, you start by presenting the rate of use of traditional methods of contraception which responds to no set objective. &#x2013; 
                                <bold>Table 1 presented the mean age and marital status</bold>
                            </p>
                        </list-item>
                    </list> &#x00a0; 
                    <list list-type="order">
                        <list-item>
                            <p>Major findings like the rate of use of LARCs should be presented with their 95% Confidence intervals. &#x2013; 
                                <bold>Done</bold>
                            </p>
                        </list-item>
                    </list> 
                    <bold>Use of LARC with their 95% Confidence intervals. </bold>
                </p>
                <p> 
                    <bold>Variable </bold>&#x200b;&#x200b;&#x200b;&#x200b;&#x200b;&#x200b;
                    <bold>Std. Err.</bold>
                    <bold>95% CI</bold>
                </p>
                <p>
                    <bold> &#x200b;&#x200b;&#x200b;&#x200b;&#x200b;&#x200b;&#x200b;</bold>
                </p>
                <p> LARC use &#x200b;&#x200b;&#x200b;0.1320 &#x2013; 0.1638 
                    <list list-type="order">
                        <list-item>
                            <p>&#x201c;Still in your results, you state &#x201c;findings further revealed&#x2026;&#x201d; please avoid using this word revealed. &#x2013; 
                                <bold>Acknowledged.</bold>
                            </p>
                        </list-item>
                    </list> &#x00a0; 
                    <list list-type="order">
                        <list-item>
                            <p>&#x201c;Concerning your conclusions, you state &#x201c;This study concludes&#x2026;.&#x201d; Please reformulate. You are the one concluding from the results of the study, not the study concluding. In addition, there is serious discordance between your results presented on the abstract and the conclusions. According to your results, LARC use is influenced by the level of knowledge of the women on LARCs but in your conclusion, you state that LARC use is affected by level of education, age of women, &#x2026;after controlling for confounders which we don&#x2019;t know yet. Please correct accordingly&#x201d; &#x2013; 
                                <bold>Corrected </bold>
                            </p>
                        </list-item>
                    </list> &#x00a0; 
                    <list list-type="order">
                        <list-item>
                            <p>Introduction - Please edit and strengthen the English in this section. - 
                                <bold>Acknowledged.</bold>
                            </p>
                        </list-item>
                    </list> &#x00a0; 
                    <list list-type="order">
                        <list-item>
                            <p>Please reformulate the first sentence of paragraph one. It is not the rising use of contraception that is giving women the ability to choose, but the fact that modern contraception is becoming more and more available and accessible cost to the population. - 
                                <bold>Acknowledged.</bold>
                            </p>
                        </list-item>
                    </list> &#x00a0; 
                    <list list-type="order">
                        <list-item>
                            <p>Paragraph 2. The authors state &#x201c;Also LARC methods have the ability to bridge the gap between &#x201c;typical use&#x201d; and perfect use&#x201d; failure rates&#x201d; Does the use of LARCs reduce or bridge the gap? The word bridge is confusing and makes the reader to wonder on the really message the authors wish to pass out here. Most importantly, the sentence just after the above mentioned sentence (the rest of the whole paragraph) should be reformulated and adequately referenced. - 
                                <bold>Acknowledged.</bold>
                            </p>
                        </list-item>
                    </list> &#x00a0; 
                    <list list-type="order">
                        <list-item>
                            <p>Paragraph 4. The authors state &#x201c;despite the level of awareness...&#x201d;. I wish to remind the authors that the presented awareness rates of the IUD and implants are already low. - 
                                <bold>Acknowledged.</bold>
                            </p>
                        </list-item>
                    </list> &#x00a0; 
                    <list list-type="order">
                        <list-item>
                            <p>Some background information is lacking. What was the rate of LARC use in Nigeria according the NDHS data? What are some factors that have been identified in Nigeria, and sub-Saharan African or in Africa as a whole to influence the use of LARCs? What about the availability and accessibility of these methods in the study populations? Are they available and trained providers to administer these methods? Please complete this information because it might help understand your findings. - 
                                <bold>Acknowledged.</bold>
                            </p>
                        </list-item>
                    </list> &#x00a0; 
                    <list list-type="order">
                        <list-item>
                            <p>Your last paragraph should be totally reformulated and made clearer.-
                                <bold> Acknowledged.</bold>
                            </p>
                        </list-item>
                    </list> &#x00a0; 
                    <list list-type="order">
                        <list-item>
                            <p>Methods - Is there a possibility to cite the methodology used? If yes, it will be better to cite the protocol if it was published.- 
                                <bold>Done</bold>
                            </p>
                        </list-item>
                    </list> &#x00a0; 
                    <list list-type="order">
                        <list-item>
                            <p>What do the authors mean by a weighted sample size? Why a weighted sample size? Detailed information on how the weighted sample size was obtained is indispensable. &#x2013; 
                                <bold>Acknowledged and corrected</bold>
                            </p>
                        </list-item>
                    </list> &#x00a0; 
                    <list list-type="order">
                        <list-item>
                            <p>The authors should provide a definition for a current contraceptive user in this study. Because this definition affects the contraceptive method mix. For instance, a condom user who did not engage in sexual activity for a month before the study and therefore did not use a condom; where was she placed? Please a precise definition for a current user is needed. 
