<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2 20190208//EN" "http://jats.nlm.nih.gov/publishing/1.2/JATS-journalpublishing1.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="research-article" dtd-version="1.2" xml:lang="en">
    <front>
        <journal-meta>
            <journal-id journal-id-type="pmc">Gates Open Res</journal-id>
            <journal-title-group>
                <journal-title>Gates Open Research</journal-title>
            </journal-title-group>
            <issn pub-type="epub">2572-4754</issn>
            <publisher>
                <publisher-name>F1000 Research Limited</publisher-name>
                <publisher-loc>London, UK</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="doi">10.12688/gatesopenres.12928.1</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Research Article</subject>
                </subj-group>
                <subj-group>
                    <subject>Articles</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>How many child deaths can be averted in Nigeria? Assessing state-level prospects of achieving 2030 sustainable development goals for neonatal and under-five mortality</article-title>
                <fn-group content-type="pub-status">
                    <fn>
                        <p>[version 1; peer review: 1 approved, 2 approved with reservations]</p>
                    </fn>
                </fn-group>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author" corresp="yes">
                    <name>
                        <surname>Ogbuoji</surname>
                        <given-names>Osondu</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0003-2472-6861</uri>
                    <xref ref-type="corresp" rid="c1">a</xref>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Yamey</surname>
                        <given-names>Gavin</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-8390-7382</uri>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <aff id="a1">
                    <label>1</label>Center for Policy Impact in Global Health, Duke University, Durham, NC, 27710, USA</aff>
            </contrib-group>
            <author-notes>
                <corresp id="c1">
                    <label>a</label>
                    <email xlink:href="mailto:osondu.ogbuoji@duke.edu">osondu.ogbuoji@duke.edu</email>
                </corresp>
                <fn fn-type="conflict">
                    <p>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>9</day>
                <month>5</month>
                <year>2019</year>
            </pub-date>
            <pub-date pub-type="collection">
                <year>2019</year>
            </pub-date>
            <volume>3</volume>
            <elocation-id>1460</elocation-id>
            <history>
                <date date-type="accepted">
                    <day>24</day>
                    <month>4</month>
                    <year>2019</year>
                </date>
            </history>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2019 Ogbuoji O and Yamey G</copyright-statement>
                <copyright-year>2019</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <self-uri content-type="pdf" xlink:href="https://gatesopenresearch.org/articles/3-1460/pdf"/>
            <abstract>
                <p>
                    <bold>Background:</bold> Nigeria&#x2019;s neonatal mortality rate (NMR) and under-five mortality rate (U5MR) are 39 per 1,000 and 120 per 1,000 live births, respectively On average, 0.23 million neonates and 0.7 million under-five children die every year, but some states contribute more to this burden than others. If the country is to meet its sustainable development goal (SDG) targets for NMR and U5MR, it would need to make progress at both the national and subnational levels.</p>
                <p>
                    <bold>Methods:</bold> Using the 2016&#x2013;2017 Nigeria Multiple Indicator Cluster Survey (MICS), we estimated state-level neonatal and under-five mortality rates. Next, we estimated how long it would take for each state to reach the SDG targets for NMR and U5MR. Finally, we estimated the average number of neonatal and under-five deaths that could be averted between 2018 and 2030 in each state under different scenarios.</p>
                <p>
                    <bold>Results:</bold> At current average annual rates of decline, Nigeria is unlikely to meet both sustainable development goals targets for NMR and U5MR. At the subnational level, some states are close to or have met both NMR and U5MR targets, while others are projected to meet the targets as late as 2088 (58 years delayed). Between 850,000 and 1.89 million neonatal deaths could be averted between 2018 and 2030, while 3.1 million to 5.96 million under-five deaths could be averted over the same period.</p>
                <p>
                    <bold>Conclusions:</bold> Nigeria has the potential to achieve its SDG targets for NMR and U5MR, and in the process avert millions of preventable child deaths. But this will not happen under a business-as-usual approach. The NMR and U5MR trajectories achieved by high-performing states is evidence that achieving these SDG targets is possible. For the country to achieve positive results nationally, systems that encourage peer learning and transfer of technical expertise between states are needed.</p>
            </abstract>
            <kwd-group kwd-group-type="author">
                <kwd>neonatal mortality</kwd>
                <kwd>under-five mortality</kwd>
                <kwd>sustainable development goals</kwd>
                <kwd>Nigeria</kwd>
                <kwd>sub-Saharan Africa</kwd>
            </kwd-group>
            <funding-group>
                <award-group id="fund-1" xlink:href="http://www.gatesfoundation.org">
                    <funding-source>Gates Foundation</funding-source>
                    <award-id>OPP1151682</award-id>
                </award-group>
                <funding-statement>This work was supported by the Gates Foundation [OPP1151682].</funding-statement>
                <funding-statement>
                    <italic>The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</italic>
                </funding-statement>
            </funding-group>
        </article-meta>
    </front>
    <body>
        <sec sec-type="intro">
            <title>Introduction</title>
            <p>In spite of the progress achieved over the past few decades, Nigeria still has very poor child survival metrics
                <sup>
                    <xref ref-type="bibr" rid="ref-1">1</xref>,
                    <xref ref-type="bibr" rid="ref-2">2</xref>
                </sup>. With an under-five mortality rate (U5MR) of 104 per 1,000 live births, and a neonatal mortality rate (NMR) of 34 per 1,000 live births in 2017, the country ranks 6
                <sup>th</sup> highest in the world for child mortality, and the highest of all middle-income countries
                <sup>
                    <xref ref-type="bibr" rid="ref-3">3</xref>,
                    <xref ref-type="bibr" rid="ref-4">4</xref>
                </sup>. It also ranks in the top 10 countries with the highest number of under-five deaths annually
                <sup>
                    <xref ref-type="bibr" rid="ref-5">5</xref>
                </sup>.</p>
            <p>Recent estimates suggest that on average about 0.7 million children under the age of five die every year in Nigeria, with about 200,000 of these children dying in the first month of life
                <sup>
                    <xref ref-type="bibr" rid="ref-4">4</xref>,
                    <xref ref-type="bibr" rid="ref-6">6</xref>
                </sup>. With such a high number of annual neonatal deaths, the country accounted for about 9% of all neonatal deaths in the world in 2016
                <sup>
                    <xref ref-type="bibr" rid="ref-7">7</xref>
                </sup>. Nigeria and India both account for one-third of all deaths due to lower respiratory infections worldwide; such infections disproportionately affect children under five years
                <sup>
                    <xref ref-type="bibr" rid="ref-8">8</xref>
                </sup>.</p>
            <p>In its bid to meet the child mortality target set for the millennium development goals (MDGs), i.e. a two-thirds reduction in the U5MR from 1990 to 2015, Nigeria made significant progress on child mortality. The country reduced the national average U5MR from 213 per 1,000 live births in 1990 to 104 per 1,000 live births in 2015. However, this reduction was not sufficient to meet its MDG under-five mortality 
                <ext-link ext-link-type="uri" xlink:href="http://www.ng.undp.org/content/nigeria/en/home/library/mdg/NigeriaMDGsSurveyReport2015.html">target</ext-link> of below 67 per 1,000 live births. Along with other United Nations member states, Nigeria has committed to achieving the 2030 sustainable development goals (SDGs). 
                <ext-link ext-link-type="uri" xlink:href="https://www.who.int/sdg/targets/en/">Target 3.2 of SDG3</ext-link> calls for all countries to reduce their U5MR to less than 25 deaths per 1,000 live births by 2030, and their NMR to less than 12 deaths per 1,000 live births by 2030.</p>
            <p>Given that Nigeria failed to meet its MDG target on U5MR, early tracking of its progress towards the health-related SDG targets is important&#x2014;if the country is off track, this would highlight the need for intensified action to accelerate progress. However, while there are already efforts to assess Nigeria&#x2019;s progress at the country level (e.g., national child mortality is tracked by 
                <ext-link ext-link-type="uri" xlink:href="http://www.childmortality.org/">The UN Inter-agency Group for Child Mortality Estimation</ext-link>), there are three key reasons why it is also critical to assess progress at the subnational level. First, according to 
                <ext-link ext-link-type="uri" xlink:href="https://nigerianstat.gov.ng/resource/POPULATION%20PROJECTION%20Nigeria%20sgfn.xls">latest estimates</ext-link> from the Nigeria Population Commission, the average population of a state in Nigeria is 5.5 million (range: 2.2 million to 13 million), exceeding the population of many countries. Second, there is a large variation in child and neonatal mortality across states in Nigeria (see 
                <xref ref-type="fig" rid="f1">Figure 1</xref>). For NMR, the rate ranges from 21 per 1,000 live births in Adamawa and Akwa-Ibom states to 69 per 1,000 live births in Kano state (the national average is 39 per 1,000 live births). For U5MR, the rate ranges from 45 per 1,000 live births in Kwara state to 210 per 1,000 live births in Zamfara state (the national average is 120 per 1,000)
                <sup>
                    <xref ref-type="bibr" rid="ref-9">9</xref>
                </sup>. An assessment of progress at the state level provides an opportunity to explore these variations in levels and trends. Third, subnational governments (state and local governments) are primarily responsible for healthcare delivery in Nigeria. Therefore, assessing progress at this subnational level has the advantage of providing information that would be useful to policy makers, promote evidence-based decision making, and improve levels of accountability.</p>
            <fig fig-type="figure" id="f1" orientation="portrait" position="float">
                <label>Figure 1. </label>
                <caption>
                    <title>State-level variations in neonatal mortality rates and under-five mortality rates.</title>
                    <p>Source: Authors calculations using MICS 2016&#x2013;17 data. Maps created with mapchart.net.</p>
                </caption>
                <graphic orientation="portrait" position="float" xlink:href="https://gatesopenresearch-files.f1000.com/manuscripts/14030/46d60af9-208e-44c4-85bc-d98523c0495a_figure1.gif"/>
            </fig>
            <p>In this study, we take advantage of the recently released 2016&#x2013;2017 Nigeria Multiple Indicator Cluster Survey (MICS) dataset, which for the first time allows state-level estimation of the NMR (SDG 3.2.1) and U5MR (SDG 3.2.2). Nigeria&#x2019;s MICS is a household survey conducted every five years to assess the health and social protection status of mothers and children around the country. Based on historical trends, we make projections of the feasibility of each state, and of the entire country, attaining the SDG targets for neonatal and under-five mortality by 2030. We also report on the number of child deaths that could potentially be averted under four different scenarios between 2018 and 2030, namely: 1) keeping 2017 mortality rates constant until 2030, 2) allowing mortality rates to change at current trends, 3) allowing mortality rates to decrease at best recorded sub-national rates of decline, and 4) allowing mortality rates to decrease at the rates of decline required to reach SDG targets by 2030.</p>
        </sec>
        <sec sec-type="methods">
            <title>Methods</title>
            <p>Our analysis involved three major steps. First, we estimated neonatal and under-five mortality rates for each state and for the country. Second, we estimated how long it would take for each state to reach the SDG targets for neonatal and under-five mortality rates. Finally, we estimated the average number of neonatal and under-five deaths that could be averted between 2018 and 2030 in each state under different scenarios.</p>
            <sec>
                <title>i) Estimating neonatal and under-five mortality rates</title>
                <p>To estimate state-level neonatal and under-five mortality rates, we analyzed data from the MICS conducted in Nigeria from 2016 to 2017. MICS have been conducted in Nigeria since 1995 by the Nigeria National Bureau of Statistics in concert with the United Nations International Children&#x2019;s Emergency Fund (UNICEF). These surveys track important indicators of health and social welfare for children, mothers, and their families. Prior to the 2016&#x2013;17 MICS, previous MICS had estimated child mortality through indirect methods and by using partial birth histories obtained from mothers. The 2016&#x2013;17 MICS was the first to obtain full birth histories from mothers that would enable more reliable estimates of child mortality using direct estimation methods. Households included in the survey were selected through a multi-stage stratified random sampling. Full birth history information was obtained for every woman present in the sampled household. Details of the 
                    <ext-link ext-link-type="uri" xlink:href="http://mics.unicef.org/tools?round=mics6">survey design and data collection methods</ext-link> have been described by the UNICEF MICS team.</p>
                <p>We estimated both neonatal and under-five mortality rates using the full birth histories contained in the 2016&#x2013;17 MICS datasets. We defined NMR as the probability of a newborn dying in the first 28 days of life, expressed per 1,000 live births, and U5MR as the probability of a child dying before reaching age 5 years, also expressed per 1,000 live births. See 
                    <xref ref-type="table" rid="T1">Table 1</xref> for details of our NMR and U5MR calculations.</p>
                <table-wrap id="T1" orientation="portrait" position="anchor">
                    <label>Table 1. </label>
                    <caption>
                        <title>Equations used for estimates in the study.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1"/>
                                <th align="left" colspan="1" rowspan="1">Estimate</th>
                                <th align="left" colspan="1" rowspan="1">Equation</th>
                                <th align="left" colspan="1" rowspan="1">Notes</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">1</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Average annual
                                    <break/>rates of change
                                    <break/>(AARC)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <disp-formula>
                                        <mml:math display="block" id="math1">
                                            <mml:mrow>
                                                <mml:mi>A</mml:mi>
                                                <mml:mi>A</mml:mi>
                                                <mml:mi>R</mml:mi>
                                                <mml:mi>C</mml:mi>
                                                <mml:mo>=</mml:mo>
                                                <mml:mfrac>
                                                    <mml:mrow>
                                                        <mml:mi>L</mml:mi>
                                                        <mml:mi>n</mml:mi>
                                                        <mml:mrow>
                                                            <mml:mo>(</mml:mo>
                                                            <mml:mrow>
                                                                <mml:mfrac>
                                                                    <mml:mrow>
                                                                        <mml:mi>M</mml:mi>
                                                                        <mml:msub>
                                                                            <mml:mi>R</mml:mi>
                                                                            <mml:mn>1</mml:mn>
                                                                        </mml:msub>
                                                                    </mml:mrow>
                                                                    <mml:mrow>
                                                                        <mml:mi>M</mml:mi>
                                                                        <mml:msub>
                                                                            <mml:mi>R</mml:mi>
                                                                            <mml:mn>0</mml:mn>
                                                                        </mml:msub>
                                                                    </mml:mrow>
                                                                </mml:mfrac>
                                                            </mml:mrow>
                                                            <mml:mo>)</mml:mo>
                                                        </mml:mrow>
                                                    </mml:mrow>
                                                    <mml:mrow>
                                                        <mml:msub>
                                                            <mml:mi>t</mml:mi>
                                                            <mml:mn>1</mml:mn>
                                                        </mml:msub>
                                                        <mml:mo>&#x2212;</mml:mo>
                                                        <mml:msub>
                                                            <mml:mi>t</mml:mi>
                                                            <mml:mn>0</mml:mn>
                                                        </mml:msub>
                                                    </mml:mrow>
                                                </mml:mfrac>
                                            </mml:mrow>
                                        </mml:math>
                                    </disp-formula>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">

                                    <italic toggle="yes">MR</italic>
                                    <sub>0</sub> is the mortality rate at the start year, 
                                    <italic toggle="yes">MR</italic>
                                    <sub>1</sub> is the
                                    <break/>mortality rate at the end year, AARC is the average annual
                                    <break/>rate of change (positive for increasing mortality rate, and
                                    <break/>negative for decreasing mortality rate), 
                                    <italic toggle="yes">t</italic>
                                    <sub>0</sub> is the start year,
                                    <break/>and 
                                    <italic toggle="yes">t</italic>
                                    <sub>1</sub> is the end year.</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">2</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Annual number of
                                    <break/>births</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <disp-formula>
                                        <mml:math display="block" id="math2">
                                            <mml:mrow>
                                                <mml:mi>B</mml:mi>
                                                <mml:mi>i</mml:mi>
                                                <mml:mi>r</mml:mi>
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                                                </mml:msub>
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                                                <mml:mi>P</mml:mi>
                                                <mml:mi>o</mml:mi>
                                                <mml:mi>p</mml:mi>
                                                <mml:mi>u</mml:mi>
                                                <mml:mi>l</mml:mi>
                                                <mml:mi>a</mml:mi>
                                                <mml:mi>t</mml:mi>
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                                                <mml:mi>B</mml:mi>
                                                <mml:mi>R</mml:mi>
                                            </mml:mrow>
                                        </mml:math>
                                    </disp-formula>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">

                                    <italic toggle="yes">Births
                                        <sub>y</sub>
                                    </italic> represent total number of live births in the state for
                                    <break/>year 
                                    <italic toggle="yes">i</italic>, and 
                                    <italic toggle="yes">CBR</italic> represents the crude birth rate. We used
                                    <break/>the same CBR for all states over the period of estimation</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">1</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Expected
                                    <break/>mortality rate for
                                    <break/>each year</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <disp-formula>
                                        <mml:math display="block" id="math3">
                                            <mml:mrow>
                                                <mml:mi>M</mml:mi>
                                                <mml:msub>
                                                    <mml:mi>R</mml:mi>
                                                    <mml:mi>t</mml:mi>
                                                </mml:msub>
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                                                <mml:msub>
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                                                        <mml:mn>1</mml:mn>
                                                        <mml:msup>
                                                            <mml:mspace width="0.000em"/>
                                                            <mml:mi mathvariant="italic">aarc</mml:mi>
                                                        </mml:msup>
                                                    </mml:mrow>
                                                </mml:msub>
                                            </mml:mrow>
                                        </mml:math>
                                    </disp-formula>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">

                                    <italic toggle="yes">MR
                                        <sub>t</sub>
                                    </italic> is the mortality rate for the index year, 
                                    <italic toggle="yes">MR</italic>
                                    <sub>
                                        <italic toggle="yes">t</italic>&#x2013;1</sub> is the
                                    <break/>mortality rate in the previous year, and 
                                    <italic toggle="yes">aarc</italic> is the average
                                    <break/>annual rate of change in mortality rate assumed for that
                                    <break/>scenario.</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">2</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Annual number of
                                    <break/>under-five deaths
                                    <break/>for each scenario</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <disp-formula>
                                        <mml:math display="block" id="math4">
                                            <mml:mrow>
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                                                        <mml:mi>y</mml:mi>
                                                    </mml:mrow>
                                                </mml:msub>
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                                                <mml:mstyle displaystyle="true">
                                                    <mml:munderover>
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                                                            <mml:mo>=</mml:mo>
                                                            <mml:mn>0</mml:mn>
                                                        </mml:mrow>
                                                        <mml:mn>4</mml:mn>
                                                    </mml:munderover>
                                                    <mml:mrow>
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                                                            <mml:mrow>
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                                                        <mml:mi>U</mml:mi>
                                                        <mml:mn>5</mml:mn>
                                                        <mml:mspace width="0.3em"/>
                                                        <mml:mi>D</mml:mi>
                                                        <mml:mi>e</mml:mi>
                                                        <mml:mi>a</mml:mi>
                                                        <mml:mi>t</mml:mi>
                                                        <mml:mi>h</mml:mi>
                                                        <mml:msub>
                                                            <mml:mi>s</mml:mi>
                                                            <mml:mrow>
                                                                <mml:mi>y</mml:mi>
                                                                <mml:mo>&#x2212;</mml:mo>
                                                                <mml:mi>i</mml:mi>
                                                            </mml:mrow>
                                                        </mml:msub>
                                                    </mml:mrow>
                                                </mml:mstyle>
                                            </mml:mrow>
                                        </mml:math>
                                    </disp-formula> </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">

                                    <italic toggle="yes">s</italic> represents the scenario, 
                                    <italic toggle="yes">x</italic> represents the mortality
                                    <break/>fraction (see 
                                    <xref ref-type="table" rid="T8">Table 8</xref>), and 
                                    <italic toggle="yes">y</italic> represents the index year.