                                <bold>&#x2013; Done</bold>
                            </p>
                        </list-item>
                    </list> &#x00a0;</p>
                <p> 
                    <bold>women ages 15&#x2013;49 who are using (or whose partners are using) any contraceptive method at the time of the survey</bold>
                </p>
                <p> &#x00a0; 
                    <list list-type="order">
                        <list-item>
                            <p>The data analysis section is too scanty and difficult to follow. Binary logistic regression generates ORs which are adjusted (AOR) following multiple logistic regression . What was the threshold of significance for both level of analyses. What criteria did you use to include variables in the multiple logistic regression model? What were the confounders you mentioned in your abstract? What criteria did you used to consider a variable a confounder? Please be more explicit .In addition, as already stated above, analysis of the association of knowledge and use of LARCs is meaningless when the element of knowledge is just &#x201c;have heard of it&#x201d;. What do we expect? To say that some women are using and have not heard of it? We really need to know what they know about each method or LARCs as a whole and it will be ideal to try to rather know what they knew about it before initiation of use. Also, the sources of information on the LARCs are good but we have to also know&#x201c;when&#x201d;. For example, if you start using something, you can want to know more about it and when you</p>
                        </list-item>
                    </list> know more by reading through the newspaper, the information you get can rather affect adherence or discontinuation. &#x2013; 
                    <bold>Done</bold>
                </p>
                <p> 
                    <bold>The variable were added to logistic regression based on literature review and association at chi-square level. Knowledge of LARC and Use of LARC has been analyzed (Check Table 5 )</bold>
                </p>
                <p> &#x00a0; 
                    <list list-type="order">
                        <list-item>
                            <p>Results - Please replace &#x201c;women currently using any method of contraception or family planning&#x201d; with women currently using contraception all through your text. - 
                                <bold>Acknowledged.</bold>
                            </p>
                        </list-item>
                    </list> &#x00a0; 
                    <list list-type="order">
                        <list-item>
                            <p>Please reformulate the sentence presenting the level of education of the participants in paragraph 1. One has the impression that those who are considered in higher education are from the proportion in secondary education, of which it is not the case.- 
                                <bold>Done </bold>
                            </p>
                        </list-item>
                    </list> &#x00a0;</p>
                <p> &#x00a0; 
                    <list list-type="order">
                        <list-item>
                            <p>Please what definition do you give to married here? Do you include only legally married or in this group we have women in consensual unions? Please be precise. I think if data on the full contraceptive method mix was available and presented here, it would make this a better manuscript. Please present this data before you focus on LARCs. In the proportion considered to be using LARCs, why was precise data on the IUCD and the implant not included? In addition add a 95% CI to the LARC rate.- 
                                <bold>&#x00a0;Done </bold>
                            </p>
                        </list-item>
                    </list> &#x00a0;</p>
                <p> Method Mix of current user</p>
                <p> </p>
                <p> 
                    <bold>Married includes married women and those who are living with a man</bold>
                </p>
                <p> &#x00a0; 
                    <list list-type="order">
                        <list-item>
                            <p>Paragraph 5 from Table 5. Please include how knowledge affects use of LARCs; that is, the direction of association. The last sentence of this paragraph declaring that use of LARCs sole depends on knowledge should be taken off. If this is even true then there is no essence of testing for the other factors presented below. Or are the authors suggesting that all the other factors I see below are confounders?- 
                                <bold>Done</bold>
                            </p>
                        </list-item>
                    </list> &#x00a0; 
                    <list list-type="order">
                        <list-item>
                            <p>The factors presented in this paper were evaluated by simple logistic regression with no confounders defined. The level of education of the participants can affect their wealth index, their number of children, family planning discussion and their likelihood to visit a health worker. Each of the considered factors should logically be controlled for other possible factors. Without this, this section is of no significant importance to the write-up. - 
                                <bold>Corrected</bold>
                            </p>
                        </list-item>
                    </list> &#x00a0; 
                    <list list-type="order">
                        <list-item>
                            <p>Discussion - The whole discussion section has to be retaken. It seems more like a repetition of already presented results than analytically putting findings into context. Please do correct this section. -
                                <bold> Corrected</bold>
                            </p>
                        </list-item>
                    </list> &#x00a0; 
                    <list list-type="order">
                        <list-item>
                            <p>Limitations - Major limitations associated to this study have not been addressed. Method and design liked limitations have totally been left out. The cross sectional design used to collect the data comes with major limitations allowing us with mere hypotheses than real cause effect relationships. In addition, associations might just have been temporary. 
                                <bold>Done</bold>
                            </p>
                        </list-item>
                    </list> &#x00a0; 
                    <list list-type="order">
                        <list-item>
                            <p>Future suggestions - Your first two sentences are a repetition. Please correct. 
                                <bold>Corrected</bold>
                            </p>
                        </list-item>
                    </list> &#x00a0; 
                    <list list-type="order">
                        <list-item>
                            <p>Conclusions - The very first sentence of the conclusion has a problem. Please read carefully and correct. The second sentence is not correct. No confounders were controlled in the statistical analysis. All the presented factors need to be reviewed after reanalysis. 
                                <bold>Done</bold>
                            </p>
                        </list-item>
                    </list>
                </p>
            </body>
        </sub-article>
    </sub-article>
</article>