                                    <break/>
                                    <italic toggle="yes">Cohort U</italic>5 
                                    <italic toggle="yes">Deaths</italic>
                                    <sub>
                                        <italic toggle="yes">y</italic>&#x2013;0</sub> represents total number of deaths
                                    <break/>occurring to the birth cohort of the index year, while
                                    <break/>
                                    <italic toggle="yes">Cohort U</italic>5 
                                    <italic toggle="yes">Deaths</italic>
                                    <sub>
                                        <italic toggle="yes">y&#x2013;i</italic>
                                    </sub> represents the total number of deaths
                                    <break/>occurring to the birth cohort of 
                                    <italic toggle="yes">i</italic> years prior to the index
                                    <break/>year.</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">3</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Total deaths in
                                    <break/>scenario s for the
                                    <break/>birth cohort of
                                    <break/>year y over the
                                    <break/>first five years of
                                    <break/>life (i.e. y to y+4)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <disp-formula>
                                        <mml:math display="block" id="math5">
                                            <mml:mrow>
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                                                <mml:mi>U</mml:mi>
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                                                <mml:mi>D</mml:mi>
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                                                        <mml:mi>y</mml:mi>
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                                                <mml:mi>U</mml:mi>
                                                <mml:mn>5</mml:mn>
                                                <mml:mi>M</mml:mi>
                                                <mml:msub>
                                                    <mml:mi>R</mml:mi>
                                                    <mml:mrow>
                                                        <mml:mi>s</mml:mi>
                                                        <mml:mo>,</mml:mo>
                                                        <mml:mi>y</mml:mi>
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                                                <mml:mi>T</mml:mi>
                                                <mml:mi>o</mml:mi>
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                                                <mml:mi>h</mml:mi>
                                                <mml:msub>
                                                    <mml:mi>s</mml:mi>
                                                    <mml:mi>y</mml:mi>
                                                </mml:msub>
                                            </mml:mrow>
                                        </mml:math>
                                    </disp-formula>
                                </td>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">4</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Under-five
                                    <break/>mortality rate
                                    <break/>(U5MR) in
                                    <break/>scenario s, for
                                    <break/>year y</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <disp-formula>
                                        <mml:math display="block" id="math6">
                                            <mml:mrow>
                                                <mml:mi>U</mml:mi>
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                                                <mml:mi>M</mml:mi>
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                                                    <mml:mi>R</mml:mi>
                                                    <mml:mrow>
                                                        <mml:mi>s</mml:mi>
                                                        <mml:mo>,</mml:mo>
                                                        <mml:mi>y</mml:mi>
                                                    </mml:mrow>
                                                </mml:msub>
                                                <mml:mo>=</mml:mo>
                                                <mml:mi>U</mml:mi>
                                                <mml:mn>5</mml:mn>
                                                <mml:mi>M</mml:mi>
                                                <mml:msub>
                                                    <mml:mi>R</mml:mi>
                                                    <mml:mrow>
                                                        <mml:mi>s</mml:mi>
                                                        <mml:mo>,</mml:mo>
                                                        <mml:mi>y</mml:mi>
                                                        <mml:mo>&#x2212;</mml:mo>
                                                        <mml:mi>t</mml:mi>
                                                    </mml:mrow>
                                                </mml:msub>
                                                <mml:mo>&#x2217;</mml:mo>
                                                <mml:mspace width="0.3em"/>
                                                <mml:msup>
                                                    <mml:mi>e</mml:mi>
                                                    <mml:mrow>
                                                        <mml:mi>a</mml:mi>
                                                        <mml:mi>a</mml:mi>
                                                        <mml:mi>r</mml:mi>
                                                        <mml:msub>
                                                            <mml:mi>c</mml:mi>
                                                            <mml:mi>s</mml:mi>
                                                        </mml:msub>
                                                        <mml:mo>&#x2217;</mml:mo>
                                                        <mml:mi>t</mml:mi>
                                                    </mml:mrow>
                                                </mml:msup>
                                            </mml:mrow>
                                        </mml:math>
                                    </disp-formula> </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <italic toggle="yes">aarc
                                        <sub>s</sub>
                                    </italic> represents average annual rate of change of
                                    <break/>mortality rate in scenario 
                                    <italic toggle="yes">s</italic>, 
                                    <italic toggle="yes">U</italic>5
                                    <italic toggle="yes">MR</italic> represents under-five
                                    <break/>mortality rate, and 
                                    <italic toggle="yes">t</italic> represents continuous time interval</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
            </sec>
            <sec>
                <title>ii) Measuring progress towards SDG targets for neonatal and under-five mortality rates</title>
                <p>For each state, we estimated the required average annual rate of decline (AARD) needed for the state to achieve the SDG neonatal mortality target of 12 deaths per 1000 live births and the SDG under-five mortality target of 25 deaths per 1000 live births.</p>
                <p>To assess if states were on track to meet their SDG targets for NMR and U5MR, we calculated historical trends in AARD for each state using mortality rate estimates reported in the Nigeria Demographic and Health Surveys (NDHS) of 2003, 2008, and 2013. Like the 2016&#x2013;17 MICS (and unlike previous MICS), the previous NDHS used direct estimation of child mortality through full birth histories so it was possible to compute trends over the timeframe of interest. We calculated separate estimates for NMR and U5MR for five-year periods (2003 to 2008, and 2008 to 2013), with the assumption that mortality rates changed using exponential decay over the period. Then, we applied the annual rate of decline for each state to the its 2017 mortality rate estimates to project how long it would take for that state to achieve its SDG targets for NMR and U5MR. Since state-level estimates were not available prior to 2011, we calculated AARDs for each of the six regions in the country using equation 1 in 
                    <xref ref-type="table" rid="T1">Table 1</xref>, and applied the regional AARD to all the states in the region.</p>
            </sec>
            <sec>
                <title>iii) Quantifying avertable deaths between 2018 to 2030</title>
                <p>To quantify the number of avertable deaths between 2018 and 2030 from potential improvements in neonatal and under-five mortality, we applied our projections of state-level mortality rate estimates to state-level population projections from the Nigeria National Population Commission for four different scenarios and computed the difference.</p>
                <p>First, we modelled a baseline &#x201c;do nothing&#x201d; (or &#x201c;business as usual&#x201d;) scenario, where we assumed that NMR and U5MR do not change from 2017 levels, i.e., they remain unchanged between 2017 and 2030. The second, &#x201c;historical trends&#x201d; scenario assumed that states will experience AARD trends similar to the trends they experienced in the period leading up to the MDGs. In this scenario, each state starts out with its NMR and U5MR for 2017, and then experiences an annual reduction in both mortality rate estimates between 2018 and 2030 based on its historical AARD estimates. In our third, &#x201c;best in country&#x201d; scenario, we assumed that between 2018 and 2030, each state in the country would attain the AARD observed in the best performing zone during the years leading up to the MDGs. Finally, we modeled an &#x201c;SDG target&#x201d; scenario where we assumed that between 2018 and 2030, each state will experience the AARD that is required for it to achieve the NMR and U5MR SDG targets by 2030.</p>
                <p>In all four scenarios, we estimated the number of neonatal and under-five deaths that would occur for each year between 2018 and 2030 using mortality fractions (see 
                    <xref ref-type="table" rid="T2">Table 2</xref>) and estimates of average annual rates of change in mortality rates (see 
                    <xref ref-type="table" rid="T3">Table 3</xref>). Deaths averted were then calculated by subtracting the number of deaths from each scenario from the number of deaths calculated for the &#x201c;do nothing&#x201d; scenario.</p>
                <table-wrap id="T2" orientation="portrait" position="anchor">
                    <label>Table 2. </label>
                    <caption>
                        <title>Proportion of under-five deaths occurring in each of the first five years of life.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="center" colspan="1" rowspan="1">Period</th>
                                <th align="center" colspan="1" rowspan="1">Number of deaths</th>
                                <th align="center" colspan="1" rowspan="1">Percent of total</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="center" colspan="1" rowspan="1">Year 1</td>
                                <td align="center" colspan="1" rowspan="1">3,047</td>
                                <td align="center" colspan="1" rowspan="1">52%</td>
                            </tr>
                            <tr>
                                <td align="center" colspan="1" rowspan="1">Year 2</td>
                                <td align="center" colspan="1" rowspan="1">1,330</td>
                                <td align="center" colspan="1" rowspan="1">23%</td>
                            </tr>
                            <tr>
                                <td align="center" colspan="1" rowspan="1">Year 3</td>
                                <td align="center" colspan="1" rowspan="1">1,004</td>
                                <td align="center" colspan="1" rowspan="1">17%</td>
                            </tr>
                            <tr>
                                <td align="center" colspan="1" rowspan="1">Year 4</td>
                                <td align="center" colspan="1" rowspan="1">349</td>
                                <td align="center" colspan="1" rowspan="1">6%</td>
                            </tr>
                            <tr>
                                <td align="center" colspan="1" rowspan="1">Year 5</td>
                                <td align="center" colspan="1" rowspan="1">145</td>
                                <td align="center" colspan="1" rowspan="1">2%</td>
                            </tr>
                            <tr>
                                <td align="center" colspan="1" rowspan="1">

                                    <bold>Total</bold>
</td>
                                <td align="center" colspan="1" rowspan="1">

                                    <bold>5,875</bold>
</td>
                                <td align="center" colspan="1" rowspan="1">

                                    <bold>100%</bold>
</td>
                            </tr>
                        </tbody>
                    </table>
                    <table-wrap-foot>
                        <fn>
                            <p>Source: Authors calculations using MICS 2016&#x2013;2017 data of all under-five deaths reported in the five years prior to the survey.</p>
                        </fn>
                    </table-wrap-foot>
                </table-wrap>
                <table-wrap id="T3" orientation="portrait" position="anchor">
                    <label>Table 3. </label>
                    <caption>
                        <title>Average Annual Rates of Change (AARC) between 2008 and 2013 computed from Nigeria Demographic and Health Surveys.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th colspan="1" rowspan="1"/>
                                <th align="center" colspan="3" rowspan="1">NMR</th>
                                <th align="center" colspan="3" rowspan="1">U5MR</th>
                            </tr>
                            <tr>
                                <th align="left" colspan="1" rowspan="1">Geo-political zone</th>
                                <th align="center" colspan="1" rowspan="1">AARC
                                    <break/>(2003 &#x2013; 2013)</th>
                                <th align="center" colspan="1" rowspan="1">AARC
                                    <break/>(2008 &#x2013; 2013)</th>
                                <th align="center" colspan="1" rowspan="1">Best rate</th>
                                <th align="center" colspan="1" rowspan="1">AARC
                                    <break/>(2003 &#x2013; 2013)</th>
                                <th align="center" colspan="1" rowspan="1">AARC
                                    <break/>(2008 &#x2013; 2013)</th>
                                <th align="center" colspan="1" rowspan="1">Best rate</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">National</td>
                                <td align="center" colspan="1" rowspan="1">-2.6</td>
                                <td align="center" colspan="1" rowspan="1">-1.4</td>
                                <td align="center" colspan="1" rowspan="1">-2.6</td>
                                <td align="center" colspan="1" rowspan="1">-4.5</td>
                                <td align="center" colspan="1" rowspan="1">-4.0</td>
                                <td align="center" colspan="1" rowspan="1">-4.5</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">North-Central</td>
                                <td align="center" colspan="1" rowspan="1">-4.2</td>
                                <td align="center" colspan="1" rowspan="1">-2.9</td>
                                <td align="center" colspan="1" rowspan="1">-4.2</td>
                                <td align="center" colspan="1" rowspan="1">-5.0</td>
                                <td align="center" colspan="1" rowspan="1">-5.9</td>
                                <td align="center" colspan="1" rowspan="1">-5.9</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">North-East</td>
                                <td align="center" colspan="1" rowspan="1">-3.3</td>
                                <td align="center" colspan="1" rowspan="1">-4.0</td>
                                <td align="center" colspan="1" rowspan="1">-4.0</td>
                                <td align="center" colspan="1" rowspan="1">-4.8</td>
                                <td align="center" colspan="1" rowspan="1">-6.5</td>
                                <td align="center" colspan="1" rowspan="1">-6.5</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">North-West</td>
                                <td align="center" colspan="1" rowspan="1">-2.4</td>
                                <td align="center" colspan="1" rowspan="1">-1.4</td>
                                <td align="center" colspan="1" rowspan="1">-2.4</td>
                                <td align="center" colspan="1" rowspan="1">-3.7</td>
                                <td align="center" colspan="1" rowspan="1">-3.2</td>
                                <td align="center" colspan="1" rowspan="1">-3.7</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">South-East</td>
                                <td align="center" colspan="1" rowspan="1">0.9</td>
                                <td align="center" colspan="1" rowspan="1">-6.3</td>
                                <td align="center" colspan="1" rowspan="1">-6.3</td>
                                <td align="center" colspan="1" rowspan="1">2.5</td>
                                <td align="center" colspan="1" rowspan="1">-3.1</td>
                                <td align="center" colspan="1" rowspan="1">-3.1</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">South-South</td>
                                <td align="center" colspan="1" rowspan="1">-5.0</td>
                                <td align="center" colspan="1" rowspan="1">-8.0</td>
                                <td align="center" colspan="1" rowspan="1">-8.0</td>
                                <td align="center" colspan="1" rowspan="1">-6.6</td>
                                <td align="center" colspan="1" rowspan="1">-8.4</td>
                                <td align="center" colspan="1" rowspan="1">-8.4</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">South-West</td>
                                <td align="center" colspan="1" rowspan="1">0.0</td>
                                <td align="center" colspan="1" rowspan="1">1.3</td>
                                <td align="center" colspan="1" rowspan="1">0.0</td>
                                <td align="center" colspan="1" rowspan="1">-2.3</td>
                                <td align="center" colspan="1" rowspan="1">0.2</td>
                                <td align="center" colspan="1" rowspan="1">-2.3</td>
                            </tr>
                        </tbody>
                    </table>
                    <table-wrap-foot>
                        <fn>
                            <p>Source: Authors calculations using datasets from Nigeria Demographic and Health Surveys 2003, 2008, and 2013.</p>
                            <p>
                                <underline>Notes:</underline>
                            </p>
                            <p>1. Average Annual Rate of Change (AARC) was calculated using the formula: 
                                <inline-formula>
                                    <mml:math display="inline" id="M1">
                                        <mml:mrow>
                                            <mml:mi>A</mml:mi>
                                            <mml:mi>A</mml:mi>
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                                            <mml:mo>=</mml:mo>
                                            <mml:mfrac>
                                                <mml:mrow>
                                                    <mml:mrow>
                                                        <mml:mo>(</mml:mo>
                                                        <mml:mrow>
                                                            <mml:mstyle scriptlevel="1">
                                                                <mml:mfrac bevelled="true">
                                                                    <mml:mrow>
                                                                        <mml:mi>M</mml:mi>
                                                                        <mml:msub>
                                                                            <mml:mi>R</mml:mi>
                                                                            <mml:mrow>
                                                                                <mml:mi>e</mml:mi>
                                                                                <mml:mi>n</mml:mi>
                                                                                <mml:mi>d</mml:mi>
                                                                            </mml:mrow>
                                                                        </mml:msub>
                                                                    </mml:mrow>
                                                                    <mml:mrow>
                                                                        <mml:mi>M</mml:mi>
                                                                        <mml:msub>
                                                                            <mml:mi>R</mml:mi>
                                                                            <mml:mrow>
                                                                                <mml:mi>s</mml:mi>
                                                                                <mml:mi>t</mml:mi>
                                                                                <mml:mi>a</mml:mi>
                                                                                <mml:mi>r</mml:mi>
                                                                                <mml:mi>t</mml:mi>
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                                                        </mml:mrow>
                                                        <mml:mo>)</mml:mo>
                                                    </mml:mrow>
                                                </mml:mrow>
                                                <mml:mrow>
                                                    <mml:mi>E</mml:mi>
                                                    <mml:mi>n</mml:mi>
                                                    <mml:mi>d</mml:mi>
                                                    <mml:mo>&#x2212;</mml:mo>
                                                    <mml:mi>S</mml:mi>
                                                    <mml:mi>t</mml:mi>
                                                    <mml:mi>a</mml:mi>
                                                    <mml:mi>r</mml:mi>
                                                    <mml:mi>t</mml:mi>
                                                </mml:mrow>
                                            </mml:mfrac>
                                            <mml:mo>&#x2217;</mml:mo>
                                            <mml:mn>100.</mml:mn>
                                        </mml:mrow>
                                    </mml:math>
                                </inline-formula> Positive values indicate rising neonatal mortality rates while negative values indicate falling neonatal mortality rates.</p>
                        </fn>
                    </table-wrap-foot>
                </table-wrap>
                <p>Finally, we concluded our analysis by ranking states based on their NMR (SDG 3.2.1) and U5MR (SDG 3.2.2) estimates in 2017. We also rank states based on the estimated annual number of neonatal and under-five deaths they have, in order to identify the states that account for most of the burden of neonatal and under-five mortality in Nigeria.</p>
                <p>Mortality rates estimates were computed using 
                    <ext-link ext-link-type="uri" xlink:href="https://www.stata.com/">Stata</ext-link> software version 15.1 and we used Microsoft Excel for Mac version 16.22 to make projections. An expanded description of methods applied is available as Extended data
                    <sup>
                        <xref ref-type="bibr" rid="ref-10">10</xref>
                    </sup>.</p>
            </sec>
        </sec>
        <sec sec-type="results">
            <title>Results</title>
            <sec>
                <title>i) Neonatal mortality rates and progress towards SDG 3.2.1</title>
                <p>
                    <xref ref-type="table" rid="T4">Table 4</xref> shows our estimates of the national and state NMRs from MICS 2016&#x2013;2017. The estimated national NMR in 2017 was 37 per 1,000 live births (95% CI: 36-39). But at the state level, NMR ranged from 12 per 1,000 live births (95% CI: 7-22) in Kwara state to 65 per 1,000 live births (95% CI: 59-72) in Kano state.</p>
                <table-wrap id="T4" orientation="portrait" position="anchor">
                    <label>Table 4. </label>
                    <caption>
                        <title>State-level trends in neonatal mortality rates (NMR) and progress towards achieving sustainable development goals (SDG) target for NMR.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="center" colspan="1" rowspan="1" valign="bottom"/>
                                <th align="center" colspan="1" rowspan="1" valign="bottom"/>
                                <th align="center" colspan="1" rowspan="1" valign="bottom"/>
                                <th align="center" colspan="4" rowspan="1" valign="bottom">SDG scenarios</th>
                            </tr>
                            <tr>
                                <th align="center" colspan="1" rowspan="1" valign="bottom"/>
                                <th align="center" colspan="1" rowspan="1" valign="bottom"/>
                                <th align="center" colspan="1" rowspan="1" valign="bottom"/>
                                <th align="center" colspan="2" rowspan="1" valign="bottom">At current AARC (2003&#x2013;2013)</th>
                                <th align="center" colspan="2" rowspan="1" valign="bottom">At best in-country AARC (2003&#x2013;2013)</th>
                            </tr>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="bottom">State</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">Neonatal mortality
                                    <break/>rate (2017)</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">Required AARC to
                                    <break/>reach SDG target</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">Year SDG target
                                    <break/>will be met</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">Number of years delay
                                    <break/>beyond 2030</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">Year SDG target
                                    <break/>will be met</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">Number of years
                                    <break/>delayed</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">
                                    <bold>North-Central</bold>
                                </td>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Benue</td>
                                <td align="center" colspan="1" rowspan="1">34 (25, 45)</td>
                                <td align="center" colspan="1" rowspan="1">-8</td>
                                <td align="center" colspan="1" rowspan="1">2042</td>
                                <td align="center" colspan="1" rowspan="1">12</td>
                                <td align="center" colspan="1" rowspan="1">2030</td>
                                <td align="center" colspan="1" rowspan="1">0</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;FCT Abuja</td>
                                <td align="center" colspan="1" rowspan="1">23 (17, 32)</td>
                                <td align="center" colspan="1" rowspan="1">-5</td>
                                <td align="center" colspan="1" rowspan="1">2033</td>
                                <td align="center" colspan="1" rowspan="1">3</td>
                                <td align="center" colspan="1" rowspan="1">2025</td>
                                <td align="center" colspan="1" rowspan="1">3 years early</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Kogi</td>
                                <td align="center" colspan="1" rowspan="1">39 (29, 53)</td>
                                <td align="center" colspan="1" rowspan="1">-9</td>
                                <td align="center" colspan="1" rowspan="1">2045</td>
                                <td align="center" colspan="1" rowspan="1">15</td>
                                <td align="center" colspan="1" rowspan="1">2032</td>
                                <td align="center" colspan="1" rowspan="1">On track</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Kwara</td>
                                <td align="center" colspan="1" rowspan="1">12 (7, 22)</td>
                                <td align="center" colspan="1" rowspan="1">0</td>
                                <td align="center" colspan="1" rowspan="1">2018</td>
                                <td align="center" colspan="1" rowspan="1">SDG target met</td>
                                <td align="center" colspan="1" rowspan="1">2017</td>
                                <td align="center" colspan="1" rowspan="1">SDG target met</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Nasarawa</td>
                                <td align="center" colspan="1" rowspan="1">47 (39, 58)</td>
                                <td align="center" colspan="1" rowspan="1">-11</td>
                                <td align="center" colspan="1" rowspan="1">2050</td>
                                <td align="center" colspan="1" rowspan="1">20</td>
                                <td align="center" colspan="1" rowspan="1">2034</td>
                                <td align="center" colspan="1" rowspan="1">4</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Niger</td>
                                <td align="center" colspan="1" rowspan="1">50 (42, 60)</td>
                                <td align="center" colspan="1" rowspan="1">-11</td>
                                <td align="center" colspan="1" rowspan="1">2051</td>
                                <td align="center" colspan="1" rowspan="1">21</td>
                                <td align="center" colspan="1" rowspan="1">2035</td>
                                <td align="center" colspan="1" rowspan="1">5</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Plateau</td>
                                <td align="center" colspan="1" rowspan="1">39 (31, 49)</td>
                                <td align="center" colspan="1" rowspan="1">-9</td>
                                <td align="center" colspan="1" rowspan="1">2045</td>
                                <td align="center" colspan="1" rowspan="1">15</td>
                                <td align="center" colspan="1" rowspan="1">2032</td>
                                <td align="center" colspan="1" rowspan="1">On track</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">
                                    <bold>North-East</bold>
                                </td>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Adamawa</td>
                                <td align="center" colspan="1" rowspan="1">20 (14, 29)</td>
                                <td align="center" colspan="1" rowspan="1">-4</td>
                                <td align="center" colspan="1" rowspan="1">2030</td>
                                <td align="center" colspan="1" rowspan="1">1 year early</td>
                                <td align="center" colspan="1" rowspan="1">2024</td>
                                <td align="center" colspan="1" rowspan="1">7 years early</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Bauchi</td>
                                <td align="center" colspan="1" rowspan="1">41 (33, 49)</td>
                                <td align="center" colspan="1" rowspan="1">-9</td>
                                <td align="center" colspan="1" rowspan="1">2047</td>
                                <td align="center" colspan="1" rowspan="1">17</td>
                                <td align="center" colspan="1" rowspan="1">2032</td>
                                <td align="center" colspan="1" rowspan="1">2</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Borno</td>
                                <td align="center" colspan="1" rowspan="1">30 (20, 45)</td>
                                <td align="center" colspan="1" rowspan="1">-7</td>
                                <td align="center" colspan="1" rowspan="1">2040</td>
                                <td align="center" colspan="1" rowspan="1">10</td>
                                <td align="center" colspan="1" rowspan="1">2029</td>
                                <td align="center" colspan="1" rowspan="1">1 year early</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Gombe</td>
                                <td align="center" colspan="1" rowspan="1">32 (25, 41)</td>
                                <td align="center" colspan="1" rowspan="1">-7</td>
                                <td align="center" colspan="1" rowspan="1">2041</td>
                                <td align="center" colspan="1" rowspan="1">11</td>
                                <td align="center" colspan="1" rowspan="1">2029</td>
                                <td align="center" colspan="1" rowspan="1">1 year early</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Taraba</td>
                                <td align="center" colspan="1" rowspan="1">17 (11, 26)</td>
                                <td align="center" colspan="1" rowspan="1">-3</td>
                                <td align="center" colspan="1" rowspan="1">2026</td>
                                <td align="center" colspan="1" rowspan="1">4 years early</td>
                                <td align="center" colspan="1" rowspan="1">2022</td>
                                <td align="center" colspan="1" rowspan="1">2 years early</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Yobe</td>
                                <td align="center" colspan="1" rowspan="1">39 (31, 49)</td>
                                <td align="center" colspan="1" rowspan="1">-9</td>
                                <td align="center" colspan="1" rowspan="1">2046</td>
                                <td align="center" colspan="1" rowspan="1">16</td>
                                <td align="center" colspan="1" rowspan="1">2032</td>
                                <td align="center" colspan="1" rowspan="1">2</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">
                                    <bold>North-West</bold>
				</td>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Jigawa</td>
                                <td align="center" colspan="1" rowspan="1">30 (24, 38)</td>
                                <td align="center" colspan="1" rowspan="1">-7</td>
                                <td align="center" colspan="1" rowspan="1">2056</td>
                                <td align="center" colspan="1" rowspan="1">26</td>
                                <td align="center" colspan="1" rowspan="1">2029</td>
                                <td align="center" colspan="1" rowspan="1">On track</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Kaduna</td>
                                <td align="center" colspan="1" rowspan="1">29 (22, 38)</td>
                                <td align="center" colspan="1" rowspan="1">-7</td>
                                <td align="center" colspan="1" rowspan="1">2054</td>
                                <td align="center" colspan="1" rowspan="1">24</td>
                                <td align="center" colspan="1" rowspan="1">2028</td>
                                <td align="center" colspan="1" rowspan="1">2 years early</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Kano</td>
                                <td align="center" colspan="1" rowspan="1">65 (59, 72)</td>
                                <td align="center" colspan="1" rowspan="1">-13</td>
                                <td align="center" colspan="1" rowspan="1">2088</td>
                                <td align="center" colspan="1" rowspan="1">58</td>
                                <td align="center" colspan="1" rowspan="1">2038</td>
                                <td align="center" colspan="1" rowspan="1">8</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Katsina</td>
                                <td align="center" colspan="1" rowspan="1">37 (30, 45)</td>
                                <td align="center" colspan="1" rowspan="1">-9</td>
                                <td align="center" colspan="1" rowspan="1">2064</td>
                                <td align="center" colspan="1" rowspan="1">34</td>
                                <td align="center" colspan="1" rowspan="1">2031</td>
                                <td align="center" colspan="1" rowspan="1">1</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Kebbi</td>
                                <td align="center" colspan="1" rowspan="1">44 (37, 54)</td>
                                <td align="center" colspan="1" rowspan="1">-10</td>
                                <td align="center" colspan="1" rowspan="1">2072</td>
                                <td align="center" colspan="1" rowspan="1">42</td>
                                <td align="center" colspan="1" rowspan="1">2033</td>
                                <td align="center" colspan="1" rowspan="1">3</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Sokoto</td>
                                <td align="center" colspan="1" rowspan="1">40 (32, 49)</td>
                                <td align="center" colspan="1" rowspan="1">-9</td>
                                <td align="center" colspan="1" rowspan="1">2068</td>
                                <td align="center" colspan="1" rowspan="1">38</td>
                                <td align="center" colspan="1" rowspan="1">2032</td>
                                <td align="center" colspan="1" rowspan="1">On track</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Zamfara</td>
                                <td align="center" colspan="1" rowspan="1">52 (45, 62)</td>
                                <td align="center" colspan="1" rowspan="1">-11</td>
                                <td align="center" colspan="1" rowspan="1">2079</td>
                                <td align="center" colspan="1" rowspan="1">49</td>
                                <td align="center" colspan="1" rowspan="1">2035</td>
                                <td align="center" colspan="1" rowspan="1">5</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">
                                    <bold>South-East</bold>
				</td>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Abia</td>
                                <td align="center" colspan="1" rowspan="1">30 (21, 44)</td>
                                <td align="center" colspan="1" rowspan="1">-7</td>
                                <td align="center" colspan="1" rowspan="1">2032</td>
                                <td align="center" colspan="1" rowspan="1">2</td>
                                <td align="center" colspan="1" rowspan="1">2029</td>
                                <td align="center" colspan="1" rowspan="1">On track</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Anambra</td>
                                <td align="center" colspan="1" rowspan="1">21 (13, 32)</td>
                                <td align="center" colspan="1" rowspan="1">-4</td>
                                <td align="center" colspan="1" rowspan="1">2026</td>
                                <td align="center" colspan="1" rowspan="1">3 years early</td>
                                <td align="center" colspan="1" rowspan="1">2024</td>
                                <td align="center" colspan="1" rowspan="1">5 years early</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Ebonyi</td>
                                <td align="center" colspan="1" rowspan="1">22 (14, 33)</td>
                                <td align="center" colspan="1" rowspan="1">-5</td>
                                <td align="center" colspan="1" rowspan="1">2026</td>
                                <td align="center" colspan="1" rowspan="1">4 years early</td>
                                <td align="center" colspan="1" rowspan="1">2024</td>
                                <td align="center" colspan="1" rowspan="1">1 year early</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Enugu</td>
                                <td align="center" colspan="1" rowspan="1">23 (15, 37)</td>
                                <td align="center" colspan="1" rowspan="1">-5</td>
                                <td align="center" colspan="1" rowspan="1">2028</td>
                                <td align="center" colspan="1" rowspan="1">2 years early</td>
                                <td align="center" colspan="1" rowspan="1">2025</td>
                                <td align="center" colspan="1" rowspan="1">5 years early</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Imo</td>
                                <td align="center" colspan="1" rowspan="1">29 (20, 42)</td>
                                <td align="center" colspan="1" rowspan="1">-7</td>
                                <td align="center" colspan="1" rowspan="1">2031</td>
                                <td align="center" colspan="1" rowspan="1">1</td>
                                <td align="center" colspan="1" rowspan="1">2028</td>
                                <td align="center" colspan="1" rowspan="1">1 year early</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">
                                    <bold>South-South</bold>
				</td>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Akwa Ibom</td>
                                <td align="center" colspan="1" rowspan="1">26 (19, 37)</td>
                                <td align="center" colspan="1" rowspan="1">-6</td>
                                <td align="center" colspan="1" rowspan="1">2027</td>
                                <td align="center" colspan="1" rowspan="1">3 years early</td>
                                <td align="center" colspan="1" rowspan="1">2027</td>
                                <td align="center" colspan="1" rowspan="1">3 years early</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Bayelsa</td>
                                <td align="center" colspan="1" rowspan="1">34 (25, 46)</td>
                                <td align="center" colspan="1" rowspan="1">-8</td>
                                <td align="center" colspan="1" rowspan="1">2030</td>
                                <td align="center" colspan="1" rowspan="1">On track</td>
                                <td align="center" colspan="1" rowspan="1">2030</td>
                                <td align="center" colspan="1" rowspan="1">On track</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Cross River</td>
                                <td align="center" colspan="1" rowspan="1">18 (11, 29)</td>
                                <td align="center" colspan="1" rowspan="1">-3</td>
                                <td align="center" colspan="1" rowspan="1">2022</td>
                                <td align="center" colspan="1" rowspan="1">8 years early</td>
                                <td align="center" colspan="1" rowspan="1">2022</td>
                                <td align="center" colspan="1" rowspan="1">8 years early</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Delta</td>
                                <td align="center" colspan="1" rowspan="1">28 (20, 41)</td>
                                <td align="center" colspan="1" rowspan="1">-7</td>
                                <td align="center" colspan="1" rowspan="1">2028</td>
                                <td align="center" colspan="1" rowspan="1">2 years early</td>
                                <td align="center" colspan="1" rowspan="1">2028</td>
                                <td align="center" colspan="1" rowspan="1">2 years early</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Edo</td>
                                <td align="center" colspan="1" rowspan="1">24 (21, 29)</td>
                                <td align="center" colspan="1" rowspan="1">-5</td>
                                <td align="center" colspan="1" rowspan="1">2026</td>
                                <td align="center" colspan="1" rowspan="1">4 years early</td>
                                <td align="center" colspan="1" rowspan="1">2026</td>
                                <td align="center" colspan="1" rowspan="1">4 years early</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Rivers</td>
                                <td align="center" colspan="1" rowspan="1">25 (16, 39)</td>
                                <td align="center" colspan="1" rowspan="1">-6</td>
                                <td align="center" colspan="1" rowspan="1">2026</td>
                                <td align="center" colspan="1" rowspan="1">4 years early</td>
                                <td align="center" colspan="1" rowspan="1">2026</td>
                                <td align="center" colspan="1" rowspan="1">4 years early</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">
                                    <bold>South-West</bold>
                                </td>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Ekiti</td>
                                <td align="center" colspan="1" rowspan="1">38 (26, 57)</td>
                                <td align="center" colspan="1" rowspan="1">-9</td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;2032</td>
                                <td align="center" colspan="1" rowspan="1">2</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Lagos</td>
                                <td align="center" colspan="1" rowspan="1">35 (28, 45)</td>
                                <td align="center" colspan="1" rowspan="1">-8</td>
                                <td align="center" colspan="2" rowspan="3">On average, neonatal mortality rates were
                                    <break/>static or rising every year in the south-west
                                    <break/>zone between 2003 and 2013.</td>
                                <td align="center" colspan="1" rowspan="1">2031</td>
                                <td align="center" colspan="1" rowspan="1">2 years early</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Ogun</td>
                                <td align="center" colspan="1" rowspan="1">32 (22, 47)</td>
                                <td align="center" colspan="1" rowspan="1">-8</td>
                                <td align="center" colspan="1" rowspan="1">2029</td>
                                <td align="center" colspan="1" rowspan="1">2 years early</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Ondo</td>
                                <td align="center" colspan="1" rowspan="1">32 (22, 46)</td>
                                <td align="center" colspan="1" rowspan="1">-8</td>
                                <td align="center" colspan="1" rowspan="1">2029</td>
                                <td align="center" colspan="1" rowspan="1">On track</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Osun</td>
                                <td align="center" colspan="1" rowspan="1">49 (35, 69)</td>
                                <td align="center" colspan="1" rowspan="1">-11</td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1">2035</td>
                                <td align="center" colspan="1" rowspan="1">5</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Oyo</td>
                                <td align="center" colspan="1" rowspan="1">38 (28, 53)</td>
                                <td align="center" colspan="1" rowspan="1">-9</td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1">2032</td>
                                <td align="center" colspan="1" rowspan="1">2</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">
                                    <bold>National</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;37 (36, 39)</td>
                                <td align="center" colspan="1" rowspan="1">
                                    <bold>-9</bold>
                                </td>
                                <td align="center" colspan="1" rowspan="1">
                                    <bold>2060</bold>
                                </td>
                                <td align="center" colspan="1" rowspan="1">
                                    <bold>30</bold>
                                </td>
                                <td align="center" colspan="1" rowspan="1">
                                    <bold>2031</bold>
                                </td>
                                <td align="center" colspan="1" rowspan="1">
                                    <bold>1</bold>
                                </td>
                            </tr>
                        </tbody>
                    </table>
                    <table-wrap-foot>
                        <fn>
                            <p>
				
                                <underline>Notes:</underline>
			</p>
                            <p>1. Neonatal mortality rate (NMR) was defined as the probability that a who was born alive dies in the first month of life, expressed per 1,000 live births. </p>
                            <p>2. Average Annual Rate of Change (AARC) was calculated using the formula: 
                                <inline-formula>
                                    <mml:math display="inline" id="M">
                                        <mml:mrow>
                                            <mml:mi>A</mml:mi>
                                            <mml:mi>A</mml:mi>
                                            <mml:mi>R</mml:mi>
                                            <mml:mi>C</mml:mi>
                                            <mml:mo>=</mml:mo>
                                            <mml:mfrac>
                                                <mml:mrow>
                                                    <mml:mrow>
                                                        <mml:mo>(</mml:mo>
                                                        <mml:mrow>
                                                            <mml:mstyle scriptlevel="1">
                                                                <mml:mfrac bevelled="true">
                                                                    <mml:mrow>
                                                                        <mml:mi>N</mml:mi>
                                                                        <mml:mi>M</mml:mi>
                                                                        <mml:msub>
                                                                            <mml:mi>R</mml:mi>
                                                                            <mml:mrow>
                                                                                <mml:mi>e</mml:mi>
                                                                                <mml:mi>n</mml:mi>
                                                                                <mml:mi>d</mml:mi>
                                                                            </mml:mrow>
                                                                        </mml:msub>
                                                                    </mml:mrow>
                                                                    <mml:mrow>
                                                                        <mml:mi>N</mml:mi>
                                                                        <mml:mi>M</mml:mi>
                                                                        <mml:msub>
                                                                            <mml:mi>R</mml:mi>
                                                                            <mml:mrow>
                                                                                <mml:mi>s</mml:mi>
                                                                                <mml:mi>t</mml:mi>
                                                                                <mml:mi>a</mml:mi>
                                                                                <mml:mi>r</mml:mi>
                                                                                <mml:mi>t</mml:mi>
                                                                            </mml:mrow>
                                                                        </mml:msub>
                                                                    </mml:mrow>
                                                                </mml:mfrac>
                                                            </mml:mstyle>
                                                        </mml:mrow>
                                                        <mml:mo>)</mml:mo>
                                                    </mml:mrow>
                                                </mml:mrow>
                                                <mml:mrow>
                                                    <mml:mi>E</mml:mi>
                                                    <mml:mi>n</mml:mi>
                                                    <mml:mi>d</mml:mi>
                                                    <mml:mo>&#x2212;</mml:mo>
                                                    <mml:mi>S</mml:mi>
                                                    <mml:mi>t</mml:mi>
                                                    <mml:mi>a</mml:mi>
                                                    <mml:mi>r</mml:mi>
                                                    <mml:mi>t</mml:mi>
                                                </mml:mrow>
                                            </mml:mfrac>
                                            <mml:mo>&#x2217;</mml:mo>
                                            <mml:mn>100.</mml:mn>
                                        </mml:mrow>
                                    </mml:math>
                                </inline-formula> Positive values indicate rising neonatal mortality rates while negative values indicate falling neonatal mortality rates.</p>
                            <p>3. Sustainable Development Goals (SDG) target for neonatal mortality rate is 12 deaths per 1000 live births by 2030.</p>
                        </fn>
                    </table-wrap-foot>
                </table-wrap>
                <p>For Nigeria to achieve its SDG target for NMR of 12 deaths per 1,00 live births (SDG 3.2.1), its national NMR will have to decrease by 9% every year, on average, between 2018 and 2030. However, the AARD required to reach SDG 3.2.1 at the state level varies widely. While Kwara state has already achieved the SDG 3.2.1 target, some other states such as Zamfara and Kano will need to achieve an average annual decrease in NMR of 11%, and 13% respectively, in order to meet the NMR SDG targets.</p>
                <p>Our estimates of historical AARD in NMR ranged between 1.4% per year and 2.6% per year at the national level. At the subnational level, the AARD for NMR varied across zones. The South-South zone of the country recorded the largest AARD of 8% per year between 2008 and 2013, while the South-West zone of the country showed worsening NMR in the same period with an increase in NMR 1.3% per year (see 
                    <xref ref-type="table" rid="T3">Table 3</xref>).</p>
                <p>At historical AARDs, Nigeria, as a country, will achieve its SDG target for NMR in 2060, 30 years behind the SDG target year of 2030. However, progress across the different states would vary. At historical rates of decline, 12 out of 37 states would have met or surpassed the SDG NMR target by 2030, while 19 states will achieve the SDG NMR target between 2031 (1 year later) and 2088 (58 years later). We did not estimate target years for the five states in the South-West zone of the country because, unlike other zones, the South-West zone showed 
                    <italic toggle="yes">increases</italic> in NMR between 2003 and 2013 that ranged from 0.3% per year to 1.3% per year. As such, they would be moving away, not towards, the SDG NMR target (See 
                    <xref ref-type="table" rid="T4">Table 4</xref>, and 
                    <xref ref-type="fig" rid="f2">Figure 2A</xref>).</p>
                <fig fig-type="figure" id="f2" orientation="portrait" position="float">
                    <label>Figure 2. </label>
                    <caption>
                        <p>
                            <bold>A</bold>. Year by which each Nigerian state will achieve the sustainable development goals target for neonatal mortality rate (SDG 3.2.1) of 12 per 1,000 live births assuming states maintain recent average annual rates of change. 
                            <bold>B</bold>. Year by which each state will achieve the sustainable development goals target for under-five mortality rate (SDG 3.2.2) of 25 per 1,000 live births assuming states maintain recent average annual rates of change. States below the red line are on track to reach their SDG targets by 2030 while states above the red line ar not on track to reach their SDG targets.</p>
                    </caption>
                    <graphic orientation="portrait" position="float" xlink:href="https://gatesopenresearch-files.f1000.com/manuscripts/14030/46d60af9-208e-44c4-85bc-d98523c0495a_figure2.gif"/>
                </fig>
                <p>However, if between 2018 and 2030, each state maintains an AARD in NMR equal to the best historical rate of decline in the country in the MDG era (i.e. 8% decline per year), Nigeria will achieve its SDG target for NMR in 2031 (1 year behind schedule). In this scenario, 26 out of 37 states will achieve the NMR target for the SDGs while 11 will not. The years in which states will reach NMR targets for SDG range from 2022 (8 years early) to 2038 (8 years behind schedule).</p>
            </sec>
            <sec>
                <title>ii) Under-five mortality rates and progress towards SDG 3.2.2</title>
                <p>At the national level, U5MR in 2017 was 118 per 1,000 live births (95% CI: 115-121), but at the state level, U5MR ranged from 32 per 1,000 live births (95% CI: 23-46) in Kwara state, to 209 per 1,000 live births (95% CI: 193-226) in Zamfara state. Consequently, Nigeria will need to maintain a national AARD in U5MR of 12% per year between 2018 and 2030 in order to meet the SDG target for U5MR of 25 deaths per 1,000 live births (SDG 3.2.2). To achieve SDG 3.2.2 targets at state level, states will have to maintain an AARD that ranges from 2% per year in Kwara state to 16% per year in Kano, Jigawa, and Zamfara states (
                    <xref ref-type="table" rid="T5">Table 5</xref>).</p>
                <table-wrap id="T5" orientation="portrait" position="anchor">
                    <label>Table 5. </label>
                    <caption>
                        <title>State-level trends in under-five mortality rates (U5MR) and progress towards achieving sustainable development goals (SDG) target for U5MR.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="center" colspan="1" rowspan="1" valign="bottom"/>
                                <th align="center" colspan="1" rowspan="1" valign="bottom"/>
                                <th align="center" colspan="1" rowspan="1" valign="bottom"/>
                                <th align="center" colspan="4" rowspan="1" valign="bottom">Sustainable Development Goals (SDG) scenarios</th>
                            </tr>
                            <tr>
                                <th align="center" colspan="1" rowspan="1" valign="bottom"/>
                                <th align="center" colspan="1" rowspan="1" valign="bottom"/>
                                <th align="center" colspan="1" rowspan="1" valign="bottom"/>
                                <th align="center" colspan="2" rowspan="1" valign="bottom">At current AARC (2003&#x2013;2013)</th>
                                <th align="center" colspan="2" rowspan="1" valign="bottom">At best in-country AARC
                                    <break/>(2003&#x2013;2013)</th>
                            </tr>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="bottom">State</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">Under-five mortality
                                    <break/>rate (2017)</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">Required AARC to
                                    <break/>reach SDG target</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">Year SDG target
                                    <break/>will be met</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">Number of years
                                    <break/>delay beyond
                                    <break/>2030</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">Year SDG
                                    <break/>target will
                                    <break/>be met</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">Number of
                                    <break/>years delayed</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">
                                    <bold>North-Central</bold>
                                </td>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Benue</td>
                                <td align="center" colspan="1" rowspan="1">73 (60, 90)</td>
                                <td align="center" colspan="1" rowspan="1">-8</td>
                                <td align="center" colspan="1" rowspan="1">2035</td>
                                <td align="center" colspan="1" rowspan="1">5</td>
                                <td align="center" colspan="1" rowspan="1">2030</td>
                                <td align="center" colspan="1" rowspan="1">On target</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;FCT Abuja</td>
                                <td align="center" colspan="1" rowspan="1">71 (59, 87)</td>
                                <td align="center" colspan="1" rowspan="1">-8</td>
                                <td align="center" colspan="1" rowspan="1">2035</td>
                                <td align="center" colspan="1" rowspan="1">5</td>
                                <td align="center" colspan="1" rowspan="1">2030</td>
                                <td align="center" colspan="1" rowspan="1">On target</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Kogi</td>
                                <td align="center" colspan="1" rowspan="1">93 (76, 114)</td>
                                <td align="center" colspan="1" rowspan="1">-10</td>
                                <td align="center" colspan="1" rowspan="1">2039</td>
                                <td align="center" colspan="1" rowspan="1">9</td>
                                <td align="center" colspan="1" rowspan="1">2033</td>
                                <td align="center" colspan="1" rowspan="1">3</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Kwara</td>
                                <td align="center" colspan="1" rowspan="1">32 (23, 46)</td>
                                <td align="center" colspan="1" rowspan="1">-2</td>
                                <td align="center" colspan="1" rowspan="1">2021</td>
                                <td align="center" colspan="1" rowspan="1">-9</td>
                                <td align="center" colspan="1" rowspan="1">2020</td>
                                <td align="center" colspan="1" rowspan="1">10 years early</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Nasarawa</td>
                                <td align="center" colspan="1" rowspan="1">120 (105, 137)</td>
                                <td align="center" colspan="1" rowspan="1">-12</td>
                                <td align="center" colspan="1" rowspan="1">2044</td>
                                <td align="center" colspan="1" rowspan="1">14</td>
                                <td align="center" colspan="1" rowspan="1">2036</td>
                                <td align="center" colspan="1" rowspan="1">6</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Niger</td>
                                <td align="center" colspan="1" rowspan="1">129 (115, 145)</td>
                                <td align="center" colspan="1" rowspan="1">-13</td>
                                <td align="center" colspan="1" rowspan="1">2045</td>
                                <td align="center" colspan="1" rowspan="1">15</td>
                                <td align="center" colspan="1" rowspan="1">2037</td>
                                <td align="center" colspan="1" rowspan="1">7</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Plateau</td>
                                <td align="center" colspan="1" rowspan="1">97 (83, 112)</td>
                                <td align="center" colspan="1" rowspan="1">-10</td>
                                <td align="center" colspan="1" rowspan="1">2040</td>
                                <td align="center" colspan="1" rowspan="1">10</td>
                                <td align="center" colspan="1" rowspan="1">2033</td>
                                <td align="center" colspan="1" rowspan="1">3</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">
                                    <bold>North-East</bold>
                                </td>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Adamawa</td>
                                <td align="center" colspan="1" rowspan="1">87 (73, 103)</td>
                                <td align="center" colspan="1" rowspan="1">-10</td>
                                <td align="center" colspan="1" rowspan="1">2036</td>
                                <td align="center" colspan="1" rowspan="1">6</td>
                                <td align="center" colspan="1" rowspan="1">2032</td>
                                <td align="center" colspan="1" rowspan="1">2</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Bauchi</td>
                                <td align="center" colspan="1" rowspan="1">154 (139, 170)</td>
                                <td align="center" colspan="1" rowspan="1">-14</td>
                                <td align="center" colspan="1" rowspan="1">2045</td>
                                <td align="center" colspan="1" rowspan="1">15</td>
                                <td align="center" colspan="1" rowspan="1">2039</td>
                                <td align="center" colspan="1" rowspan="1">9</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Borno</td>
                                <td align="center" colspan="1" rowspan="1">115 (94, 142)</td>
                                <td align="center" colspan="1" rowspan="1">-12</td>
                                <td align="center" colspan="1" rowspan="1">2040</td>
                                <td align="center" colspan="1" rowspan="1">10</td>
                                <td align="center" colspan="1" rowspan="1">2035</td>
                                <td align="center" colspan="1" rowspan="1">5</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Gombe</td>
                                <td align="center" colspan="1" rowspan="1">151 (134, 169)</td>
                                <td align="center" colspan="1" rowspan="1">-14</td>
                                <td align="center" colspan="1" rowspan="1">2045</td>
                                <td align="center" colspan="1" rowspan="1">15</td>
                                <td align="center" colspan="1" rowspan="1">2038</td>
                                <td align="center" colspan="1" rowspan="1">8</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Taraba</td>
                                <td align="center" colspan="1" rowspan="1">80 (65, 98)</td>
                                <td align="center" colspan="1" rowspan="1">-9</td>
                                <td align="center" colspan="1" rowspan="1">2035</td>
                                <td align="center" colspan="1" rowspan="1">5</td>
                                <td align="center" colspan="1" rowspan="1">2031</td>
                                <td align="center" colspan="1" rowspan="1">1</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Yobe</td>
                                <td align="center" colspan="1" rowspan="1">93 (80, 109)</td>
                                <td align="center" colspan="1" rowspan="1">-10</td>
                                <td align="center" colspan="1" rowspan="1">2037</td>
                                <td align="center" colspan="1" rowspan="1">7</td>
                                <td align="center" colspan="1" rowspan="1">2033</td>
                                <td align="center" colspan="1" rowspan="1">3</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">
                                    <bold>North-West</bold>
                                </td>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Jigawa</td>
                                <td align="center" colspan="1" rowspan="1">189 (172, 206)</td>
                                <td align="center" colspan="1" rowspan="1">-16</td>
                                <td align="center" colspan="1" rowspan="1">2071</td>
                                <td align="center" colspan="1" rowspan="1">41</td>
                                <td align="center" colspan="1" rowspan="1">2041</td>
                                <td align="center" colspan="1" rowspan="1">11</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Kaduna</td>
                                <td align="center" colspan="1" rowspan="1">87 (75, 102)</td>
                                <td align="center" colspan="1" rowspan="1">-10</td>
                                <td align="center" colspan="1" rowspan="1">2050</td>
                                <td align="center" colspan="1" rowspan="1">20</td>
                                <td align="center" colspan="1" rowspan="1">2032</td>
                                <td align="center" colspan="1" rowspan="1">2</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Kano</td>
                                <td align="center" colspan="1" rowspan="1">205 (193, 217)</td>
                                <td align="center" colspan="1" rowspan="1">-16</td>
                                <td align="center" colspan="1" rowspan="1">2073</td>
                                <td align="center" colspan="1" rowspan="1">43</td>
                                <td align="center" colspan="1" rowspan="1">2042</td>
                                <td align="center" colspan="1" rowspan="1">12</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Katsina</td>
                                <td align="center" colspan="1" rowspan="1">125 (111, 139)</td>
                                <td align="center" colspan="1" rowspan="1">-12</td>
                                <td align="center" colspan="1" rowspan="1">2060</td>
                                <td align="center" colspan="1" rowspan="1">30</td>
                                <td align="center" colspan="1" rowspan="1">2036</td>
                                <td align="center" colspan="1" rowspan="1">6</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Kebbi</td>
                                <td align="center" colspan="1" rowspan="1">155 (140, 171)</td>
                                <td align="center" colspan="1" rowspan="1">-14</td>
                                <td align="center" colspan="1" rowspan="1">2066</td>
                                <td align="center" colspan="1" rowspan="1">36</td>
                                <td align="center" colspan="1" rowspan="1">2039</td>
                                <td align="center" colspan="1" rowspan="1">9</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Sokoto</td>
                                <td align="center" colspan="1" rowspan="1">134 (119, 150)</td>
                                <td align="center" colspan="1" rowspan="1">-13</td>
                                <td align="center" colspan="1" rowspan="1">2062</td>
                                <td align="center" colspan="1" rowspan="1">32</td>
                                <td align="center" colspan="1" rowspan="1">2037</td>
                                <td align="center" colspan="1" rowspan="1">7</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Zamfara</td>
                                <td align="center" colspan="1" rowspan="1">209 (193, 226)</td>
                                <td align="center" colspan="1" rowspan="1">-16</td>
                                <td align="center" colspan="1" rowspan="1">2074</td>
                                <td align="center" colspan="1" rowspan="1">44</td>
                                <td align="center" colspan="1" rowspan="1">2042</td>
                                <td align="center" colspan="1" rowspan="1">12</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">
                                    <bold>South-East</bold>
				</td>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Abia</td>
                                <td align="center" colspan="1" rowspan="1">88 (70, 111)</td>
                                <td align="center" colspan="1" rowspan="1">-10</td>
                                <td align="center" colspan="1" rowspan="1">2058</td>
                                <td align="center" colspan="1" rowspan="1">28</td>
                                <td align="center" colspan="1" rowspan="1">2032</td>
                                <td align="center" colspan="1" rowspan="1">2</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Anambra</td>
                                <td align="center" colspan="1" rowspan="1">57 (43, 76)</td>
                                <td align="center" colspan="1" rowspan="1">-6</td>
                                <td align="center" colspan="1" rowspan="1">2044</td>
                                <td align="center" colspan="1" rowspan="1">14</td>
                                <td align="center" colspan="1" rowspan="1">2027</td>
                                <td align="center" colspan="1" rowspan="1">3 years early</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Ebonyi</td>
                                <td align="center" colspan="1" rowspan="1">49 (36, 66)</td>
                                <td align="center" colspan="1" rowspan="1">-5</td>
                                <td align="center" colspan="1" rowspan="1">2039</td>
                                <td align="center" colspan="1" rowspan="1">9</td>
                                <td align="center" colspan="1" rowspan="1">2025</td>
                                <td align="center" colspan="1" rowspan="1">5 years early</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Enugu</td>
                                <td align="center" colspan="1" rowspan="1">50 (33, 64)</td>
                                <td align="center" colspan="1" rowspan="1">-5</td>
                                <td align="center" colspan="1" rowspan="1">2040</td>
                                <td align="center" colspan="1" rowspan="1">10</td>
                                <td align="center" colspan="1" rowspan="1">2025</td>
                                <td align="center" colspan="1" rowspan="1">5 years early</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Imo</td>
                                <td align="center" colspan="1" rowspan="1">89 (72, 111)</td>
                                <td align="center" colspan="1" rowspan="1">-10</td>
                                <td align="center" colspan="1" rowspan="1">2058</td>
                                <td align="center" colspan="1" rowspan="1">28</td>
                                <td align="center" colspan="1" rowspan="1">2032</td>
                                <td align="center" colspan="1" rowspan="1">2</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">
                                    <bold>South-South</bold>
                                </td>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Akwa Ibom</td>
                                <td align="center" colspan="1" rowspan="1">88 (72, 107)</td>
                                <td align="center" colspan="1" rowspan="1">-10</td>
                                <td align="center" colspan="1" rowspan="1">2032</td>
                                <td align="center" colspan="1" rowspan="1">2</td>
                                <td align="center" colspan="1" rowspan="1">2032</td>
                                <td align="center" colspan="1" rowspan="1">2</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Bayelsa</td>
                                <td align="center" colspan="1" rowspan="1">103 (87, 124)</td>
                                <td align="center" colspan="1" rowspan="1">-11</td>
                                <td align="center" colspan="1" rowspan="1">2034</td>
                                <td align="center" colspan="1" rowspan="1">4</td>
                                <td align="center" colspan="1" rowspan="1">2034</td>
                                <td align="center" colspan="1" rowspan="1">4</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Cross River</td>
                                <td align="center" colspan="1" rowspan="1">55 (42, 72)</td>
                                <td align="center" colspan="1" rowspan="1">-6</td>
                                <td align="center" colspan="1" rowspan="1">2026</td>
                                <td align="center" colspan="1" rowspan="1">4 years early</td>
                                <td align="center" colspan="1" rowspan="1">2026</td>
                                <td align="center" colspan="1" rowspan="1">4 years early</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Delta</td>
                                <td align="center" colspan="1" rowspan="1">62 (48, 80)</td>
                                <td align="center" colspan="1" rowspan="1">-7</td>
                                <td align="center" colspan="1" rowspan="1">2028</td>
                                <td align="center" colspan="1" rowspan="1">2 years early</td>
                                <td align="center" colspan="1" rowspan="1">2028</td>
                                <td align="center" colspan="1" rowspan="1">2 years early</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Edo</td>
                                <td align="center" colspan="1" rowspan="1">68 (62, 76)</td>
                                <td align="center" colspan="1" rowspan="1">-8</td>
                                <td align="center" colspan="1" rowspan="1">2029</td>
                                <td align="center" colspan="1" rowspan="1">1 year early</td>
                                <td align="center" colspan="1" rowspan="1">2029</td>
                                <td align="center" colspan="1" rowspan="1">1 year early</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Rivers</td>
                                <td align="center" colspan="1" rowspan="1">68 (52, 90)</td>
                                <td align="center" colspan="1" rowspan="1">-8</td>
                                <td align="center" colspan="1" rowspan="1">2029</td>
                                <td align="center" colspan="1" rowspan="1">1 year early</td>
                                <td align="center" colspan="1" rowspan="1">2029</td>
                                <td align="center" colspan="1" rowspan="1">1 year early</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">
                                    <bold>South-West</bold>
                                </td>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                                <td align="center" colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Ekiti</td>
                                <td align="center" colspan="1" rowspan="1">76 (57, 101)</td>
                                <td align="center" colspan="1" rowspan="1">-9</td>
                                <td align="center" colspan="1" rowspan="1">2067</td>
                                <td align="center" colspan="1" rowspan="1">37</td>
                                <td align="center" colspan="1" rowspan="1">2030</td>
                                <td align="center" colspan="1" rowspan="1">On target</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Lagos</td>
                                <td align="center" colspan="1" rowspan="1">64 (53, 77)</td>
                                <td align="center" colspan="1" rowspan="1">-7</td>
                                <td align="center" colspan="1" rowspan="1">2059</td>
                                <td align="center" colspan="1" rowspan="1">29</td>
                                <td align="center" colspan="1" rowspan="1">2028</td>
                                <td align="center" colspan="1" rowspan="1">2 years early</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Ogun</td>
                                <td align="center" colspan="1" rowspan="1">74 (57, 96)</td>
                                <td align="center" colspan="1" rowspan="1">-8</td>
                                <td align="center" colspan="1" rowspan="1">2065</td>
                                <td align="center" colspan="1" rowspan="1">35</td>
                                <td align="center" colspan="1" rowspan="1">2030</td>
                                <td align="center" colspan="1" rowspan="1">2 years early</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Ondo</td>
                                <td align="center" colspan="1" rowspan="1">80 (63, 102)</td>
                                <td align="center" colspan="1" rowspan="1">-9</td>
                                <td align="center" colspan="1" rowspan="1">2069</td>
                                <td align="center" colspan="1" rowspan="1">39</td>
                                <td align="center" colspan="1" rowspan="1">2031</td>
                                <td align="center" colspan="1" rowspan="1">1</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Osun</td>
                                <td align="center" colspan="1" rowspan="1">91 (70, 117)</td>
                                <td align="center" colspan="1" rowspan="1">-10</td>
                                <td align="center" colspan="1" rowspan="1">2074</td>
                                <td align="center" colspan="1" rowspan="1">44</td>
                                <td align="center" colspan="1" rowspan="1">2032</td>
                                <td align="center" colspan="1" rowspan="1">2</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">&#x00a0;&#x00a0;&#x00a0;&#x00a0;Oyo</td>
                                <td align="center" colspan="1" rowspan="1">81 (64, 102)</td>
                                <td align="center" colspan="1" rowspan="1">-9</td>
                                <td align="center" colspan="1" rowspan="1">2069</td>
                                <td align="center" colspan="1" rowspan="1">39</td>
                                <td align="center" colspan="1" rowspan="1">2031</td>
                                <td align="center" colspan="1" rowspan="1">1</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">
                                    <bold>National</bold>
                                </td>
                                <td align="center" colspan="1" rowspan="1">118 (115, 121)</td>
                                <td align="center" colspan="1" rowspan="1">
                                    <bold>-12</bold>
                                </td>
                                <td align="center" colspan="1" rowspan="1">
                                    <bold>2052</bold>
                                </td>
                                <td align="center" colspan="1" rowspan="1">
                                    <bold>22</bold>
                                </td>
                                <td align="center" colspan="1" rowspan="1">
                                    <bold>2036</bold>
                                </td>
                                <td align="center" colspan="1" rowspan="1">
                                    <bold>6</bold>
                                </td>
                            </tr>
                        </tbody>
                    </table>
                    <table-wrap-foot>
                        <fn>
                            <p>
				
                                <underline>Notes:</underline>
			</p>
                            <p>1. Under-five mortality rate (U5MR) was defined as the probability that a child who was born alive dies in the first five years of life, expressed per 1,000 live births. </p>
                            <p>2. Average Annual Rate of Change (AARC) was calculated using the formula: 
                                <inline-formula>
                                    <mml:math display="inline" id="M200">
                                        <mml:mrow>
                                            <mml:mi>A</mml:mi>
                                            <mml:mi>A</mml:mi>
                                            <mml:mi>R</mml:mi>
                                            <mml:mi>C</mml:mi>
                                            <mml:mo>=</mml:mo>
                                            <mml:mfrac>
                                                <mml:mrow>
                                                    <mml:mrow>
                                                        <mml:mo>(</mml:mo>
                                                        <mml:mrow>
                                                            <mml:mstyle scriptlevel="1">
                                                                <mml:mfrac bevelled="true">
                                                                    <mml:mrow>
                                                                        <mml:mi>U</mml:mi>
                                                                        <mml:mn>5</mml:mn>
                                                                        <mml:mi>M</mml:mi>
                                                                        <mml:msub>
                                                                            <mml:mi>R</mml:mi>
                                                                            <mml:mrow>
                                                                                <mml:mi>e</mml:mi>
                                                                                <mml:mi>n</mml:mi>
                                                                                <mml:mi>d</mml:mi>
                                                                            </mml:mrow>
                                                                        </mml:msub>
                                                                    </mml:mrow>
                                                                    <mml:mrow>
                                                                        <mml:mi>U</mml:mi>
                                                                        <mml:mn>5</mml:mn>
                                                                        <mml:mi>M</mml:mi>
                                                                        <mml:msub>
                                                                            <mml:mi>R</mml:mi>
                                                                            <mml:mrow>
                                                                                <mml:mi>s</mml:mi>
                                                                                <mml:mi>t</mml:mi>
                                                                                <mml:mi>a</mml:mi>
                                                                                <mml:mi>r</mml:mi>
                                                                                <mml:mi>t</mml:mi>
                                                                            </mml:mrow>
                                                                        </mml:msub>
                                                                    </mml:mrow>
                                                                </mml:mfrac>
                                                            </mml:mstyle>
                                                        </mml:mrow>
                                                        <mml:mo>)</mml:mo>
                                                    </mml:mrow>
                                                </mml:mrow>
                                                <mml:mrow>
                                                    <mml:mi>E</mml:mi>
                                                    <mml:mi>n</mml:mi>
                                                    <mml:mi>d</mml:mi>
                                                    <mml:mo>&#x2212;</mml:mo>
                                                    <mml:mi>S</mml:mi>
                                                    <mml:mi>t</mml:mi>
                                                    <mml:mi>a</mml:mi>
                                                    <mml:mi>r</mml:mi>
                                                    <mml:mi>t</mml:mi>
                                                </mml:mrow>
                                            </mml:mfrac>
                                            <mml:mo>&#x2217;</mml:mo>
                                            <mml:mn>100.</mml:mn>
                                        </mml:mrow>
                                    </mml:math>
                                </inline-formula> Positive values indicate rising under-five mortality rates while negative values indicate falling under-five mortality rates.</p>
                            <p>3. Sustainable Development Goals (SDG) target for under-five mortality rate is 25 deaths per 1000 live births by 2030.</p>
                        </fn>
                    </table-wrap-foot>
                </table-wrap>
                <p>Historical estimates of AARDs for U5MR ranged from 4.0% to 4.5% per year at the national level. At the subnational level, AARD for U5MR was highest in the South-South zone (at 8.4% per year), but showed reversals in the South-East zone with rates of increase as high as 2.5% per year (see 
                    <xref ref-type="table" rid="T3">Table 3</xref>).</p>
                <p>Our model suggests that Nigeria is not on track to meet the SDG target for U5MR (SDG 3.2.2) by 2030. At current national AARDs, it will achieve SDG 3.2.2 in 2052 (22 years behind schedule). At the subnational level, 5 out of 37 states will meet or surpass the SDG 3.2.2 target on or before 2030, while the other 32 states are not on track to achieve SDG 3.2.2 target by 2030. The years in which states will reach U5MR targets for SDG range from 2021 (9 years ahead of schedule) in Kwara state to 2074 (44 years behind schedule) in Zamfara and Osun states (see 
                    <xref ref-type="table" rid="T5">Table 5</xref> and 
                    <xref ref-type="fig" rid="f2">Figure 2B</xref>).</p>
                <p>If all states maintained an AARD in U5MR equal to the best performing in country (i.e. 8.4% decline per year), Nigeria will still not meet its U5MR target by 2030, but would do so by 2036 (six years behind schedule). In this scenario, 13 out of 37 states will meet or surpass their targets for U5MR by 2030, while the other 24 will not. The years in which states will reach U5MR targets for SDG range from 2020 (10 years early) in Kwara state to 2042 (12 years behind schedule) in Kano and Zamfara states (see 
                    <xref ref-type="table" rid="T5">Table 5</xref>).</p>
            </sec>
            <sec>
                <title>iii) Avertable neonatal and under-five deaths between 2018 and 2030</title>
                <p>We estimated the number of neonatal and under-five deaths that would occur between 2018 and 2030 under four different scenarios described in the Methods section above (sub-section on quantifying avertable deaths between 2018 and 2030). 
                    <xref ref-type="fig" rid="f3">Figure 3</xref> shows trends in mortality rates and number of annual deaths for each of the four scenarios over the period 2018 to 2030. In the &#x201c;do nothing&#x201d; scenario, in which each state maintains its 2017 NMR and U5MR throughout the period 2018 to 2030, a total of 4.3 million neonatal deaths and 12.4 million under-five deaths would occur between 2018 and 2030 (see 
                    <xref ref-type="table" rid="T6">Table 6</xref>). This number of deaths translates to an average of 330,000 neonatal deaths per year and 950,000 under-five deaths per year between 2018 and 2030. In the second scenario, the &#x201c;historical trends&#x201d; scenario, in which we applied the historical rates of decline for each zone to all states within the zone, there would be an estimated 3.5 million neonatal deaths and 9.3 million under-five deaths between 2018 and 2030. In the third scenario, the &#x201c;best in country&#x201d; scenario, in which every state would attain the AARD observed by the best performing in country, there would be an estimated 2.5 million neonatal deaths and 7.5 million under-five deaths between 2018 and 2030. In our last scenario, the &#x201c;SDG target&#x201d; scenario, in which each state will maintain from 2018&#x2013;2030 the AARD required to reach the SDG targets for NMR and U5MR by 2030, there would be an estimated 2.4 million neonatal deaths and 6.4 million under-five deaths over this time period.</p>
                <table-wrap id="T6" orientation="portrait" position="anchor">
                    <label>Table 6. </label>
                    <caption>
                        <title>Projected number of neonatal and under-five deaths between 2018 and 2030 if current mortality rates persist.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th colspan="1" rowspan="1"/>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">Total deaths
                                    <break/>(2018 to 2030)</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">Average annual deaths
                                    <break/>(2018 to 2030)</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">2018 to 2020</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">2021 to 2025</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">2025 to 2030</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">Neonatal deaths</td>
                                <td align="center" colspan="1" rowspan="1">4,332,601 </td>
                                <td align="center" colspan="1" rowspan="1">333,277 </td>
                                <td align="center" colspan="1" rowspan="1">842,948 </td>
                                <td align="center" colspan="1" rowspan="1">1,601,587 </td>
                                <td align="center" colspan="1" rowspan="1">1,888,066 </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">Under-five deaths</td>
                                <td align="center" colspan="1" rowspan="1">12,408,845 </td>
                                <td align="center" colspan="1" rowspan="1">954,527 </td>
                                <td align="center" colspan="1" rowspan="1">2,415,162 </td>
                                <td align="center" colspan="1" rowspan="1">4,587,492 </td>
                                <td align="center" colspan="1" rowspan="1">5,406,190 </td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <fig fig-type="figure" id="f3" orientation="portrait" position="float">
                    <label>Figure 3. </label>
                    <caption>
                        <title>Annual estimates of neonatal mortality rates, neonatal mortality counts, under-five mortality rates, and under-five mortality counts between 2018 and 2030.</title>
                    </caption>
                    <graphic orientation="portrait" position="float" xlink:href="https://gatesopenresearch-files.f1000.com/manuscripts/14030/46d60af9-208e-44c4-85bc-d98523c0495a_figure3.gif"/>
                </fig>
                <p>Comparing each scenario with the baseline &#x201c;do nothing&#x201d; scenario, we estimate that if states maintain historical AARDs, at least 850,000 neonatal deaths will be averted between 2018 and 2030 while 3.1 million or more under-five deaths will be averted in the same period compared to the baseline. However, if every state achieves and maintains the best AARD achieved during the MDG era, at least 1.83 million neonatal deaths and 4.9 million under-five deaths would be averted between 2018 and 2030. In the event that each state in Nigeria achieves and maintains the AARD required for it to meet its SDG targets for NMR and U5MR, we estimate that compared to the baseline scenario, at least 1.89 million neonatal deaths and 5.96 million under-five deaths will be averted between 2018 and 2030 (
                    <xref ref-type="table" rid="T7">Table 7</xref>).</p>
                <table-wrap id="T7" orientation="portrait" position="anchor">
                    <label>Table 7. </label>
                    <caption>
                        <title>Number of neonatal and under-five deaths averted between 2018 and 2030 under different scenarios.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="center" colspan="1" rowspan="1"/>
                                <th align="center" colspan="4" rowspan="1" valign="bottom">Projected total number of deaths
                                    <break/>(2018 to 2030)</th>
                                <th align="center" colspan="3" rowspan="1" valign="bottom">Projected number of deaths averted over baseline
                                    <break/>(2018 to 2030)</th>
                            </tr>
                            <tr>
                                <th align="center" colspan="1" rowspan="1"/>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">(1)</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">(2)</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">(3)</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">(4)</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">(5)</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">(6)</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">(7)</th>
                            </tr>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="bottom">Age</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">No change in
                                    <break/>mortality rate
                                    <break/>(Baseline)</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">Assuming
                                    <break/>current AARC
                                    <break/>trend</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">Best in-country
                                    <break/>AARC</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">SDG track</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">Current
                                    <break/>AARC trends
                                    <break/>(2) - (1)</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">Best in-country
                                    <break/>AARC
                                    <break/>(3) - (1)</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">AARC required for
                                    <break/>SDG
                                    <break/>(4) - (1)</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="bottom">Neonatal
                                    <break/>mortality</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">4,332,601</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">3,480,237</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">2,497,842</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">2,440,131</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">852,364</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">1,834,759</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">1,892,470</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="bottom">Under-five
                                    <break/>mortality</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">12,408,845</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">9,301,971</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">7,454,166</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">6,449,871</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">3,106,874</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">4,954,678</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">5,958,973</td>
                            </tr>
                        </tbody>
                    </table>
                    <table-wrap-foot>
                        <fn>
                            <p>
                                <underline>Notes:</underline>
                            </p>
                            <p>1. Average Annual Rate of Change (AARC) was calculated using the formula: 
                                <inline-formula>
                                    <mml:math display="inline" id="M20">
                                        <mml:mrow>
                                            <mml:mi>A</mml:mi>
                                            <mml:mi>A</mml:mi>
                                            <mml:mi>R</mml:mi>
                                            <mml:mi>C</mml:mi>
                                            <mml:mo>=</mml:mo>
                                            <mml:mfrac>
                                                <mml:mrow>
                                                    <mml:mrow>
                                                        <mml:mo>(</mml:mo>
                                                        <mml:mrow>
                                                            <mml:mstyle scriptlevel="1">
                                                                <mml:mfrac bevelled="true">
                                                                    <mml:mrow>
                                                                        <mml:mi>M</mml:mi>
                                                                        <mml:msub>
                                                                            <mml:mi>R</mml:mi>
                                                                            <mml:mrow>
                                                                                <mml:mi>e</mml:mi>
                                                                                <mml:mi>n</mml:mi>
                                                                                <mml:mi>d</mml:mi>
                                                                            </mml:mrow>
                                                                        </mml:msub>
                                                                    </mml:mrow>
                                                                    <mml:mrow>
                                                                        <mml:mi>M</mml:mi>
                                                                        <mml:msub>
                                                                            <mml:mi>R</mml:mi>
                                                                            <mml:mrow>
                                                                                <mml:mi>s</mml:mi>
                                                                                <mml:mi>t</mml:mi>
                                                                                <mml:mi>a</mml:mi>
                                                                                <mml:mi>r</mml:mi>
                                                                                <mml:mi>t</mml:mi>
                                                                            </mml:mrow>
                                                                        </mml:msub>
                                                                    </mml:mrow>
                                                                </mml:mfrac>
                                                            </mml:mstyle>
                                                        </mml:mrow>
                                                        <mml:mo>)</mml:mo>
                                                    </mml:mrow>
                                                </mml:mrow>
                                                <mml:mrow>
                                                    <mml:mi>E</mml:mi>
                                                    <mml:mi>n</mml:mi>
                                                    <mml:mi>d</mml:mi>
                                                    <mml:mo>&#x2212;</mml:mo>
                                                    <mml:mi>S</mml:mi>
                                                    <mml:mi>t</mml:mi>
                                                    <mml:mi>a</mml:mi>
                                                    <mml:mi>r</mml:mi>
                                                    <mml:mi>t</mml:mi>
                                                </mml:mrow>
                                            </mml:mfrac>
                                            <mml:mo>&#x2217;</mml:mo>
                                            <mml:mn>100.</mml:mn>
                                        </mml:mrow>
                                    </mml:math>
                                </inline-formula> Positive values indicate rising neonatal mortality rates while negative values indicate falling neonatal mortality rates.</p>
                            <p>2. The &#x201c;No Change&#x201d; scenario assumes that the mortality rate observed in 2018 for each sub-national entity would be maintained at the same level between 2018 and 2030 (i.e. AARC = 0).</p>
                            <p>3. The &#x201c;Current AARC&#x201d; scenario assumes that mortality rates for each sub-national entity continue to change between 2018 and 2030, at the AARC observed in the most recent five years for which data is available.</p>
                            <p>4. The &#x201c;Best In-Country&#x201d; scenario assumes that all subnational entities achieves AARCs between 2018 and 2030, that are similar to that achieved by the best performing sub-national entity in the most recent five years for which data is available.</p>
                            <p>5. The &#x201c;AARC for SDG&#x201d; scenario assumes that between 2018 and 2030, each sub-national entity will achieve the AARC it requires in order to achieve the Sustainable Development Goals (SDG) target for that mortality rate.</p>
                        </fn>
                    </table-wrap-foot>
                </table-wrap>
                <p>Our models suggest that even if Nigeria achieves its SDG targets for NMR of 12 per 1,000 live births by 2030, there would still be at least 139,000 neonatal deaths per year if the NMR remains at the SDG target rate with no further improvement. In the same vein, if Nigeria achieves its SDG targets for U5MR of 25 per 1,000 live births, we project that on average, there would still be at least 308,000 under-five deaths per year if the U5MR remains at the SDG target rate with no further improvement.</p>
            </sec>
            <sec>
                <title>iv) State performance and concentration of the burden of mortality</title>
                <p>We ranked states based on their most recent levels of NMR and U5MR, as well as their contributions to the annual number of neonatal and under-5 deaths. 
                    <xref ref-type="table" rid="T8">Table 8</xref> lists the states in the top and bottom performance quintiles measured by mortality rates, while 
                    <xref ref-type="table" rid="T9">Table 9</xref> lists the states that account for the largest portion of neonatal and under-five mortality based on 2018 estimates.</p>
                <table-wrap id="T8" orientation="portrait" position="anchor">
                    <label>Table 8. </label>
                    <caption>
                        <title>Best and worst performing states for neonatal and under-five mortality rates.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="center" colspan="6" rowspan="1">Best performing states
                                    <break/>(Top 20%, by 2017 mortality rate estimates)</th>
                            </tr>
                            <tr>
                                <th align="left" colspan="1" rowspan="1">State</th>
                                <th align="center" colspan="1" rowspan="1">Neonatal mortality rate</th>
                                <th align="center" colspan="1" rowspan="1">Rank</th>
                                <th align="left" colspan="1" rowspan="1">State</th>
                                <th align="center" colspan="1" rowspan="1">Under-five mortality rate</th>
                                <th align="center" colspan="1" rowspan="1">Rank</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">Kwara</td>
                                <td align="center" colspan="1" rowspan="1">12</td>
                                <td align="center" colspan="1" rowspan="1">1</td>
                                <td align="left" colspan="1" rowspan="1">Kwara</td>
                                <td align="center" colspan="1" rowspan="1">32</td>
                                <td align="center" colspan="1" rowspan="1">1</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">Taraba</td>
                                <td align="center" colspan="1" rowspan="1">17</td>
                                <td align="center" colspan="1" rowspan="1">2</td>
                                <td align="left" colspan="1" rowspan="1">Enugu</td>
                                <td align="center" colspan="1" rowspan="1">46</td>
                                <td align="center" colspan="1" rowspan="1">2</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">Cross River</td>
                                <td align="center" colspan="1" rowspan="1">18</td>
                                <td align="center" colspan="1" rowspan="1">3</td>
                                <td align="left" colspan="1" rowspan="1">Ebonyi</td>
                                <td align="center" colspan="1" rowspan="1">49</td>
                                <td align="center" colspan="1" rowspan="1">3</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">Adamawa</td>
                                <td align="center" colspan="1" rowspan="1">20</td>
                                <td align="center" colspan="1" rowspan="1">4</td>
                                <td align="left" colspan="1" rowspan="1">Cross River</td>
                                <td align="center" colspan="1" rowspan="1">55</td>
                                <td align="center" colspan="1" rowspan="1">4</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">Anambra</td>
                                <td align="center" colspan="1" rowspan="1">21</td>
                                <td align="center" colspan="1" rowspan="1">5</td>
                                <td align="left" colspan="1" rowspan="1">Anambra</td>
                                <td align="center" colspan="1" rowspan="1">57</td>
                                <td align="center" colspan="1" rowspan="1">5</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">Ebonyi</td>
                                <td align="center" colspan="1" rowspan="1">22</td>
                                <td align="center" colspan="1" rowspan="1">6</td>
                                <td align="left" colspan="1" rowspan="1">Delta</td>
                                <td align="center" colspan="1" rowspan="1">62</td>
                                <td align="center" colspan="1" rowspan="1">6</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">FCT Abuja</td>
                                <td align="center" colspan="1" rowspan="1">23</td>
                                <td align="center" colspan="1" rowspan="1">7</td>
                                <td align="left" colspan="1" rowspan="1">Lagos</td>
                                <td align="center" colspan="1" rowspan="1">64</td>
                                <td align="center" colspan="1" rowspan="1">7</td>
                            </tr>
                            <tr>
                                <th align="center" colspan="6" rowspan="1">Worst performing states
                                    <break/>(Bottom 20%, by 2017 mortality rate estimates)</th>
                            </tr>
                            <tr>
                                <th align="left" colspan="1" rowspan="1">State</th>
                                <th align="center" colspan="1" rowspan="1">Neonatal mortality rate</th>
                                <th align="center" colspan="1" rowspan="1">Rank</th>
                                <th align="left" colspan="1" rowspan="1">State</th>
                                <th align="center" colspan="1" rowspan="1">Under-five mortality rate</th>
                                <th align="center" colspan="1" rowspan="1">Rank</th>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">Bauchi</td>
                                <td align="center" colspan="1" rowspan="1">41</td>
                                <td align="center" colspan="1" rowspan="1">31</td>
                                <td align="left" colspan="1" rowspan="1">Sokoto</td>
                                <td align="center" colspan="1" rowspan="1">134</td>
                                <td align="center" colspan="1" rowspan="1">31</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">Kebbi</td>
                                <td align="center" colspan="1" rowspan="1">44</td>
                                <td align="center" colspan="1" rowspan="1">32</td>
                                <td align="left" colspan="1" rowspan="1">Gombe</td>
                                <td align="center" colspan="1" rowspan="1">151</td>
                                <td align="center" colspan="1" rowspan="1">32</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">Nasarawa</td>
                                <td align="center" colspan="1" rowspan="1">47</td>
                                <td align="center" colspan="1" rowspan="1">33</td>
                                <td align="left" colspan="1" rowspan="1">Bauchi</td>
                                <td align="center" colspan="1" rowspan="1">154</td>
                                <td align="center" colspan="1" rowspan="1">33</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">Osun</td>
                                <td align="center" colspan="1" rowspan="1">49</td>
                                <td align="center" colspan="1" rowspan="1">34</td>
                                <td align="left" colspan="1" rowspan="1">Kebbi</td>
                                <td align="center" colspan="1" rowspan="1">155</td>
                                <td align="center" colspan="1" rowspan="1">34</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">Niger</td>
                                <td align="center" colspan="1" rowspan="1">50</td>
                                <td align="center" colspan="1" rowspan="1">35</td>
                                <td align="left" colspan="1" rowspan="1">Jigawa</td>
                                <td align="center" colspan="1" rowspan="1">189</td>
                                <td align="center" colspan="1" rowspan="1">35</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">Zamfara</td>
                                <td align="center" colspan="1" rowspan="1">52</td>
                                <td align="center" colspan="1" rowspan="1">36</td>
                                <td align="left" colspan="1" rowspan="1">Kano</td>
                                <td align="center" colspan="1" rowspan="1">205</td>
                                <td align="center" colspan="1" rowspan="1">36</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1">Kano</td>
                                <td align="center" colspan="1" rowspan="1">65</td>
                                <td align="center" colspan="1" rowspan="1">37</td>
                                <td align="left" colspan="1" rowspan="1">Zamfara</td>
                                <td align="center" colspan="1" rowspan="1">209</td>
                                <td align="center" colspan="1" rowspan="1">37</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <table-wrap id="T9" orientation="portrait" position="anchor">
                    <label>Table 9. </label>
                    <caption>
                        <title>States with the highest neonatal and under-five mortality burden.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="center" colspan="6" rowspan="1" valign="bottom">States with the highest burdens of neonatal and under-five mortality</th>
                            </tr>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="bottom">State</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">Estimated number of
                                    <break/>neonatal deaths in 2018</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">% of national
                                    <break/>neonatal deaths</th>
                                <th align="left" colspan="1" rowspan="1" valign="bottom">State</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">Estimated number of
                                    <break/>under-five deaths in 2018</th>
                                <th align="center" colspan="1" rowspan="1" valign="bottom">% of national under-five
                                    <break/>deaths</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="bottom">Kano</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">34,200</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">13%</td>
                                <td align="left" colspan="1" rowspan="1" valign="bottom">Kano</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">107,800</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">14%</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="bottom">Lagos</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">17,800</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">7%</td>
                                <td align="left" colspan="1" rowspan="1" valign="bottom">Jigawa</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">43,900</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">6%</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="bottom">Oyo</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">12,100</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">4%</td>
                                <td align="left" colspan="1" rowspan="1" valign="bottom">Bauchi</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">40,500</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">5%</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="bottom">Katsina</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">11,600</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">4%</td>
                                <td align="left" colspan="1" rowspan="1" valign="bottom">Katsina</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">39,000</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">5%</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="bottom">Niger</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">11,300</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">4%</td>
                                <td align="left" colspan="1" rowspan="1" valign="bottom">Zamfara</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">37,900</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">5%</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="bottom">Bauchi</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">10,700</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">4%</td>
                                <td align="left" colspan="1" rowspan="1" valign="bottom">Lagos</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">31,300</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">4%</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="bottom">Kaduna</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">9,600</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">4%</td>
                                <td align="left" colspan="1" rowspan="1" valign="bottom">Niger</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">28,200</td>
                                <td align="center" colspan="1" rowspan="1" valign="bottom">4%</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <p>States performing in the top quintile for NMR include Kwara, Taraba, Cross River, Adamawa, Anambra, Ebonyi, and the Federal Capital Territory, with NMRs between 12 and 23 per 1,000 live births in 2017. States performing in the bottom quintile for NMR include Bauchi, Kebbi, Nasarawa, Osun, Niger, Zamfara, and Kano, with NMRs between 41 and 65 per 1,000 live births in 2017.</p>
                <p>For U5MR, the states performing in the top quintile include Kwara, Enugu, Ebonyi, Cross River, Anambra, Delta, and Lagos, with U5MRs between 32 and 64 per 1,000 live births in 2017. By contrast, states performing in the bottom quintile for U5MR include Sokoto, Gombe, Bauchi, Kebbi, Jigawa, Kano, and Zamfara, with U5MR between 134 and 209 per 1,000 live births in 2017.</p>
                <p>Our model shows that Kano state accounts for 13% of projected national neonatal mortality in 2018 with an estimated 34,000 neonatal deaths, and 14% of projected national under-five mortality in 2018 with an estimated 108,000 under-five deaths. In sum, only a small number of states account for about 40% of total neonatal and under-five deaths in 2018. They include Kano, Lagos, Oyo, Katsina, Niger, Bauchi, and Kaduna states for neonatal mortality, and Kano, Jigawa, Bauchi, Katsina, Zamfara, Lagos, and Niger for under-five mortality (see 
                    <xref ref-type="table" rid="T9">Table 9</xref> for details)</p>
            </sec>
        </sec>
        <sec sec-type="discussion">
            <title>Discussion</title>
            <sec>
                <title>Statement of principal findings</title>
                <p>Based on recent survey data and analysis of historical trends, we modeled future trends in state-level neonatal and under-five mortality in Nigeria between 2018 and 2030. Our findings show that if historical trends continue, Nigeria as a country, and multiple states within the country, are unlikely to meet the SDG targets for neonatal and under-five mortality by 2030. While some states have already attained or will attain the SDG targets several years before 2030, others are projected to attain the SDG targets as late as 2088 (58 years behind schedule).</p>
                <p>We also show that if current mortality rates remain unchanged, up to 4.3 million neonatal deaths and 12.5 million under-five deaths are likely to occur in Nigeria between 2018 and 2030. However, if each state attains the required annual rate of decline needed to achieve the SDG targets for neonatal and under-five mortality, 1.9 million neonatal deaths and 5 million under-five deaths can be averted between 2018 and 2030.</p>
                <p>Another important finding from this study is that if Nigeria only meets the SDG targets and does not surpass them&#x2014;in other words, if it only achieves a U5MR of 25 deaths per 1,000 live births and an NMR of 12 deaths per 1,000 live births by 2030&#x2014;the country would still have a high burden of avertable mortality. In a scenario in which it reaches these two SDG targets, at least 139,000 neonatal deaths and 308,000 under-five deaths would still occur every year in Nigeria. This annual number of deaths translates to more than 800 under-five deaths per day.</p>
            </sec>
            <sec>
                <title>Comparison with other estimates</title>
                <p>Our estimates are consistent with the 2016 estimates of the NMR and U5MR in Nigeria from the Global Burden of Disease (GBD) study. The 2016 GBD estimated an NMR for Nigeria of 35.7 per 1,000 live births (95% CI: 28.8-43.5) for NMR and a U5MR of 108.7 per 1,000 live births (95% CI: 93.0- 126.2)
                    <sup>
                        <xref ref-type="bibr" rid="ref-6">6</xref>
                    </sup>.</p>
                <p>In addition, our projections are consistent with projections from three other groups: (a) the UN Inter-agency Group for Child Mortality Estimation (UN-IGCME)
                    <sup>
                        <xref ref-type="bibr" rid="ref-11">11</xref>
                    </sup>, (b) the GBD 2016 SDG collaborators
                    <sup>
                        <xref ref-type="bibr" rid="ref-12">12</xref>
                    </sup>, and (c) McArthur and colleagues
                    <sup>
                        <xref ref-type="bibr" rid="ref-13">13</xref>
                    </sup>. All three studies found that if current trends persist, Nigeria will not reach its SDG targets for child mortality by 2030.</p>
                <p>However, our study goes a step further to provide state-level estimates and assessment of states&#x2019; performance. Our estimates are also consistent with those of Liu and colleagues, who showed that by 2030, Nigeria would account for up to 7% the estimated 4.4 million annual child deaths in 2030
                    <sup>
                        <xref ref-type="bibr" rid="ref-14">14</xref>
                    </sup>.</p>
            </sec>
            <sec>
                <title>Strengths and weaknesses of the study</title>
                <p>Our study contributes to the current literature in important ways. To the best of our knowledge, this is the first study to make subnational projections of neonatal and under-five mortality in Nigeria. Sub-national modeling is important because primary health care is mostly managed at the state and local government levels in Nigeria, not at the federal government. Our finding of a large disparity in mortality rates between states shows that they have performed very differently in adopting and scaling up child survival policies, thus we hope that our state level analysis will be helpful to policymakers. The lack of state-level estimates and projections make it difficult for policy makers at the state level to track their performance or make informed decisions about the future effects of certain health policies.</p>
                <p>Our study uses the recently released MICS 2016&#x2013;2017 household survey data, which has a number of advantages. This is the most recent household survey conducted in Nigeria, it has both national and state-level estimates for neonatal and under-five mortality, and it is the only one conducted in the post-2015 SDG era. Therefore, our analysis provides a good baseline for policy making.</p>
                <p>Another strength of our study is that we adopted reasonable assumptions of rates of change. While we could have chosen to model scenarios with the rates of change of the best performing countries outside Nigeria, we decided to keep our analysis grounded in historical evidence. We therefore restricted our analysis of scenarios to rates of decline that have been achieved within Nigeria, and compared them to what will need to be achieved for the SDG targets to be met.</p>
                <p>One important limitation of our study is that although we show differences in state-level performance for both neonatal and under-five mortality, we do not analyze the reasons for these differences. So, our study has not shown 
                    <italic toggle="yes">why</italic> some states perform better than others or 
                    <italic toggle="yes">which policies</italic> might have improved their performance. This is an important subject for future research.</p>
            </sec>
            <sec>
                <title>Implications for policy makers</title>
                <p>The wide variation in performance in neonatal and under-five mortality seen across states in this study creates an opportunity for states to learn from each other. While a state like Kwara has already met the SDG target for NMR, other states like Zamfara and Kano will only meet their SDG targets for NMR around 2079 (a 49-year delay) and 2088 (a 58-year delay) respectively, if their current rates of decline are maintained. For under-five mortality, while Kwara state is projected to reach its U5MR targets for SDG3 around 2021 (9 years ahead of schedule), others like Zamfara and Osun states are projected to reach their U5MR targets for SDG3 by 2074 (44 years behind schedule).</p>
                <p>Highlighting these differences is only a first step. Opportunities are needed for greater dialogue among policymakers within the different states. These dialogues could take the form of study visits to states performing in the top quintile for neonatal mortality (Kwara, Taraba, Cross River, Adamawa, Anambra, Ebonyi, and the Federal Capital Territory) and under-five mortality (Kwara, Enugu, Ebonyi, Cross River, Anambra, Delta, and Lagos states). They could also take the form of collaborative learning networks, or joint programming. Fostering these dialogues will encourage partnerships, stimulate homegrown innovation, and create an environment where evidence-based learning and decision making becomes the norm. One model for this kind of shared learning is the 
                    <ext-link ext-link-type="uri" xlink:href="http://www.jointlearningnetwork.org/">Joint Learning Network for Universal Health Coverage</ext-link>.</p>
                <p>Another important policy implication of this study is that it highlights the importance of not just tracking mortality rates, but also tracking rates of change. While current mortality rates create a snapshot of performance at the time of the survey, it is impossible for policy makers to project how much progress is possible or feasible without paying attention to rates of change. For example, while neonatal mortality rates in the south-west region of the country were better than other regions between the period 2003 and 2013, they ended the period with NMR worse than at the beginning because of the rates of change they experienced. By contrast, the north-west and north-east zones have the highest neonatal mortality rates by recent estimates, but over time they have shown some progress in the form of a downward trend.</p>
                <p>The importance of rates of decline are further seen in the modeling of different scenarios in our study. For example, if every state within the country achieves an AARD equal to the best performers (8% per year for NMR, and 8.4% per year for U5MR), a total of 1.8 million neonatal or 4.9 million under-five deaths would be averted between 2018 and 2030. If, on the other hand, each state achieves the AARD required to meet its SDG3 target (between 0% and 13% for NMR, and between 2% and 16% per year for U5MR), a total of 1.9 million neonatal deaths or 5.9 million under-five deaths could be averted between 2018 and 2030. However, achieving such high rates of decline will require sustained efforts on the part of policy makers. For comparison, in the period between 2006 and 2016, Rwanda, with all its investments in health reform, recorded an average rate of decline in under-five mortality of 9.2% per year
                    <sup>
                        <xref ref-type="bibr" rid="ref-13">13</xref>
                    </sup>. Our study found that the best rates of decline achieved in Nigeria were 8% per year for NMR and 8.4% per year for U5MR over a 10-year period from 2003 to 2013. Furthermore, long-run estimates of average rates of decline in U5MR for Nigeria between 1990 and 2016 (a 26-year period) were between 2.7% and 3.3% per year
                    <sup>
                        <xref ref-type="bibr" rid="ref-6">6</xref>,
                        <xref ref-type="bibr" rid="ref-7">7</xref>
                    </sup>. Therefore, a policy maker seeking to achieve an AARD of up to 16% in Nigeria should be prepared to make the required investments and sustain these investments over the long-run. This would require innovation, resources, persistence, and political will.</p>
                <p>Finally, although our study did not analyze the reasons for variation across states, there is sufficient evidence in the literature on interventions that can reduce neonatal and under-five mortality in low- and middle-income countries. From recent estimates, the main causes of under-five mortality in Nigeria include malaria, diarrheal diseases, neonatal encephalopathy, lower respiratory tract infections, and neonatal preterm births
                    <sup>
                        <xref ref-type="bibr" rid="ref-5">5</xref>,
                        <xref ref-type="bibr" rid="ref-15">15</xref>
                    </sup>. These are all conditions for which there are simple, low-cost, lifesaving interventions
                    <sup>
                        <xref ref-type="bibr" rid="ref-16">16</xref>&#x2013;
                        <xref ref-type="bibr" rid="ref-18">18</xref>
                    </sup>. Reliable platforms also exist to deliver these interventions
                    <sup>
                        <xref ref-type="bibr" rid="ref-18">18</xref>&#x2013;
                        <xref ref-type="bibr" rid="ref-20">20</xref>
                    </sup> and are captured in the Global Strategy for Women&#x2019;s, Children&#x2019;s and Adolescent Health (2016&#x2013;2030)
                    <sup>
                        <xref ref-type="bibr" rid="ref-21">21</xref>
                    </sup>.</p>
                <p>Even though there are wide variations in mortality rates exist across the country, there is evidence that the main causes of child mortality do not vary significantly across the country. Uthman and colleagues conducted an exploratory spatial analysis of under-five mortality in Nigeria using data from the 2008 Nigeria Demographic and Health Survey, and concluded that the &#x201c;vast majority of states (73%)&#x201d; do not show evidence of special-cause variation in under-five mortality
                    <sup>
                        <xref ref-type="bibr" rid="ref-22">22</xref>
                    </sup>. Therefore, there is potential for remarkable progress by addressing the common causes.</p>
            </sec>
        </sec>
        <sec sec-type="conclusions">
            <title>Conclusion</title>
            <p>Although estimates from our study and several others suggest that Nigeria will not meet its SDG targets for NMR and U5MR at current rates of decline, we show that there is wide variation at the state level with some states already at SDG3 targets and others projected to experience delays of up to 58 years. These variations create opportunities for low-performing states to learn from high-performing states. As Nigeria moves towards achieving its child survival targets, it will be critical for policymakers at the state-level to track their performance on both SDG targets for NMR (SDG 3.2.1) and U5MR (SDG 3.2.2), measure their performance against the policies they introduce, and continuously assess what is possible by comparing their performance with high performing states. Doing this will help avert millions of child deaths in Nigeria between 2018 and 2030.</p>
        </sec>
        <sec>
            <title>Data availability</title>
            <sec>
                <title>Source data</title>
                <p>All datasets used in this study (Nigeria 2016-07 Survey) are publicly available at 
                    <ext-link ext-link-type="uri" xlink:href="https://dhsprogram.com/">https://dhsprogram.com/</ext-link> and 
                    <ext-link ext-link-type="uri" xlink:href="http://mics.unicef.org/surveys">http://mics.unicef.org/surveys</ext-link>. Interested readers can access the data by filling out an online form describing the intended use of the data. Once approved, data can be downloaded from the respective sites. The online form is accessible following clicking to download the file via the MICS site.</p>
            </sec>
            <sec>
                <title>Extended data</title>
                <p>Open Science Framework: Supplementary data: How many child deaths can be averted in Nigeria? Assessing state-level prospects of achieving 2030 sustainable development goals for neonatal and under-five mortality. 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.17605/OSF.IO/8QMKE">https://doi.org/10.17605/OSF.IO/8QMKE</ext-link>
                    <sup>
                        <xref ref-type="bibr" rid="ref-10">10</xref>
                    </sup>
                </p>
                <p>This project contains the following extended data:</p>
                <list list-type="bullet">
                    <list-item>
                        <p>Supplement for -- State_level_trends_in_maternal_and_child_mortality_in_Nigeria_25MAR2019_Final.pdf (Expanded methods and results)</p>
                    </list-item>
                </list>
                <p>Data are available under the terms of the 
                    <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">Creative Commons Zero &#x201c;No rights reserved&#x201d; data waiver</ext-link> (CC0 1.0 Public domain dedication).</p>
            </sec>
        </sec>
    </body>
    <back>
        <ack>
            <title>Acknowledgements</title>
            <p>Thanks to Kaci Kennedy McDade and Ipchita Bharali for editorial and administrative support.</p>
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    <sub-article article-type="reviewer-report" id="report27674">
        <front-stub>
            <article-id pub-id-type="doi">10.21956/gatesopenres.14030.r27674</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Cha</surname>
                        <given-names>Seungman</given-names>
                    </name>
                    <xref ref-type="aff" rid="r27674a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0003-1264-3313</uri>
                </contrib>
                <aff id="r27674a1">
                    <label>1</label>London School of Hygiene &amp; Tropical Medicine, London, UK</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>30</day>
                <month>9</month>
                <year>2019</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2019 Cha S</copyright-statement>
                <copyright-year>2019</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport27674" related-article-type="peer-reviewed-article" xlink:href="10.12688/gatesopenres.12928.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>
                <bold>Baseline scenario</bold>
            </p>
            <p> I think that the baseline scenario should be the mortality rate based on historical trends rather than an unchanging MR. I would suggest the authors to re-describe discussion parts particularly in relation to the key findings on the basis of comparison between the scenario 2 and scenario 4.</p>
            <p> 
                <bold>Novelty of the estimation methods</bold>
            </p>
            <p> Measuring progress towards SDG targets for neonatal and under-five mortality rates based on different set of scenarios such as historical trends, worst and best case, and SDG target scenario has been applied in several studies. Although some of these studies were done at the global level, these studies should be referenced since the methodology particularly with regards to the four types of scenario is not novel. (For instance. You 
                <italic>et al.,&#x00a0;</italic>2015
                <sup>
                    <xref ref-type="bibr" rid="rep-ref-27674-1">1</xref>
                </sup>; Alkema 
                <italic>et al.,&#x00a0;</italic>2016
                <sup>
                    <xref ref-type="bibr" rid="rep-ref-27674-2">2</xref>
                </sup>)</p>
            <p> </p>
            <p> In addition, the study done by Nick Golding
                <sup>
                    <xref ref-type="bibr" rid="rep-ref-27674-3">3</xref>
                </sup> should be stated in the background, particularly regarding its limitation and needs for another study in Nigeria.&#x00a0;</p>
            <p> The fact that there exists enormous inequality in U5MR, NMR and its progress by province/state has been emphasized in a number of papers and UN reports. I hope that the authors could add at least one paragraph about the possible explanations for the remarkable progress in certain provinces of Nigeria, which will make the paper more attractive to the potential readers working in other countries with similar context.</p>
            <p> 
                <bold>References</bold>
            </p>
            <p> Some of the references should be updated or added. For instance, Global Burden of Disease 2018 publications.</p>
            <p> Can the authors add a legend for X-axis for Figure 2?</p>
            <p> Overall, this paper contains important findings and is thus worth to be published.</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Partly</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Partly</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Partly</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Yes</p>
            <p>Reviewer Expertise:</p>
            <p>Health inequality in maternal and child health</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
        <back>
            <ref-list>
                <title>References</title>
                <ref id="rep-ref-27674-1">
                    <label>1</label>
                    <mixed-citation publication-type="journal">
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                        <article-title>Global, regional, and national levels and trends in under-5 mortality between 1990 and 2015, with scenario-based projections to 2030: a systematic analysis by the UN Inter-agency Group for Child Mortality Estimation</article-title>.
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    </sub-article>
    <sub-article article-type="reviewer-report" id="report27197">
        <front-stub>
            <article-id pub-id-type="doi">10.21956/gatesopenres.14030.r27197</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Burstein</surname>
                        <given-names>Roy</given-names>
                    </name>
                    <xref ref-type="aff" rid="r27197a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0001-8991-4762</uri>
                </contrib>
                <aff id="r27197a1">
                    <label>1</label>Institute for Disease Modeling&#x00a0;(IDM), Bellevue, WA, USA</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>18</day>
                <month>6</month>
                <year>2019</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2019 Burstein R</copyright-statement>
                <copyright-year>2019</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport27197" related-article-type="peer-reviewed-article" xlink:href="10.12688/gatesopenres.12928.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>The authors address the important issue of subnational variation in under-5 mortality. They produce subnational estimates of neonatal and under-5 mortality for all states in Nigeria and develop four projection scenarios and estimate death counts to compare how future burden will play out. They conclude that, based on past trends, it is unlikely for Nigeria as a whole, or even for most states therein, to achieve the SDG 3.2 by 2030. And, even if all states achieve unprecedented declines in mortality rate needed to achieve the SDGs, an estimated 6.5 million under-5 deaths would be projected to occur between 2018 and 2030. This paper would be of interest for researchers involved in child mortality estimation and for those working in Nigeria to reduce child mortality.</p>
            <p> </p>
            <p> The aim of the paper is clear, but I have several comments about the choice of data, the description of methods, presentation of results, and the discussion. I hope the authors will find my thoughts useful as they continue to improve on this work.</p>
            <p> </p>
            <p> 
                <underline>Major comments:</underline> 
                <list list-type="order">
                    <list-item>
                        <p>It is unclear in your methods description which data sources were used for which estimates. You have produced mortality rates for five-year periods (2003-2008, and 2008-2013) and cite the NDHSs of 2003, 2008, and 2013. I would assume you used the 2013 survey for 2008-2013 and the 2008 survey for 2003-2008, but please clarify, because it could also be possible to use the 2013 survey to inform the 2003-2008 period. And in any case, why even mention the 2003 survey if (as I assume, but correct me if I am wrong) you aren&#x2019;t using it?</p>
                    </list-item>
                    <list-item>
                        <p>I am unclear on how mortality rates were assigned for a specific year. You describe a multiple decrement life-table approach for a pooled 10-year estimate from the 2016/2017 MICS. Is this the estimate you call 2017 in tables 4 and 5? Or was this some sort of projection made using the equation from row 3 of table 1?</p>
                    </list-item>
                    <list-item>
                        <p>As for that equation (row 3 of table 1), if you are assuming exponential change, shouldn&#x2019;t you use the following: MR_t = MR_{t-n}*exp(aarc*n), the equation in the last row of table 1. I am not sure when each equation is implemented in your analysis.</p>
                    </list-item>
                    <list-item>
                        <p>It&#x2019;s unclear to me what years were actually used for AARC calculation. Were the estimates from pooled 2003-2008 and 2008-2013 estimates considered 5 years apart from one another? These omitted details have left me a bit confused on exactly how your projected estimates for scenario 2 come about.</p>
                    </list-item>
                    <list-item>
                        <p>Instead of pooling 10 years of data, why did you not use a synthetic cohort approach to directly estimate annual mortality rates from the surveys?</p>
                    </list-item>
                    <list-item>
                        <p>If I understand your analysis correctly, you are using cohort deaths in year y, instead of period deaths, is this true? Are deaths attributed to a particular year actually deaths for the birth cohort from that year?</p>
                    </list-item>
                    <list-item>
                        <p>The 2013 NDHS was designed to allow for representative estimates at the state level. Instead of using geopolitical zone AARCs, why don&#x2019;t you use estimates from the NDHS to make state level AARCs? Even if you don&#x2019;t use it for your final model, it would be a very useful sensitivity test to better understand the impact of your simplifying assumption of zone-level AARCs.</p>
                    </list-item>
                    <list-item>
                        <p>I was surprised to see that you used a national crude birth rate for projection of births (Supplemental appendix, equation 2). You justify this in a footnote saying that while it will underestimate fertility in the north, it will overestimate it in the south, thus averaging out to make reliable national level estimates. I don&#x2019;t think this is a justifiable assumption to be making in a paper where your claimed strength is to be making subnational projections. According to the 2013 NDHS, total fertility rates vary over two-fold between states (from around 4 to around 8). This variation is unignorable and will certainly impact your estimates of deaths projected at the state level quite significantly. It should be possible to use the surveys to get subnational fertility to use here.</p>
                    </list-item>
                    <list-item>
                        <p>I take some issue with calling an unchanging MR &#x201c;business as usual&#x201d;. More realistically, it can be argued that &#x2018;business as usual&#x2019; is scenario two (MR declines based on historic trends), and that a flat trend would be exceptionally bad at this point. Beyond just a rhetorical issue, I think this colours your discussion too. It&#x2019;s really an unrealistic scenario, so then to highlight that the gap between this scenario and the meet-SDG (scenario 4) case is an additional 5 million deaths is needlessly provocative. I think a much fairer &#x201c;business as usual&#x201d; comparison would be between scenarios 2 and 4. Still a staggering difference of about 3 million deaths between 2018 and 2030.</p>
                    </list-item>
                    <list-item>
                        <p>This paper would be greatly improved if you quantified uncertainty in your estimates of mortality rate and subsequently AARC. As they are derived from population samples, your estimates of mortality are not as precise as is led on in the paper, where you only use mean estimates. For example, without an analysis of the uncertainty, it is unclear if the increases in AARC you observe in the South-East are real. Since you have access to microdata, this should be doable.</p>
                    </list-item>
                    <list-item>
                        <p>I was disappointed by the lack of contextual discussion about health in Nigeria. The discussion section was somewhat technical without going into details about the health policies that could be shaping the results presented in the paper. For example, for what reasons is Kwara state possibly doing so well? What policies or interventions have been implemented in the states with the fastest declines? There was a lot of room given to the somewhat obvious conclusion that states could learn from each other&#x2019;s successes, but the lack of broader context and specific examples seems like a missed opportunity.</p>
                    </list-item>
                    <list-item>
                        <p>I hate to be one of 
                            <italic>those</italic> reviewers who interject about their own paper, but the lack of mention of Golding 
                            <italic>et al.</italic> (2017
                            <sup>
                                <xref ref-type="bibr" rid="rep-ref-27197-1">1</xref>
                            </sup>) felt like an oversight. In that analysis, we produced estimates of state level neonatal and under-5 mortality in 46 African countries including in Nigeria. We also estimated the annualized rate of change needed to achieve the SDGs at the subnational level. This felt missing in your &#x2018;Comparison with other estimates&#x2019; section. We also found that Nigeria was unlikely to meet the SDGs, but I think it would be very interesting to make direct comparisons between MRs/AROCs from that work and yours. It is also untrue as you state in discussion that yours is the first paper to make subnational projections of NMR and U5MR in Nigeria.</p>
                    </list-item>
                </list> 
                <underline>And then I have some more minor comments:</underline> 
                <list list-type="order">
                    <list-item>
                        <p>In your methods supplement you refer to infant mortality rate (IMR) throughout, but your paper focuses on neonatal mortality. This is a strange disconnect between the two and the supplement should be updated to align with main body of the manuscript.</p>
                    </list-item>
                    <list-item>
                        <p>In the intro, you say that the 2016/2017 MICS &#x201c;for the first time allows state-level estimation of NMR and U5MR&#x201d;. I believe that the 2013 NDHS was designed to be representative at the state level.</p>
                    </list-item>
                    <list-item>
                        <p>The last part of the last paragraph in the discussion section about special-causes and common causes was confusing. I wasn&#x2019;t sure what this meant.</p>
                    </list-item>
                    <list-item>
                        <p>I think figure 2 would be more effective as a map where each state is coloured by the year. The lack of meaning of the X-axis as it currently stands is kind of strange.</p>
                    </list-item>
                    <list-item>
                        <p>Table 1, it looks like the rows are mis-numbered as the third row starts back at 1.</p>
                    </list-item>
                    <list-item>
                        <p>Table 6, should the last column read &#x201c;2026 to 2030&#x201d;?</p>
                    </list-item>
                </list>
            </p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Partly</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Partly</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Partly</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Yes</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Reviewer Expertise:</p>
            <p>Child mortality estimation, geospatial modelling.</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
        <back>
            <ref-list>
                <title>References</title>
                <ref id="rep-ref-27197-1">
                    <label>1</label>
                    <mixed-citation publication-type="journal">
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                        <article-title>Mapping under-5 and neonatal mortality in Africa, 2000&#x2013;15: a baseline analysis for the Sustainable Development Goals</article-title>.
                        <source>
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                        </source>.<year>2017</year>;<volume>390</volume>(<issue>10108</issue>) :
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                    </mixed-citation>
                </ref>
            </ref-list>
        </back>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report27275">
        <front-stub>
            <article-id pub-id-type="doi">10.21956/gatesopenres.14030.r27275</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Salinas-Miranda</surname>
                        <given-names>Abraham A.</given-names>
                    </name>
                    <xref ref-type="aff" rid="r27275a1">1</xref>
                    <xref ref-type="aff" rid="r27275a2">2</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0001-7749-6110</uri>
                </contrib>
                <aff id="r27275a1">
                    <label>1</label>Centro de Investigaciones y Estudios de la Salud, Universidad Nacional Autonoma de Nicaragua, Managua, Nicaragua</aff>
                <aff id="r27275a2">
                    <label>2</label>Center of Excellence in Maternal and Child Health, Department of Community and Family Health, College of Public Health, University of South Florida, Tampa, FL, USA</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>18</day>
                <month>6</month>
                <year>2019</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2019 Salinas-Miranda AA</copyright-statement>
                <copyright-year>2019</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport27275" related-article-type="peer-reviewed-article" xlink:href="10.12688/gatesopenres.12928.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>I was asked to review the article entitled "How many child deaths can be averted in Nigeria? Assessing state-level prospects of achieving 2030 sustainable development goals for neonatal and under-five mortality". This article presents projections of neonatal and under-five child mortality&#x00a0;in Nigeria under the scenarios of current trends and at best in-country trends. This type of study permits decision-makers to allocate resources for timely action that can accelerate progress toward the attainment of the SDGs. Therefore, it's an important topic and of interest to the readership of the Gates Open Research Journal. The objectives, data sources, methods, and results are consistent and sound. Some minor changes are needed to improve the value of this manuscript. The recommendation is to accept, upon revisions. A summary of my assessment is below:</p>
            <p> &#x00a0; 
                <list list-type="bullet">
                    <list-item>
                        <p>Abstract: The authors need to indicate the study design in the abstract. There is no mentioning of the overall study design.</p>
                        <p> </p>
                    </list-item>
                    <list-item>
                        <p>Introduction: The authors did a good job justifying their study and stating the purpose of the study. One aspect needs revision. In the last paragraph of the introduction, the authors mention the unique opportunity of new MICS, but they did not mention the availability of the DHS. Together, these permit the estimation of the scenarios presented. As it is currently written, it could be interpreted that the study was based on MICS only.&#x00a0;</p>
                        <p> </p>
                    </list-item>
                    <list-item>
                        <p>Methods: The authors presented an adequate account of the selection of data sources, variable definition, calculation of rates, and time horizons. However, they overlooked to indicate the type of study design. It was conducted in three phases, but historical trends were used for the projections. This means that is very likely that the design is either a&#x00a0;time series (ecological study) or another form of ecological study that permits trends analysis. To this reviewer, it seems to be an ecological design&#x00a0;(given that unit of analysis is not at the individual but at the aggregated level of geopolitical zones), which uses&#x00a0;econometric methods (forecasting).&#x00a0;</p>
                        <p> </p>
                        <p> In addition, more details are needed about the forecasting technique that was used with STATA as there are several that can be used to estimate the predicted values (e.g. autoregressive (AR) models&#x00a0;or autoregressive distributed lag (ADL) models?, jointpoint regression based on permutation tests, ordinary least squares, etc.). This is necessary to permit replicability for other researchers. As it is right now, the arithmetic calculations for the rates are clear, but the statistical explanation is insufficient. The information in the extended data was useful, but it did not contain the information on the statistical program (do.file) used in STATA.&#x00a0;</p>
                        <p> </p>
                    </list-item>
                    <list-item>
                        <p>Results: These are well-described. Kudos to the authors for using AARD and AARC, as those are more robust measures for trends.&#x00a0;</p>
                        <p> </p>
                    </list-item>
                    <list-item>
                        <p>Conclusion: The authors support their conclusions adequately based on the results for each of the scenarios presented. The recommendations are reasonable.</p>
                        <p> </p>
                        <p> However, the limitations can be expanded to address the issues with using DHS data (cross-sectional, self-reported), not only MICS. They mentioned MICS in the limitations, but not the DHS. Also, they should note the assumptions of forecasting (e.g. the longer the forecast, the less reliable). Trend extrapolation methods that use historical data, such as&#x00a0;in this study, use mathematical techniques to extrapolate to the future. The assumption is that the forces responsible for changes in the past, will continue to exert influence in the future. Although this is often a valid assumption when forecasting short term horizons, it may not be for medium and long term forecasts (e.g. year 2043). The further out we attempt to forecast, the less certain we become of the forecast. Hence, the authors need to discuss this limitation for the long term predictions they made under the scenarios proposed.&#x00a0;The instability of the sociopolitical environment in Nigeria may need&#x00a0;to be discussed as a&#x00a0;key factor in determining whether trend extrapolation will be an appropriate forecasting model (projections) in the coming years. For that reason, they should recommend updating the forecasting (projection) in a few years in the future.&#x00a0;</p>
                        <p> </p>
                        <p> Nevertheless, despite limitations, the study has value for decision-making as it relies on the most recent and most reliable data sources available for the country of Nigeria and its geopolitical zones. &#x00a0;</p>
                        <p> </p>
                    </list-item>
                    <list-item>
                        <p>Other: Citations for each of the DHS reports are needed.&#x00a0;</p>
                    </list-item>
                </list>
            </p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Yes</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Yes</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Partly</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Yes</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Reviewer Expertise:</p>
            <p>Research areas: maternal and child health, family violence. Approaches: epidemiological methods using extant datasets, including meta-analysis, trends analysis, multiple linear regression (OLS), logistic regression, path analysis (structural equation models), and others.</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.</p>
        </body>
    </sub-article>
</article>
